Tyrphostin 47 is a protein tyrosine kinase inhibitor particularly potent against epidermal growth factor receptor (EGFR) kinase activity. Tyrphostin 47 has been observed to inhibit GTPase activity of transducin and the homologous insulin receptor kinase. It has also been found to also inhibit hyperactive motility of hamster spermatozoa. Tyrphostin 47 interferes with the proximal EGFR signaling pathway, causes G1-S transition arrest, and induces apoptosis in the human MCF-7 breast cancer cell line. In vero cell cultures, this product induced cell death and p38 MAPK phosphorylation.

A potent inhibitor of EGFR kinase activity

>97%

Store at -20° C

Solid

AG 213

~1.5 g/cm³ (Predicted)

175.04° C (Predicted)

~474.5° C at 760 mmHg (Predicted)

n20/D 1.78

EGFR: IC₅₀ = 2.4 µM; PDGFR: IC₅₀ = 3.5 µM; p210bcr-abl: IC₅₀ = 5.9 µM; insulin receptor: IC₅₀ = 640 µM; protein kinase C: IC₅₀ = 60 µM

Soluble in ethanol (20 mg/ml), DMSO (20 mg/ml), 1:1 DMSO:PBS (~0.5 mg/ml,pH 7.2), DMF (~15 mg/ml), and acetone.

MFCD00133902

5485187

6508337