ODN 2006——人TLR9激动剂

发表于2024年9月26日由上海金畔生物科技有限公司

ODN 2006——人TLR9激动剂

TLR9识别特定的未甲基化的CpG-ODN序列，其只存在于微生物DNA而不存在与哺乳动物的DNA。InvivoGen可提供三种类型的刺激型ODNs：A性、B型和C型，也可提供对照ODNs和抑制型ODNs。

CpG ODNs是一种合成的寡核苷酸，在CpG motifs序列处含有非甲基化的CpG二核苷酸，这些CpG motifs在细菌DNA出现的频率为哺乳动物DNA的20倍。CpG ODNs可被toll样受体9识别，诱导很强的免疫刺激效应。

ODN 2006属于B型CpG ODNs，为人TLR9的配体。 B型CpG ODNs包含一个完整的硫代磷酸酯主体和一个或多个CpG二核苷酸。可强有效的活化B细胞但是弱刺激IFN-α的分泌。

ODN 2006 Vaccigrade™适用于临床前研究，在严格的无菌条件下制备，确保无菌，并且内毒素含量非常低。

产品名称	产品描述	规格	货号
ODN 2006 (ODN 7909)	TLR9 Agonist – Stimulatory CpG ODN, Class B, Human specific	200ug	tlrl-2006
		1mg	tlrl-2006-1
		5mg	tlrl-2006-5
ODN 2006 Vaccigrade™	TLR9 agonist – CpG ODN, class B (human) Th1 response	1mg	vac-2006-1
ODN 2006 control (ODN 2137)	ODN 2137 : Negative control for ODN 2006	200ug	tlrl-2006c
		1mg	tlrl-2006c-1
		5mg	tlrl-2006c-5
ODN 2006 Biotin	TLR9 Agonist – Biotin-labelled CpG ODN 2006, Class B, Human specific	50ug	tlrl-2006b
ODN 2006 FITC	TLR9 Agonist – FITC-labelled CpG ODN 2006, Class B, Human specific	50ug	tlrl-2006f
ODN 2006-G5	TLR9 Agonist – Stimulatory CpG ODN, Class B, Human specific	200ug	tlrl-2006g5
ODN 2006-G5 control	Negative control for ODN 2006-G5	1mg	tlrl-2006g5-1
		5mg	tlrl-2006g5-5
		200ug	tlrl-2006g5c

TLR9配体–Invivogen产品列表

发表于2024年6月17日由上海金畔生物科技有限公司

TLR9配体–Invivogen产品列表

法国Invivogen公司提供TLR9配体相关产品，包含各种抑制剂、激动剂和化合物库，专注于信号通路和疾病研究领域，致力于为生命科学研究提供高质量的试剂类产品和服务。如您需要以下TLR9配体的相关产品，或是Invivogen公司的其他产品，请联系代理商上海金畔生物。

TLR9配体产品列表

产品编号	产品名称	规格
tlrl-1585c-1	ODN 1585 control	1 mg
tlrl-1668c-1	ODN 1668 control	1 mg
tlrl-1668f	ODN 1668 FITC	50 µg
tlrl-2006g5c	ODN 2006-G5 control	200 µg
tlrl-2336c	ODN 2336 control	200 µg
tlrl-1585	ODN 1585	200 µg
tlrl-1585-1	ODN 1585	1 mg
tlrl-1585-5	ODN 1585	5 mg
tlrl-bw007	ODN BW007	200 µg
tlrl-1668	ODN 1668	200 µg
tlrl-1668-1	ODN 1668	1 mg
tlrl-1668-5	ODN 1668	5 mg
tlrl-1668c-5	ODN 1668 control	5 mg
tlrl-1826	ODN 1826	200 µg
tlrl-1826-1	ODN 1826	1 mg
tlrl-1826-5	ODN 1826	5 mg
tlrl-1826b	ODN 1826 Biotin	2 x 50 µg
tlrl-1826c-1	ODN 1826 control (ODN 2138)	1 mg
tlrl-1826c-5	ODN 1826 control (ODN 2138)	5 mg
tlrl-1826f	ODN 1826 FITC	50 µg
tlrl-2006	ODN 2006 (ODN 7909)	200 µg
tlrl-2006-1	ODN 2006 (ODN 7909)	1 mg
tlrl-2006-5	ODN 2006 (ODN 7909)	5 mg
tlrl-2006b	ODN 2006 Biotin	2 x 50 µg
tlrl-2006c	ODN 2006 control (ODN 2137)	200 µg
tlrl-2006c-1	ODN 2006 control (ODN 2137)	1 mg
tlrl-2006c-5	ODN 2006 control (ODN 2137)	5 mg
tlrl-2006f	ODN 2006 FITC	50 µg
tlrl-2006g5	ODN 2006-G5	200 µg
tlrl-2006g5-1	ODN 2006-G5	1 mg
tlrl-2006g5-5	ODN 2006-G5	5 mg
tlrl-2007-1	ODN 2007	1 mg
tlrl-2007-5	ODN 2007	5 mg
tlrl-2088	ODN 2088	200 µg
tlrl-2088-1	ODN 2088	1 mg
tlrl-2088-5	ODN 2088	5 mg
tlrl-m362c-1	ODN M362 control	1 mg
tlrl-2088c-1	ODN 2088 control	1 mg
tlrl-2216	ODN 2216	200 µg
tlrl-2216-1	ODN 2216	1 mg
tlrl-2216-5	ODN 2216	5 mg
tlrl-2216b	ODN 2216 Biotin	2 x 50 µg
tlrl-2216f	ODN 2216 FITC	50 µg
tlrl-2243	ODN 2243 (ODN 2216 Control)	200 µg
tlrl-2243-1	ODN 2243 (ODN 2216 Control)	1 mg
tlrl-2243-5	ODN 2243 (ODN 2216 Control)	5 mg
tlrl-2336	ODN 2336	200 µg
tlrl-2336-1	ODN 2336	1 mg
tlrl-2336-5	ODN 2336	5 mg
tlrl-2395	ODN 2395	200 µg
tlrl-2395-1	ODN 2395	1 mg
tlrl-2395-5	ODN 2395	5 mg
tlrl-2395c	ODN 2395 control	200 µg
tlrl-2395c-1	ODN 2395 control	1 mg
tlrl-2395c-5	ODN 2395 control	5 mg
tlrl-2395f	ODN 2395 FITC	50 µg
tlrl-4084	ODN 4084-F	200 µg
tlrl-bw006	ODN BW006 (ODN 684)	200 µg
tlrl-dsl01	ODN D-SL01	200 µg
tlrl-dsl03	ODN D-SL03	200 µg
tlrl-inh18	ODN INH-18	200 µg
tlrl-m362	ODN M362	200 µg
tlrl-m362-1	ODN M362	1 mg
tlrl-m362-5	ODN M362	5 mg
tlrl-1585c	ODN 1585 control	200 µg
tlrl-1585c-5	ODN 1585 control	5 mg
tlrl-1668c	ODN 1668 control	200 µg
tlrl-1826c	ODN 1826 control (ODN 2138)	200 µg
tlrl-2007	ODN 2007	200 µg
tlrl-2007c	ODN 2007 control	200 µg
tlrl-2007c-1	ODN 2007 control	1 mg
tlrl-2007c-5	ODN 2007 control	5 mg
tlrl-2088c	ODN 2088 control	200 µg
tlrl-2088c-5	ODN 2088 control	5 mg
tlrl-m362c	ODN M362 control	200 µg
tlrl-m362c-5	ODN M362 control	5 mg
tlrl-ssec	E. coli ssDNA / LyoVec™	200 µg
tlrl-ttag151	ODN TTAGGG (A151)	200 µg
tlrl-ttag151-1	ODN TTAGGG (A151)	1 mg
tlrl-ttagc	ODN TTAGGG control	200 µg
tlrl-ttagc-1	ODN TTAGGG control	1 mg

更多详情请咨询Invivogen代理商-上海金畔生物

TLR13 激动剂及相关产品

发表于2024年6月11日由上海金畔生物科技有限公司

TLR13 激动剂及相关产品

TLR13是在小鼠中发现的一个胞内受体。目前关于它的配体和信号通路仍知之甚少，但23S核糖体RNA(rRNA)已被证明是它的配体之一。TLR13诱导的细胞因子释是透过依赖MyD-88和UNC93B这两个分子来激活AP-1和INF-α/β等转录因子入核。TLR13也可通过活化IRF7来诱导IFN-γ的产生。人类中不存在TLR13受体，可能是通过其它类似的病原受体来发现病原菌的入侵。

TLR13 激动剂相关产品：

PRODUCT	ORIGIN/DESCRIPTION	GRADE*	WORKING CONCENTRATION	QTY	CATALOG CODE
TLR13 Agonists
ORN Sa19	S. aureus 23S rRNA-derived oligoribonucleotide	TLR2 -/ TLR4 –	0.02 – 2 µg/ml	200 µg	tlrl-orn19
ORN Sa19 Control	Control oligoribonucleotide for ORN Sa19	TLR2 -/ TLR4 –	0.02 – 2 µg/ml	200 µg	tlrl-orn19c

更多详情请咨询Invivogen代理商-上海金畔生物

TLR7/8 激动剂及相关产品

发表于2024年6月11日由上海金畔生物科技有限公司

TLR7/8 激动剂及相关产品

TLR7和TLR8都是与病毒感染引起的免疫反应相关的胞内受体。它们识别富含GU的短单链RNA，以及咪唑喹啉和核苷类似物等人工合成的小分子。TLR7/TLR8的信号通路依赖于MyD-88的活化、AP-1和IFN-α/β等转录因子入核，以及IRF7的磷酸化。IRF7磷酸化诱导ISRE的表达和I型干扰素基因的产生，而AP-1和IFN-α/β的激活导致细胞因子的释放。

TLR7/8 激动剂相关产品：

PRODUCT	ORIGIN/DESCRIPTION	GRADE*	WORKING CONCENTRATION	QTY	CATALOG CODE
TLR7 Agonists
CL264	Adenine analog	TLR2 – /TLR4 –	50 ng – 10 µg/ml	500 µg 5 mg	tlrl-c264e tlrl-c264e-5
CL307	Hydroxyadenine spermine compound	TLR2 – /TLR4 –	5 ng – 1 µg/ml	500 µg	tlrl-c307
CL347 – AdiFectin™	Hydroxyadenine spermine compound	TLR2 – /TLR4 –	300 ng – 3 µg/ml	500 µg	tlrl-c347
CL401	PAM2C-conjugated hydroxyadenine compound	TLR2 + /TLR4 –	1 ng – 10 µg/ml	500 µg	tlrl-c401
CL401 VacciGrade™	Preclinical grade CL401	VacciGrade™	20 – 50 µg/mouse	1 mg	vac-c401-5
CL413 – Adilipoline™	PAM2CK4-conjugated hydroxyadenine compound	TLR2 + /TLR4 –	50 pg – 10 µg/ml	500 µg	tlrl-c413

TLR7 Agonists
CL413 VacciGrade™	Preclinical grade CL413	VacciGrade™	20 – 50 µg/mouse	5 mg	vac-c413-5
CL531	PAM2CK4-conjugated hydroxyadenine compound	TLR2 +/ TLR4 –	5 pg – 10 µg/ml	500 µg	tlrl-c531
CL572	Monoacyl-ethyl-cystein hydroxyadenine compound	TLR2 +/ TLR4 –	0.5 ng – 1 µg/ml	500 µg	tlrl-c572
Gardiquimod™	Imidazoquinoline compound	TLR2 -/ TLR4 –	0.1 – 3 µg/ml	500 µg 5 mg	tlrl-gdqs tlrl-gdq-5
Imiquimod (R837)	Imidazoquinoline compound	TLR2 -/ TLR4 –	1 – 5 µg/ml	500 µg 5 mg	tlrl-imqs tlrl-imq
Imiquimod VacciGrade™	Preclinical grade Imiquimod	TLR2 -/ TLR4 –	10 – 100 µg/mouse	5 mg	vac-imq
Loxoribine	Guanosine analog	TLR2 -/ TLR4 –	1 mM (300 µg/ml)	50 mg	tlrl-lox
TLR8 Agonists
ORN06/LyoVec™	ssRNA with 6 UUGU repeats / LyoVec™	TLR2 -/ TLR4 –	0.25 – 5 µg/ml	4 x 25 µg	tlrl-orn6
ssPolyU Naked	RNA homopolymer	TLR2 -/ TLR4 –	1 – 10 µg/ml	10 mg 10 x 10 mg	tlrl-sspu tlrl-sspu-100
ssPolyU/LyoVec™	RNA homopolymer / LyoVec™	TLR2 -/ TLR4 –	1 – 10 µg/ml	4 x 25 µg	tlrl-lpu
ssRNA40/LyoVec™	HIV-1 LTR-derived ssRNA / LyoVec™	TLR2 -/ TLR4 –	0.25 – 5 µg/ml	4 x 25 µg	tlrl-lrna40
ssRNA41/LyoVec™	ssRNA40 control / LyoVec™	TLR2 -/ TLR4 –	0.25 – 5 µg/ml	4 x 25 µg	tlrl-lrna41
TL8-506	Benzoazepine analog	TLR2 -/ TLR4 –	10 – 100 ng/ml	500 µg	tlrl-tl8506
TLR7/8 Agonists
CL075	Thiazoquinoline compound	TLR2 -/ TLR4 –	100 ng – 5 µg/ml	500 µg 5 mg	tlrl-c75 tlrl-c75-5
CL097	Imidazoquinoline compound	TLR2 -/ TLR4 –	50 ng – 5 µg/ml	500 µg 5 mg	tlrl-c97 tlrl-c97-5
Poly(dT)	Thymidine homopolymer ODN (17 mer)	TLR2 -/ TLR4 –	10 µM	100 nmol	tlrl-pt17
R848 (resiquimod)	Imidazoquinoline compound	TLR2 -/ TLR4 –	10 ng – 10 µg/ml	500 µg 5 mg	tlrl-r848 tlrl-r848-5
R848 VacciGrade™	Preclinical grade R848	VacciGrade™	10 – 100 µg/mouse	5 mg	vac-r848

更多详情请咨询Invivogen代理商-上海金畔生物

TLR5激动剂及相关产品

发表于2024年6月11日由上海金畔生物科技有限公司

TLR5激动剂及相关产品

细胞表面受体TLR5可识别鞭毛蛋白，后者是革兰氏阳性菌和革兰氏阴性菌表面鞭毛丝的主要成份。TLR5活化后通过MyD88信号通路促进一些炎症因子的释放。TLR5通过形成同源二聚体来激活炎症信号通路，这显示它可能是唯一参与鞭毛蛋白识别的TLR分子。

TLR5激动剂产品如下：

PRODUCT	ORIGIN/DESCRIPTION	GRADE*	WORKING CONCENTRATION	QTY	CATALOG CODE
TLR5 Agonists
FLA-BS	Standard flagellin from B. subtilis – 10% pure	TLR2 + /TLR4 +	10 ng – 10 µg/ml	100 µg	tlrl-bsfla
FLA-BS Ultrapure	Ultrapure flagellin from B. subtilis – >95% pure	TLR2 – /TLR4 –	1 ng – 1 µg/ml	50 µg	tlrl-pbsfla
FLA-PA Ultrapure	Ultrapure flagellin from P. aeruginosa – >95% pure	TLR2 – /TLR4 –	1 ng – 1 µg/ml	50 µg	tlrl-pafla
FLA-ST	Standard flagellin from S. typhimurium – 10% pure	TLR2 + /TLR4 +	10 ng – 10 µg/ml	100 µg	tlrl-stfla
FLA-ST Ultrapure	Ultrapure flagellin from S. typhimurium – >95% pure	TLR2 – /TLR4 –	10 – 100 ng/ml	10 µg 50 µg	tlrl-epstfla tlrl-epstfla-5
RecFLA-ST	Recombinant flagellin from S. typhimurium	TLR2 – /TLR4 –	10 – 100 ng/ml	50 µg 10 µg	tlrl-flic-50 tlrl-flic-10
Flagellin Flic VacciGrade™	Preclinical grade RecFLA-ST	VacciGrade™	1 – 10 µg/mouse	50 µg	vac-fla
TLR5 Antagonist
hTLR5-Fc	Soluble ectodomain of TLR5	TLR2 – /TLR4 –	10 ng- 1 µg/ml	50 µg	fc-htlr5

更多详情请咨询Invivogen代理商-上海金畔生物

TL2-C29，TLR2信号抑制剂新品上线

发表于2024年6月10日由上海金畔生物科技有限公司

TL2-C29，TLR2信号抑制剂新品上线

法国InvivoGen最新推出人TLR2/1 & TLR2/6, 小鼠TLR2/1 信号抑制剂TL2-C29，为TLR2信号研究的科研人员提供最新工具。

TL2-C29 是一种Toll样受体2 (TLR2)的小分子抑制剂 [1]，TLR2在检测来自细菌、真菌、寄生虫和病毒的多种病原相关分子模式（PAMPs）中起着非常重要的作用 [2]。TLR1和TLR6的共受体(co-receptors)对TLR2 信号和配体的特异性有关键影响。细胞表面的TLR2/TLR1和TLR2/TLR6异二聚体可分别结合三酰化和二酰化脂蛋白 [3,4]。TLR2信号是由配体诱导的TLR2异二聚体和衔接蛋白（adapter proteins）的基本细胞质TIR（Toll/IL-1受体）结构域的二聚化启动。随后的信号级联导致促炎症反应。

TL2-C29抑制TLR2信号作用机理

产品信息

名称：TL2-C29

规格：5mg

货号：inh-c29

别名: C29; TLR2-IN-C29; 3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-benzoic acid

CAS号: 363600-92-4

分子式: C₁₆H₁₅NO₄

分子量: 285.3 g/mol

溶解度: 50 mM (14.3 mg/ml) in DMSO

工作浓度: 25 – 200 µM for cell culture assays.

质控:

· Purity ≥ 95% (NMR)

· Inhibition of human TLR2/1 and TLR2/6 signaling has been confirmed using cellular assays

· The absence of bacterial contamination (e.g. lipoproteins and endotoxins) has been confirmed using HEK-Blue™ TLR2 and HEKBlue™ TLR4 cells.

主要特点:

–人TLR2/1和TLR2/6信号的高效抑制剂

–小鼠TLR2/1信号的高效抑制剂

–无明显细胞毒性

–在细胞试验上验证可抑制NF-κB/AP-1信号

–每个批次纯度均大于≥ 95%，并经过功能性测试

InvivoGen实验室数据支持

相关产品推荐

产品名称	描述
Pam3CSK4	TLR2/TLR1 Agonist – Synthetic triacylated lipopeptide
Pam2CSK4	TLR2/TLR6 Agonist – Synthetic diacylated lipopeptide
FSL-1	TLR2/TLR6 Agonist – Synthetic diacylated lipoprotein
HKLM	TLR2 Agonist – Heat Killed Listeria monocytogenes
HKPA	TLR2 Agonist – Heat Killed – Pseudomonas aeruginosa
HEK-Blue™ hTLR2	Human TLR2 / NF-κB / SEAP reporter HEK293 cells
QUANTI-Blue™	Alkaline phosphatase detection medium
HEK-Blue™ hTLR2-TLR1	Human TLR2+TLR1 / NF-κB / SEAP reporter HEK293 cells
HEK-Blue™ hTLR2-TLR6	Human TLR2+TLR6 / NF-κB / SEAP reporter HEK293 cells
HEK-Blue™ hTLR2 KO-TLR1/6	Human TLR2 (KO-TLR1/6) / NF-κB / SEAP reporter HEK293 cells

参考文献

1. Mistry, P. et al., 2015. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. PNAS. 112(17):5455-5460.
2. Oliveira-Nascimento L. et al., 2012. The role of TLR2 in infection and Immunity. Front Immunol. 3(79): doi:10.3389/fimmu.2012.00079.
3. Takeuchi O. et al., 2001. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol. 13: 933-940.
4. Takeuchi O. et al., 2002. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol. 169: 10-14

更多详情请咨询Invivogen代理商-上海金畔生物

TLR4 激动剂及相关产品介绍

发表于2024年6月9日由上海金畔生物科技有限公司

TLR4 激动剂及相关产品介绍

TLR4是革兰氏阴性菌脂多糖(LPS)和毒性成份lipid A的受体。TLR4与LPS的应答，除了受体本身，也需要另外3种不同的胞外蛋白:LBP(LPS结合蛋白)、CD14和MD-2(髓样分化蛋白2)才能发挥作用。TLR4介导的信号通路有两条:一条是MyD88依赖的，另一条是MyD88非依赖的。MyD88依赖的信号通路导致AP-1和NF-kB等转录因子入核，促进一些炎症因子的释放;MyD88非依赖的信号通路可激活IRF3和另外一个接头分子TRAM(TRIF相关的接头蛋白)，IRF3活化后可使细胞产生IFN-®️，上调一些干扰素依赖基因的表达。

TLR4激动剂相关产品：

PRODUCT	ORIGIN/DESCRIPTION	GRADE*	WORKING CONCENTRATION	QTY	CATALOG CODE
TLR4 Agonists
CRX-527 NEW	Synthetic Lipid A analog	TLR2 – /TLR4 +	100 pg/ml – 10 ng/ml	1 mg	tlrl-crx527
LPS-B5	Standard lipopolysaccharide from E. coli 055:B5	TLR2 + /TLR4 +	100 pg – 1 µg/ml	5 mg	tlrl-b5lps
LPS-B5 Ultrapure	Ultrapure lipopolysaccharide from E. coli 055:B5	TLR2 – /TLR4 +	100 pg – 1 µg/ml	5 mg	tlrl-pb5lps
LPS-EB	Standard lipopolysaccharide from E. coli 0111:B4	TLR2 + /TLR4 +	10 ng – 10 µg/ml	5 mg	tlrl-eblps
LPS-EB Biotin	Biotinylated ultrapure LPS from E. coli 0111:B4	TLR2 + /TLR4 +	10 ng – 10 µg/ml	500 µg	tlrl-3blps
LPS-EB Ultrapure	Ultrapure lipopolysaccharide from E. coli 0111:B4	TLR2 – /TLR4 +	10 ng – 10 µg/ml	5×106 EU	tlrl-3pelps
LPS-EB VacciGrade™	Preclinical grade ultrapure LPS from E. coli 0111:B4	VacciGrade™	0.1 – 25 µg/mouse	5×106 EU	vac-3pelps
LPS-EK	Standard lipopolysaccharide from E. coli K12	TLR2 + /TLR4 +	1 ng – 10 µg/ml	5 mg	tlrl-eklps
LPS-EK Ultrapure	Ultrapure lipopolysaccharide from E. coli K12	TLR2 – /TLR4 +	1 ng – 10 µg/ml	1 mg	tlrl-peklps
LPS-PG	Standard lipopolysaccharide from P. gingivalis	TLR2 + /TLR4 +	100 ng – 10 µg/ml	1 mg	tlrl-pglps
LPS-PG Ultrapure	Ultrapure lipopolysaccharide from P. gingivalis	TLR2 – /TLR4 +	100 ng – 10 µg/ml	1 mg	tlrl-ppglps
LPS-SM Ultrapure	Ultrapure lipopolysaccharide from S. minnesota	TLR2 – /TLR4 +	10 ng – 10 µg/ml	5 mg	tlrl-smlps
MPLA-SM	Monophosphoryl lipid A from S. minnesota	TLR2 – /TLR4 +	10 ng – 1 µg/ml	1 mg	tlrl-mpla
MPLA-SM VacciGrade™	Preclinical grade detoxified MPLA	VacciGrade™	2 – 20 µg/mouse	1 mg	vac-mpla
MPLA Synthetic	Synthetic monophosphoryl lipid A	TLR2 – /TLR4 +	300 pg – 100 ng/ml	1 mg	tlrl-mpls
MPLA Synthetic VacciGrade™	Preclinical grade synthetic MPLA	VacciGrade™	2 – 20 µg/mouse	1 mg	vac-mpls
TLR4 Antagonist
LPS-RS	Lipopolysaccharide from Rhodobacter sphaeroides	TLR2 + /TLR4 –	10 ng – 10 µg/ml	5 mg	tlrl-rslps
LPS-RS Ultrapure	Ultrapure lipopolysaccharide from R. sphaeroides	TLR2 – /TLR4 –	10 ng – 10 µg/ml	1 mg	tlrl-prslps

更多详情请咨询Invivogen代理商-上海金畔生物

TLR3 激动剂（CD283）及相关产品介绍

发表于2024年6月9日由上海金畔生物科技有限公司

TLR3 激动剂（CD283）及相关产品介绍

TLR3(又名CD283)是一个胞内受体，可识别与病毒感染相关的双链RNA(dsRNA)分子模式。其中一个TLR3的配体，Poly(I:C)，是人工合成的dsRNA类似物。TLR3信号通路不依赖于MyD88，而是通过接头蛋白TRIF(包含TIR结构域的接头蛋白，可诱导IFN-β产生)发挥作用。IRF3(干扰素调节因子3)被磷酸化后导致IFN-β(β干扰素)产生，进一步活化ISRE(干扰素激活反应元件)。另外，TLR3信号通路的激活也可导致AP-1和NF-kB等转录因子入核，促进一些炎症因子的释放。

TLR3激动剂相关产品：

PRODUCT	ORIGIN/DESCRIPTION	GRADE*	WORKING CONCENTRATION	QTY	CATALOG CODE
TLR LIGANDS
TLR3 Agonists
Poly(A:U)	Polyadenylic-polyuridylic acid	TLR2 -/ TLR4 –	300 ng- 100 µg/ml	10 mg	tlrl-pau
Poly(I:C) (HMW)	Polyinosine-polycytidylic acid High molecular weight (1.5-8 kb)	TLR2 -/ TLR4 –	30 ng – 10 µg/ml	10 mg 50 mg	tlrl-pic tlrl-pic-5
Poly(I:C) (HMW) Biotin	Biotinylated poly(I:C) (HMW)	TLR2 -/ TLR4 –	30 ng – 10 µg/ml	10 µg	tlrl-picb
Poly(I:C) (HMW) Fluorescein	Fluorescein-labeled poly(I:C) (HMW)	TLR2 -/ TLR4 –	10 ng – 10 µg/ml	10 µg	tlrl-picf
Poly(I:C) (HMW) Rhodamine	Rhodamine-labeled poly(I:C) (HMW)	TLR2 -/ TLR4 –	10 ng – 10 µg/ml	10 µg	tlrl-picr

PRR Ligands

PRODUCT	ORIGIN/DESCRIPTION	GRADE*	WORKING CONCENTRATION	QTY	CATALOG CODE
TLR3 Agonists
Poly(I:C) (HMW) VacciGrade™	Preclinical grade poly(I:C) (HMW)	VacciGrade™	10 µg – 100 µg/mouse	10 mg	vac-pic
Poly(I:C) (LMW)	Polyinosine-polycytidylic acid Low molecular weight (0.2-1 kb)	TLR2 – /TLR4 –	30 ng – 10 µg/ml	25 mg 250 mg	tlrl-picw tlrl-picw-250
Poly(I:C) (LMW) Rhodamine	Rhodamine-labeled poly(I:C) (LMW)	TLR2 – /TLR4 –	100 ng – 10 µg/ml	10 µg	tlrl-piwr

更多详情请咨询Invivogen代理商-上海金畔生物

TLR2激动剂(又名CD282)及相关产品介绍

发表于2024年6月9日由上海金畔生物科技有限公司

TLR2激动剂(又名CD282)及相关产品介绍

TLR2(又名CD282)是一个可以识别多种微生物表面分子的细胞膜表面受体。它识别的分子可来源于革兰氏阳性菌、革兰氏阴性菌、支原体和酵母等许多微生物种属。

TLR2识别的具体成份包括来源于革兰氏阳性菌的肽聚糖、脂膜酸、脂蛋白，来源于分枝杆菌的脂阿拉伯甘露聚糖，来源于酵母细胞壁的酵母聚糖等。

TLR2识别的配体种类在TLR家族中是最多的，因为TLR2可以和其它TLR家族成员形成异源二聚体来发挥功能。

TLR2可以和TLR6形成异源二聚体识别双酰化脂蛋白，而TLR1/TLR2异源二聚体则与三酰化脂蛋白发生相互作用。

另外，CD14共受体的存在可增强TLR2的病原识别能力。TLR2信号通路的激活依赖于MyD88分子(骨髓来源的第一应激蛋白88)，进而招募接头分子TIRAP(TIR相关蛋白)，导致AP-1和NF-kB等转录因子入核来促进一些炎症因子的释放。

TLR2激动剂相关产品：

PRODUCT	ORIGIN/DESCRIPTION	GRADE*	WORKING CONCENTRATION	QTY	CATALOG CODE
TLR LIGANDS
TLR2 Agonists
CL401	PAM2C-conjugated hydroxyadenine compound	TLR2 +/ TLR4 –	1 ng – 10 µg/ml	500 µg	tlrl-c401
CL401 VacciGrade™	Preclinical grade CL401	VacciGrade™	20 – 50 µg/mouse	5 mg	vac-c401-5
CL413 – Adilipoline™	PAM2CK4-conjugated hydroxyadenine compound	TLR2 +/ TLR4 –	50 pg – 10 µg/ml	500 µg	tlrl-c413
CL413 VacciGrade™	Preclinical grade CL413	VacciGrade™	20 – 50 µg/mouse	5 mg	vac-c413-5
CL419	Pam2C-spermine compound	TLR2 +/ TLR4 –	1 ng – 100 µg/ml	500 µg	tlrl-c419
CL429	Pam2C-conjugated murabutide	TLR2 +/ TLR4 –	1 ng – 10 µg/ml	5 mg	tlrl-c429
CL429 VacciGrade™	Preclinical grade CL429	VacciGrade™	20 – 50 µg/mouse	5 mg	vac-c429
CL531	PAM2CK4-conjugated hydroxyadenine compound	TLR2 +/ TLR4 –	5 pg – 10 µg/ml	500 µg	tlrl-c531
CL572	Monoacyl-ethyl-cystein hydroxyadenine compound	TLR2 +/ TLR4 –	0.5 ng – 1 µg/ml	500 µg	tlrl-c572
FSL-1	Synthetic diacylated lipoprotein – TLR2/6	TLR2 +/ TLR4 –	1 – 100 ng/ml	100 µg	tlrl-fsl
HKBF	Heat Killed Bacteroides fragilis	TLR2 +/ TLR4 –	106 – 107 cells/m	109 cells	tlrl-hkbf
HKEB	Heat Killed Escherichia coli 0111:B4	TLR2 +/ TLR4 +	105 – 107 cells/ml	1010 cells	tlrl-hkeb
HKLM	Heat Killed Listeria monocytogenes	TLR2 +/ TLR4 –	107 – 108 cells/ml	1010 cells	tlrl-hklm
HKLR	Heat Killed Lactobacillus rhamnosus	TLR2 +/ TLR4 –	108 – 109 cells/ml	1010 cells	tlrl-hklr
HKMT	Heat Killed Mycobacterium tuberculosis	TLR2 +/ TLR4 –	100 ng – 10 µg/ml	10 mg 50 mg	tlrl-hkmt-1 tlrl-hkmt-5
HKPA	Heat Killed Pseudomonas aeruginosa	TLR2 +/ TLR4 –	105 – 107 cells/ml	1010 cells	tlrl-hkpa
HKSA	Heat Killed Staphylococcus aureus	TLR2 +/ TLR4 –	106 – 108 cells/ml	1010 cells	tlrl-hksa
HKSE	Heat Killed Staphylococcus epidermidis	TLR2 +/ TLR4 –	107 – 109 cells/ml	1010 cells	tlrl-hkse
HKSP	Heat Killed Streptococcus pneumoniae	TLR2 +/ TLR4 –	107 – 109 cells/ml	1010 cells	tlrl-hksp
HKST	Heat Killed Salmonella typhimurium	TLR2 +/ TLR4 +	104 – 109 cells/ml	1010 cells	tlrl-hkst
LPS-PG	Standard Lipopolysaccharide from P. gingivalis	TLR2 +/ TLR4 +	10 ng – 10 mg/ml	1 mg	tlrl-pglps
LTA-BS	Lipoteichoic acid from Bacillus subtilis	TLR2 +/ TLR4 +	100 ng – 1 µg/ml	5 mg	tlrl-lta
LTA-SA	Lipoteichoic acid from S. aureus	TLR2 +/ TLR4 +	100 ng – 1 µg/ml	5 mg	tlrl-slta
LTA-SA Purified	Purified lipoteichoic acid from S. aureus	TLR2 +/ TLR4 –	1 ng – 1 µg/ml	5 mg	tlrl-pslta
Pam2CSK4	Synthetic diacylated lipoprotein – TLR2(6)	TLR2 +/ TLR4 –	1 – 100 ng/ml	1 mg	tlrl-pm2s-1
Pam3CSK4	Synthetic triacylated lipoprotein – TLR1/2	TLR2 +/ TLR4 –	1 – 300 ng/ml	1 mg	tlrl-pms
Pam3CSK4 Biotin	Biotinylated Pam3CSK4	TLR2 +/ TLR4 –	10 – 300 ng/ml	50 µg	tlrl-bpms
Pam3CSK4 Rhodamine	Rhodamine-labeled Pam3CSK4	TLR2 +/ TLR4 –	1 – 300 ng/ml	50 µg	tlrl-rpms
Pam3CSK4 VacciGrade™	Preclinical grade Pam3CSK4	VacciGrade™	2 – 20 µg/mouse	1 mg	vac-pms
PGN-BS	Peptidoglycan from B. subtilis	TLR2 +/ TLR4 –	1 – 10 µg/ml	5 mg	tlrl-pgnb3
PGN-EB	Peptidoglycan from E. coli 0111:B4	TLR2 +/ TLR4 +	1 – 10 µg/ml	1 mg	tlrl-pgneb
PGN-EK	Peptidoglycan from E. coli K12	TLR2 +/ TLR4 +	1 – 10 µg/ml	1 mg	tlrl-pgnek
PGN-SA	Peptidoglycan from S. aureus	TLR2 +/ TLR4 –	0.1 – 10 µg/ml	5 mg	tlrl-pgns2
Zymosan	Cell wall preparation of S. cerevisiae	TLR2 +/ TLR4 –	1-10 µg/ml	100 mg	tlrl-zyn

更多详情请咨询Invivogen代理商-上海金畔生物

PRR报告基因细胞：TLR, CLR, NOD

发表于2024年6月8日由上海金畔生物科技有限公司

PRR报告基因细胞：TLR, CLR, NOD

促炎反应是由先天性免疫系统中特定的模式识别受体（PRRs）识别病原相关模式分子（PAMPs）所引起的。

InvivoGen提供一系列完整的人源及鼠源报告细胞系旨在表达主要的模式识别受体家族：Toll样受体（TLRs）、NOD样受体（NLRs）、RIG-I样受体（RLRs）、C型凝集素受体（CLRs）、和胞质DNA感受器（CDS）/干扰素基因刺激分子（STING）以及新型细胞质糖传感器：ALPK1 (alphakinase 1) 和 TIFA (TRAF-interacting protein with forkhead-associated domain)。

PRR报告基因细胞系不仅可以过表达所需的PRR表达基因，也可以敲除或敲入该基因。

所有细胞系均通过不同方法进行严格的生物活性检测（PCR, DNA测序，Western- Blot, FACS以及功能验证）

PRR报告基因细胞：TLR, CLR, NOD

详情请联系 Invivogen 全国代理-上海金畔生物科技

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标签归档：tlr

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