SDZ-201106 (±), (DPI-201106)CAS号： 97730-95-5分子式： C29H30N4O2分子量： 466.6描述应用纯度使用方法储存/保存方法密度熔点沸点折射率PK值Ki 数据可溶性/溶解性PubChem CID
| 产品描述 | |
| 描述 |
SDZ-201106 (±), (DPI-201106) is a Diphenylpiperazinylindole derivative. Positive inotropic and calcium sensitizing agent. Increases action potential duration (APD) of heart muscle. DPI 201-106 has been shown to increase the probability of the open state of the Na+ channel, thus increasing the force of the contraction. Used to study mechanisms of restoring the myofibrillar Ca2+ sensitivity and myosin enzymatic activity in diseased human hearts. Has both electron-donor and electron-acceptor activity. |
| 应用 |
A positive inotropic and calcium sensitizing agent
|
| 纯度 |
99%
|
| 使用方法 |
Store solutions at 20°C for up to 3 months.
|
| 储存/保存方法 |
Store at -20° C
|
| 基本信息 | |
| 密度 |
1.29 g/cm3 (Predicted)
|
| 熔点 |
282.96° C (Predicted)
|
| 沸点 |
702.59° C at 760 mmHg (Predicted)
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| 折射率 |
n20D 1.69 (Predicted)
|
| PK值 |
pKa: 13.99, pKb: 6.57
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| Ki 数据 |
Beta-2 adrenergic receptor: Ki= 57.3 nM (human)
|
| 可溶性/溶解性 |
Soluble in water (700 mg/L at 25 °C), chloroform (44.51 g/100mL at 25 °C), dichloromethane (19.20 g/100mL at 25 °C), methanol (9.98 g/100mL at 25 °C), DMSO (50 mM), ethanol (1.28 g/100mL at 25 °C)
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| PubChem CID |
5190
|
