BioXCell热销产品–RecombiMAb anti-mouse VEGFR-2

发表于2024年6月20日由上海金畔生物科技有限公司

BioXCell热销产品–RecombiMAb anti-mouse VEGFR-2

产品描述：

DC101-CP132单克隆抗体是原始DC101单克隆的重组嵌合型抗体。可变结构域序列与原始DC101相同，但是恒定区序列已经从大鼠IgG1变为小鼠IgG2a。DC101-CP132单克隆抗体像原始大鼠IgG1抗体一样，不包含Fc突变。

DC101-CP132单克隆抗体能与小鼠VEGFR-2(血管内皮生长因子受体2)反应，VEGFR-2也称为CD309、KDR和Flk-1。VEGFR-2是酪氨酸蛋白激酶家族的成员。当结合到其配体血管内皮生长因子时发挥生理作用，血管内皮生长因子受体-2在血管发育和通透性中起关键作用。血管内皮生长因子受体-2在成人心脏、肺、肾、脑和骨骼肌的内皮细胞中高表达，在其他组织中低表达。DC101单克隆抗体已被证明在体内抑制VEGFR-2信号传导。

BioXCell热销产品--RecombiMAb anti-mouse VEGFR-2

产品详情：

产品名称	RecombiMAb anti-mouse VEGFR-2
产品货号	CP132
产品规格	1/5/25/50/100mg
反应种属	Mouse
克隆号	DC101-CP132
同种型	Mouse IgG2a(switched from rat IgG1)
免疫原	Mouse VEGFR-2-SEAPs soluble receptor
实验应用	in vivo blocking of VEGF/VEGFR-2 signaling* in vitro blocking of VEGFR signaling* Western blot* *Reported for the original rat IgG1 DC101 antibody
产品形式	PBS, pH 7.0,Contains no stabilizers or preservatives
纯度	>95%, Determined by SDS-PAGE
聚合	<5%, Determined by SEC
无菌处理	0.2 µm filtration
纯化方式	Protein G
分子量	150 kDa
小鼠病原检测	Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative
保存条件	抗体原液保存在4°C，不能冷冻保存。
推荐同型对照	InVivoPlus mouse IgG2a isotype control, unknown specificity（货号BP0085）
推荐抗体稀释液	InVivoPure pH 7.0 Dilution Buffer（货号IP0070）

该产品自上市已被多篇SCI文献引用，品质有保证，以下是部分已发表的文献引用：

应用

文章

体内VEGF/VEGFR-2

信号阻断

(in vivo blocking of

VEGF/VEGFR-2 signaling)

1. Ding, X., et al. (2015). ‘Distinct functions of epidermal and myeloid-derived

VEGF-A in skin tumorigenesis mediated by HPV8′ Cancer Res 75(2): 330-343.

2. Lee, H. J., et al. (2015). ‘Inhibition of vascular endothelial growth factor A and

hypoxia-inducible factor 1alpha maximizes the effects of radiation in sarcoma

mouse models through destruction of tumor vasculature’ Int J Radiat Oncol Biol

Phys 91(3): 621-630.

3. Arulanandam, R., et al. (2015). ‘VEGF-Mediated Induction of PRD1-BF1/Blimp1

Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection’ Cancer Cell

28(2): 210-224.

4. Kizhatil, K., et al. (2014). ‘Schlemm’s canal is a unique vessel with a combination

of blood vascular and lymphatic phenotypes that forms by a novel developmental

process’ PLoS Biol 12(7): e1001912.

体内VEGF/VEGFR-2信号阻断，

体外VEGFR信号阻断

(in vivo blocking of VEGF/VEGFR-2

signaling, in vitro blocking of VEGFR

signaling)

1.Larrayoz, M., et al. (2014). ‘Contrasting responses of non-small cell lung cancer to

antiangiogenic therapies depend on histological subtype’ EMBO Mol Med 6(4): 539-550.

更多产品详情请咨询 BioXCell 中国代理——上海金畔生物

BioXcell热销产品–RecombiMAb anti-mouse PD-1 (CD279) (D265A)

发表于2024年6月20日由上海金畔生物科技有限公司

BioXcell热销产品–RecombiMAb anti-mouse PD-1 (CD279) (D265A)

BioXcell热销产品–RecombiMAb anti-mouse PD-1 (CD279) (D265A)

产品描述：

RMP1-14-CP002单克隆抗体是原始RMP1-14克隆号的重组嵌合型抗体。可变结构域序列与原始RMP1-14克隆号相同，但是恒定区序列已经从大鼠IgG2a变为小鼠IgG1。RMP1-14-CP002单克隆抗体在Fc片段中也含有D265A突变，使其无法与内源性Fcγ受体结合。

RMP1-14-CP002单克隆抗体与小鼠PD-1（程序性死亡-1蛋白，也称为CD279）反应。PD-1是一种50-55 kDa的细胞表面受体，由Pdcd1基因编码，属于免疫球蛋白超家族的CD28家族。PD-1在CD4和CD8胸腺细胞以及活化的T和B淋巴细胞和骨髓细胞上瞬时表达。成功清除抗原后，PD-1表达下降。此外，Pdcd1 mRNA在前B细胞阶段在发育中的B淋巴细胞中表达。PD-1的结构包括一个ITIM(免疫受体酪氨酸抑制基序),表明PD-1负调节TCR信号。PD-1通过结合它的两个配体PD-L1和PD-L2发出信号，这两个配体都是B7家族的成员。配体结合后，PD-1信号抑制T细胞活化，导致增殖、细胞因子产生和T细胞死亡减少。此外，已知PD-1在小鼠的外周耐受性和预防自身免疫性疾病中起关键作用，因为PD-1敲除动物表现出扩张性心肌病、脾肿大和外周耐受性丧失。诱导的PD-L1表达常见于许多肿瘤，包括鳞状细胞癌、结肠腺癌和乳腺腺癌。PD-L1过度表达导致肿瘤细胞对CD8 T细胞介导的裂解的抗性增加。在黑色素瘤的小鼠模型中，通过用阻断PD-L1和它的受体PD-1之间的相互作用的抗体治疗，肿瘤生长可以暂时被抑制。目前PD-1是免疫疗法作为癌症治疗的热门靶点之一。

产品详情：

产品名称	RecombiMAb anti-mouse PD-1 (CD279) (D265A)
产品货号	CP002
产品规格	1mg
反应种属	Mouse
克隆号	RMP1-14-CP002
同种型	Mouse IgG1(switched from rat IgG2a)
免疫原	Syrian Hamster BKH cells transfected with mouse PD-1 cDNA
实验应用	in vivo blocking of PD-1/PD-L signaling* *Reported for the original rat IgG2a RMP1-14 antibody
产品形式	PBS, pH 7.0,Contains no stabilizers or preservatives
纯度	>95%, Determined by SDS-PAGE
聚合	<5%, Determined by SEC
无菌处理	0.2 µm filtration
纯化方式	Protein G
分子量	150 kDa
小鼠病原检测	Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative
保存条件	抗体原液保存在4°C，不能冷冻保存。
推荐抗体稀释液	InVivoPure pH 7.0 Dilution Buffer（货号IP0070）

该产品自上市已被多篇SCI文献引用，品质有保证，以下是部分已发表的文献引用：

应用

文章

体内PD-1/PD-L信号阻断

(in vivo blocking of PD-1/PD-L

signaling)

1. Triplett, T. A., et al. (2018). ‘Reversal of indoleamine 2,3-dioxygenase-mediated cancer

immune suppression by systemic kynurenine depletion with a therapeutic enzyme’ Nat

Biotechnol 36(8): 758-764.

2. Grasselly, C., et al. (2018). ‘The Antitumor Activity of Combinations of Cytotoxic

Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent’ Front Immunol 9: 2100.

3. Moynihan, K. D., et al. (2016). ‘Eradication of large established tumors in mice by

combination immunotherapy that engages innate and adaptive immune responses’ Nat

Med. doi : 10.1038/nm.4200.

4. Ngiow, S. F., et al. (2015). ‘A Threshold Level of Intratumor CD8+ T-cell PD1 Expression

Dictates Therapeutic Response to Anti-PD1′ Cancer Res 75(18): 3800-3811.

5. Evans, E. E., et al. (2015). ‘Antibody Blockade of Semaphorin 4D Promotes Immune

Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies’

Cancer Immunol Res 3(6): 689-701.

6. Zelenay, S., et al. (2015). ‘Cyclooxygenase-Dependent Tumor Growth through Evasion

of Immunity’ Cell 162(6): 1257-1270.

7. Zander, R. A., et al. (2015). ‘PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk

Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity’ Cell

Host Microbe 17(5): 628-641.

更多产品详情请咨询 BioXCell 中国代理——上海金畔生物

BioXCell热销产品–RecombiMAb anti-mouse PD-L1 (B7-H1) (D265A)

发表于2024年6月20日由上海金畔生物科技有限公司

BioXCell热销产品–RecombiMAb anti-mouse PD-L1 (B7-H1) (D265A)

BioXCell热销产品–RecombiMAb anti-mouse PD-L1 (B7-H1) (D265A)

产品描述：

10F.9G2™-CP001单克隆抗体是原始10F.9G2™单克隆抗体的重组嵌合型抗体。可变结构域序列与原始10F.9G2™克隆号相同，但是恒定区序列已经从大鼠IgG2b变为小鼠IgG1。10F.9G2™-CP001单克隆抗体在Fc片段中也含有D265A突变，使其无法与内源性Fcγ受体结合。

10F.9G2™-CP001单克隆抗体与小鼠PD-L1（程序性死亡配体1，也称为B7-H1或CD274）反应。PD-L1是属于Ig超家族的B7家族的I型跨膜蛋白，分子量为40kDa。PD-L1在T淋巴细胞、B淋巴细胞、NK细胞、树突状细胞以及IFNγ刺激的单核细胞、上皮细胞和内皮细胞上表达。PD-L1与CD4和CD8胸腺细胞以及活化的T和B淋巴细胞和骨髓细胞上的受体PD-1结合。PD-L1与PD-1的结合导致抑制TCR介导的T细胞增殖和细胞因子产生。PD-L1被认为在肿瘤免疫逃逸中起着重要作用。诱导的PD-L1表达在许多肿瘤中很常见，并导致肿瘤细胞对CD8+ T细胞介导的裂解的抗性增加。在黑色素瘤的小鼠模型中，可以通过用阻断PD-L1和PD-1之间相互作用的抗体进行治疗，暂时抑制肿瘤生长。10F.9G2™单克隆抗体已被证明可以阻断PD-L1和PD-1之间以及PD-L1和B7-1之间的相互作用（CD80）。

产品详情：

产品名称	RecombiMAb anti-mouse PD-L1 (B7-H1) (D265A)
产品货号	CP001
产品规格	1mg
反应种属	Mouse
克隆号	10F.9G2™-CP001
同种型	Mouse IgG1(switched from rat IgG2b)
免疫原	Mouse CD274
实验应用	in vivo PD-L1 blockade* Immunofluorescence* Immunohistochemistry (frozen)* Flow cytometry* Western blot* *Reported for the original rat IgG2b 10F.9G2 antibody
产品形式	PBS, pH 7.0,Contains no stabilizers or preservatives
纯度	>95%, Determined by SDS-PAGE
聚合	<5%, Determined by SEC
无菌处理	0.2 µm filtration
纯化方式	Protein A
分子量	150 kDa
小鼠病原检测	Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative
保存条件	抗体原液保存在4°C，不能冷冻保存。
推荐抗体稀释液	InVivoPure pH 7.0 Dilution Buffer（货号IP0070）

该产品自上市已被多篇SCI文献引用，品质有保证，以下是部分已发表的文献引用：

应用

文章

体内PD-L1阻断

(in vivo PD-L1 blockade)

1. Grasselly, C., et al. (2018). ‘The Antitumor Activity of Combinations of Cytotoxic

Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent’ Front

Immunol 9: 2100.

2. Stathopoulou, C., et al. (2018). ‘PD-1 Inhibitory Receptor Downregulates Asparaginyl

Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory

T Cells’ Immunity 49(2): 247-263 e247.

3. Jaworska, K., et al. (2015). ‘Both PD-1 ligands protect the kidney from ischemia

reperfusion injury’ J Immunol 194(1): 325-333.

4. Kim, J., et al. (2015). ‘Memory programming in CD8(+) T-cell differentiation is

intrinsic and is not determined by CD4 help’ Nat Commun 6: 7994.

5. Zander, R. A., et al. (2015). ‘PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk

Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity’ Cell

Host Microbe 17(5): 628-641.

体内PD-L1阻断，流式细胞术

(in vivo PD-L1 blockade, Flow

Cytometry)

1. Aloulou, M., et al. (2016). ‘Follicular regulatory T cells can be specific for the

immunizing antigen and derive from naive T cells’ Nat Commun 7: 10579.

2. Ngiow, S. F., et al. (2015). ‘A Threshold Level of Intratumor CD8+ T-cell PD1

Expression Dictates Therapeutic Response to Anti-PD1′ Cancer Res 75(18): 3800-3811.

3. Rutigliano, J. A., et al. (2014). ‘Highly pathological influenza A virus infection is

associated with augmented expression of PD-1 by functionally compromised

virus-specific CD8+ T cells’ J Virol 88(3): 1636-1651.

体内PD-L1阻断，免疫荧光

(in vivo PD-L1 blockade,

Immunofluorescence)

1.Willimsky, G., et al. (2013). ‘Virus-induced hepatocellular carcinomas cause

antigen-specific local tolerance’ J Clin Invest 123(3): 1032-1043.

免疫组织化学（冷冻），免疫荧光

(Immunohistochemistry (frozen),

Immunofluorescence)

1.Riella, L. V., et al. (2011). ‘Essential role of PDL1 expression on nonhematopoietic

donor cells in acquired tolerance to vascularized cardiac allografts’ Am J Transplant

11(4): 832-840.

更多产品详情请咨询 BioXCell 中国代理——上海金畔生物

BioXCell热销产品–RecombiMAb anti-mouse VEGFR-2

发表于2024年6月20日由上海金畔生物科技有限公司

BioXCell热销产品–RecombiMAb anti-mouse VEGFR-2

产品描述：

产品详情：

产品名称	RecombiMAb anti-mouse VEGFR-2
产品货号	CP132
产品规格	1/5/25/50/100mg
反应种属	Mouse
克隆号	DC101-CP132
同种型	Mouse IgG2a(switched from rat IgG1)
免疫原	Mouse VEGFR-2-SEAPs soluble receptor
实验应用	in vivo blocking of VEGF/VEGFR-2 signaling* in vitro blocking of VEGFR signaling* Western blot* *Reported for the original rat IgG1 DC101 antibody
产品形式	PBS, pH 7.0,Contains no stabilizers or preservatives
纯度	>95%, Determined by SDS-PAGE
聚合	<5%, Determined by SEC
无菌处理	0.2 µm filtration
纯化方式	Protein G
分子量	150 kDa
小鼠病原检测	Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative
保存条件	抗体原液保存在4°C，不能冷冻保存。
推荐同型对照	InVivoPlus mouse IgG2a isotype control, unknown specificity（货号BP0085）
推荐抗体稀释液	InVivoPure pH 7.0 Dilution Buffer（货号IP0070）

该产品自上市已被多篇SCI文献引用，品质有保证，以下是部分已发表的文献引用：

应用

文章

体内VEGF/VEGFR-2信号阻断

(in vivo blocking of VEGF/VEGFR-2 signaling)

1. Ding, X., et al. (2015). ‘Distinct functions of epidermal and myeloid-derived VEGF-A in skin tumorigenesis mediated by HPV8’ Cancer Res 75(2): 330-343.

2. Lee, H. J., et al. (2015). ‘Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1alpha maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature’ Int J Radiat Oncol Biol Phys 91(3): 621-630.

3. Arulanandam, R., et al. (2015). ‘VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection’ Cancer Cell 28(2): 210-224.

4. Kizhatil, K., et al. (2014). ‘Schlemm’s canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process’ PLoS Biol 12(7): e1001912.

体内VEGF/VEGFR-2信号阻断，体外VEGFR信号阻断

(in vivo blocking of VEGF/VEGFR-2 signaling, in vitro blocking of VEGFR signaling)

1.Larrayoz, M., et al. (2014). ‘Contrasting responses of non-small cell lung cancer to antiangiogenic therapies depend on histological subtype’ EMBO Mol Med 6(4): 539-550.

更多产品详情请咨询 BioXCell 中国代理——上海金畔生物

BioXCell热销产品–RecombiMAb anti-mouse CTLA-4 (CD152)

发表于2024年6月19日由上海金畔生物科技有限公司

BioXCell热销产品–RecombiMAb anti-mouse CTLA-4 (CD152)

产品描述：

9D9-CP006单克隆抗体是原始9D9单克隆抗体的重组嵌合型抗体。可变结构域序列与原始9D9克隆号相同，但是恒定区序列已经从小鼠IgG2b变为小鼠IgG1。9D9-CP006单克隆抗体能与小鼠CTLA-4(细胞毒性T淋巴细胞抗原-4)反应，CTLA-4也称为CD152。CTLA-4是一种33 kDa的细胞表面受体，由属于免疫球蛋白超家族CD28家族的Ctla4基因编码。CTLA-4在活化的T淋巴细胞和B淋巴细胞上表达。CTLA-4在结构上类似于T细胞共刺激蛋白CD28，两种分子都与B7家族成员B7-1 (CD80)和B7-2 (CD86)结合。在与配体结合时，CTLA-4负调节细胞介导的免疫反应。CTLA-4在诱导和/或维持免疫耐受、胸腺细胞发育和保护性免疫调节中起作用。CTLA-4在免疫下调中的关键作用已经在CTLA-4缺陷小鼠中得到证实，这些小鼠在3-5周龄时由于淋巴增生性疾病的发展而死亡。CTLA-4是目前肿瘤免疫检查点治疗的热门靶点之一。

产品详情：

产品名称	RecombiMAb anti-mouse CTLA-4 (CD152)
产品货号	CP006
产品规格	1mg
反应种属	Mouse
克隆号	9D9-CP006
同种型	Mouse IgG1(switched from mouse IgG2b)
免疫原	Not available or unknown
实验应用	in vivo CTLA-4 neutralization* Western blot* *Reported for the original mouse IgG2b 9D9 antibody
产品形式	PBS, pH 7.0,Contains no stabilizers or preservatives
纯度	>95%, Determined by SDS-PAGE
聚合	<5%, Determined by SEC
无菌处理	0.2 µm filtration
纯化方式	Protein G
分子量	150 kDa
小鼠病原检测	Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative
保存条件	抗体原液保存在4°C，不能冷冻保存。
推荐同型对照	InVivoPlus mouse IgG1 isotype control, unknown specificity（货号BP0083）
推荐抗体稀释液	InVivoPure pH 7.0 Dilution Buffer（货号IP0070）

该产品自上市已被多篇SCI文献引用，品质有保证，以下是部分已发表的文献引用：

应用

文章

体内CTLA-4中和

(in vivo CTLA-4

neutralization)

1. Dai, M., et al. (2015). ‘Curing mice with large tumors by locally delivering

combinations of immunomodulatory antibodies’ Clin Cancer Res 21(5): 1127-1138.

2. Zippelius, A., et al. (2015). ‘Induced PD-L1 expression mediates acquired

resistance to agonistic anti-CD40 treatment’ Cancer Immunol Res 3(3): 236-244.

3. Redmond, W. L., et al. (2014). ‘Combined targeting of costimulatory (OX40)

and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of

driving robust antitumor immunity’ Cancer Immunol Res 2(2): 142-153.

4. Condamine, T., et al. (2014). ‘ER stress regulates myeloid-derived suppressor

cell fate through TRAIL-R-mediated apoptosis’ J Clin Invest 124(6): 2626-2639.

5. Muller, P., et al. (2014). ‘Microtubule-depolymerizing agents used in antibody-drug

conjugates induce antitumor immunity by stimulation of dendritic cells’ Cancer Immunol

Res 2(8): 741-755.

6. Bulliard, Y., et al. (2013). ‘Activating Fc gamma receptors contribute to the antitumor

activities of immunoregulatory receptor-targeting antibodies’ J Exp Med 210(9): 1685-1693.

更多产品详情请咨询 BioXCell 中国代理——上海金畔生物

BioXCell热销产品–CP005 RecombiMAb anti-mouse PD-1 (CD279) (D265A)

发表于2024年6月18日由上海金畔生物科技有限公司

BioXCell热销产品–CP005 RecombiMAb anti-mouse PD-1 (CD279) (D265A)

BioXCell热销产品–CP005 RecombiMAb anti-mouse PD-1 (CD279) (D265A)

产品描述：

29F.1A12™-CP005单克隆抗体是原始29F.1A12™的重组嵌合型抗体。可变结构域序列与原始29F.1A12™相同，但是恒定区序列已经从大鼠IgG2a变为小鼠IgG1。29F.1A12™-CP004抗体在Fc片段中也含有D265A突变，使其无法与内源性Fcγ受体结合。

29F.1A12™-CP005单克隆抗体与小鼠PD-1（程序性死亡-1蛋白，也称为CD279）反应。PD-1是一种50-55 kDa的细胞表面受体，由Pdcd1基因编码，属于免疫球蛋白超家族的CD28家族。PD-1在CD4和CD8胸腺细胞以及活化的T和B淋巴细胞和骨髓细胞上瞬时表达。成功清除抗原后，PD-1表达下降。此外，Pdcd1 mRNA在前B细胞阶段在发育中的B淋巴细胞中表达。PD-1的结构包括一个ITIM(免疫受体酪氨酸抑制基序),表明PD-1负调节TCR信号。PD-1通过结合它的两个配体PD-L1和PD-L2发出信号，这两个配体都是B7家族的成员。配体结合后，PD-1信号抑制T细胞活化，导致增殖、细胞因子产生和T细胞死亡减少。此外，已知PD-1在小鼠的外周耐受性和预防自身免疫性疾病中起关键作用，因为PD-1敲除动物表现出扩张性心肌病、脾肿大和外周耐受性丧失。诱导的PD-L1表达常见于许多肿瘤，包括鳞状细胞癌、结肠腺癌和乳腺腺癌。PD-L1过度表达导致肿瘤细胞对CD8 T细胞介导的裂解的抗性增加。在黑色素瘤的小鼠模型中，通过用阻断PD-L1和它的受体PD-1之间的相互作用的抗体治疗方法，肿瘤生长可以暂时被抑制。由于这些研究成果，PD-1目前成为探索抗肿瘤免疫疗法的热门靶点。

产品详情：

产品名称	RecombiMAb anti-mouse PD-1 (CD279) (D265A)
产品货号	CP005
产品规格	1mg
反应种属	Mouse
克隆号	29F.1A12™-CP005
同种型	Mouse IgG1(switched from rat IgG2a)
免疫原	Recombinant PD-1-Ig fusion protein
实验应用	in vivo blocking of PD-1/PD-L signaling* in vitro PD-1 neutralization* Immunohistochemistry (frozen)* Immunofluorescence* Western blot* Flow cytometry* *Reported for the original rat IgG2a 29F.1A12 antibody
产品形式	PBS, pH 7.0,Contains no stabilizers or preservatives
纯度	>95%, Determined by SDS-PAGE
聚合	<5%, Determined by SEC
无菌处理	0.2 µm filtration
纯化方式	Protein G
分子量	150 kDa
小鼠病原检测	Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative
保存条件	抗体原液保存在4°C，不能冷冻保存。
推荐抗体稀释液	InVivoPure pH 7.0 Dilution Buffer（货号IP0070）

该产品自上市已被多篇SCI文献引用，品质有保证，以下是部分已发表的文献引用：

应用

文章

体内PD-1/PD-L信号阻断

(in vivo blocking of

PD-1/PD-L signaling)

1. Wang, W., et al. (2018). ‘RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in

Pancreatic Cancer’ Cancer Cell 34(5): 757-774 e757.

2. Gordon, S. R., et al. (2017). ‘PD-1 expression by tumour-associated macrophages inhibits phagocytosis

and tumour immunity’ Nature 545(7655): 495-499.

3. Koyama, S., et al. (2016). ‘STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory

Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment’ Cancer Res 76(5):

999-1008.

体内PD-1/PD-L信号阻断，

流式细胞术

(in vivo blocking of

PD-1/PD-L signaling,

Flow Cytometry)

1.Koyama, S., et al. (2016). ‘Adaptive resistance to therapeutic PD-1 blockade is associated with

upregulation of alternative immune checkpoints’ Nat Commun 7: 10501.

体外PD-1中和

（in vitro PD-1 neutralization）

1.Park, S. J., et al. (2014). ‘Negative role of inducible PD-1 on survival of activated dendritic cells’ J

Leukoc Biol 95(4): 621-629.

流式细胞术

（Flow Cytometry）

1.Good-Jacobson, K. L., et al. (2012). ‘CD80 expression on B cells regulates murine T follicular

helper development, germinal center B cell survival, and plasma cell generation’ J Immunol 188(9):

4217-4225.

免疫荧光，蛋白质印迹

(Immunofluorescence,

Western Blot)

1.Chen, L., et al. (2009). ‘Role of the immune modulator programmed cell death-1 during development and

apoptosis of mouse retinal ganglion cells’ Invest Ophthalmol Vis Sci 50(10): 4941-4948.

更多产品详情请咨询 BioXCell 中国代理——上海金畔生物

BioXCell热销产品–RecombiMAb anti-mouse CD40

发表于2024年6月18日由上海金畔生物科技有限公司

BioXCell热销产品–RecombiMAb anti-mouse CD40

产品描述：

FGK4.5-CP133单克隆抗体是原始FGK4.5单克隆抗体的重组嵌合型抗体。可变结构域序列与原始FGK4.5克隆号相同，但是恒定区序列已经从大鼠IgG2a变为小鼠IgG2a。FGK4.5-CP133抗体像原始大鼠IgG2a抗体一样，不包含Fc突变。

FGK4.5-CP133单克隆抗体能与小鼠CD40(也称为Bp50)反应。CD40是一种48 kDa的I型跨膜糖蛋白，属于肿瘤坏死因子受体(TNFR)超家族。CD40广泛表达于抗原呈递细胞(APCs)，如树突状细胞、B细胞、巨噬细胞和单核细胞，以及非免疫内皮细胞、基底上皮细胞和一系列肿瘤细胞上。CD40与其配体CD154结合后，作为共刺激分子激活B细胞、树突状细胞、单核细胞和其他APCs。CD40在B细胞活化、分化、增殖和免疫球蛋白同种型转换以及树突状细胞成熟中起作用。激动性CD40单克隆抗体已被证明能激活APCs并促进抗肿瘤T细胞反应。FGK4.5单克隆抗体是一种激动性抗体，已被证明能激活表达CD40的APC。FGK4.5单克隆抗体也可用于体外和体内抑制CD40/CD154相互作用。

BioXCell热销产品--RecombiMAb anti-mouse CD40

产品详情：

产品名称	RecombiMAb anti-mouse CD40
产品货号	CP133
产品规格	1/5/25/50/100mg
反应种属	Mouse
克隆号	FGK4.5-CP133
同种型	Mouse IgG2a(switched from rat IgG2a)
免疫原	Recombinant mouse CD40 fusion protein
实验应用	in vivo CD40 activation* in vitro B cell stimulation/activation* *Reported for the original rat IgG2a FGK4.5 antibody
产品形式	PBS, pH 7.0,Contains no stabilizers or preservatives
纯度	>95%, Determined by SDS-PAGE
聚合	<5%, Determined by SEC
无菌处理	0.2 µm filtration
纯化方式	Protein G
分子量	150 kDa
小鼠病原检测	Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative
保存条件	抗体原液保存在4°C，不能冷冻保存。
推荐同型对照	InVivoPlus mouse IgG2a isotype control, unknown specificity（货号BP0085）
推荐抗体稀释液	InVivoPure pH 7.0 Dilution Buffer（货号IP0070）

该产品自上市已被多篇SCI文献引用，品质有保证，以下是部分已发表的文献引用：

应用

文章

体内CD40激活

(in vivo CD40 activation)

1. Bauche, D., et al. (2018). ‘LAG3(+) Regulatory T Cells Restrain Interleukin-23-

Producing CX3CR1(+) Gut-Resident Macrophages during Group 3 Innate Lymphoid

Cell-Driven Colitis’ Immunity 49(2): 342-352 e345.

2. Carmi, Y., et al. (2015). ‘Allogeneic IgG combined with dendritic cell stimuli induce

antitumour T-cell immunity’ Nature 521(7550): 99-104.

3. Conde, P., et al. (2015). ‘DC-SIGN(+) Macrophages Control the Induction of

Transplantation Tolerance’ Immunity 42(6): 1143-1158.

4. Bartkowiak, T., et al. (2015). ‘Unique potential of 4-1BB agonist antibody to promote

durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine’ Proc

Natl Acad Sci U S A 112(38): E5290-5299.

体外B细胞刺激/激活

(in vitro B cell stimulation/activation)

1. Xu, H., et al. (2015). ‘Regulation of bifurcating B cell trajectories by mutual antagonism

between transcription factors IRF4 and IRF8′ Nat Immunol .

2. Muppidi, J. R., et al. (2014). ‘Loss of signalling via Galpha13 in germinal centre

B-cell-derived lymphoma’ Nature 516(7530): 254-258.

更多产品详情请咨询 BioXCell 中国代理——上海金畔生物

BioXCell热销产品–RecombiMAb anti-mouse CTLA-4 (CD152) (LALA-PG)

发表于2024年6月18日由上海金畔生物科技有限公司

BioXCell热销产品–RecombiMAb anti-mouse CTLA-4 (CD152) (LALA-PG)

产品描述：

9D9-CP008单克隆抗体是原始9D9单克隆抗体的重组嵌合型抗体。可变结构域序列与原始9D9克隆号相同，但是恒定区序列已经从小鼠IgG2b变为小鼠IgG2a。9D9-CP008单克隆抗体在Fc片段中也含有LALA-PG突变，使其无法与内源性Fcγ受体结合。

9D9-CP008单克隆抗体能与小鼠CTLA-4(细胞毒性T淋巴细胞抗原-4)反应，CTLA-4也称为CD152。CTLA-4是一种33 kDa的细胞表面受体，由属于免疫球蛋白超家族CD28家族的Ctla4基因编码。CTLA-4在活化的T淋巴细胞和B淋巴细胞上表达。CTLA-4在结构上类似于T细胞共刺激蛋白CD28，两种分子都与B7家族成员B7-1 (CD80)和B7-2 (CD86)结合。在与配体结合时，CTLA-4负调节细胞介导的免疫反应。CTLA-4在诱导和/或维持免疫耐受、胸腺细胞发育和保护性免疫调节中起作用。CTLA-4在免疫下调中的关键作用已经在CTLA-4缺陷小鼠中得到证实，这些小鼠在3-5周龄时由于淋巴增生性疾病的发展而死亡。CTLA-4目前是肿瘤免疫治疗中的热门免疫检查点靶点之一。

产品详情：

产品名称	RecombiMAb anti-mouse CTLA-4 (CD152) (LALA-PG)
产品货号	CP008
产品规格	1mg
反应种属	Mouse
克隆号	9D9-CP008
同种型	Mouse IgG2b(switched from mouse IgG2a)
免疫原	Not available or unknown
实验应用	in vivo CTLA-4 neutralization* Western blot* *Reported for the original mouse IgG2b 9D9 antibody
产品形式	PBS, pH 7.0,Contains no stabilizers or preservatives
纯度	>95%, Determined by SDS-PAGE
聚合	<5%, Determined by SEC
无菌处理	0.2 µm filtration
纯化方式	Protein A
分子量	150 kDa
小鼠病原检测	Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative
保存条件	抗体原液保存在4°C，不能冷冻保存。
推荐抗体稀释液	InVivoPure pH 7.0 Dilution Buffer（货号IP0070）

该产品自上市已被多篇SCI文献引用，品质有保证，以下是部分已发表的文献引用：

应用

文章

体内CTLA-4中和

(in vivo CTLA-4

neutralization)

1. Dai, M., et al. (2015). ‘Curing mice with large tumors by locally

delivering combinations of immunomodulatory antibodies’

Clin Cancer Res 21(5): 1127-1138.

2. Zippelius, A., et al. (2015). ‘Induced PD-L1 expression mediates

acquired resistance to agonistic anti-CD40 treatment’ Cancer Immunol

Res 3(3): 236-244.

3. Redmond, W. L., et al. (2014). ‘Combined targeting of costimulatory

(OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T

cells capable of driving robust antitumor immunity’ Cancer Immunol

Res 2(2): 142-153.

4. Condamine, T., et al. (2014). ‘ER stress regulates myeloid-derived

suppressor cell fate through TRAIL-R-mediated apoptosis’ J Clin Invest

124(6): 2626-2639.

5. Muller, P., et al. (2014). ‘Microtubule-depolymerizing agents used in

antibody-drug conjugates induce antitumor immunity by stimulation of

dendritic cells’ Cancer Immunol Res 2(8): 741-755.

6. Bulliard, Y., et al. (2013). ‘Activating Fc gamma receptors contribute

to the antitumor activities of immunoregulatory receptor-targeting

antibodies’ J Exp Med 210(9): 1685-1693.

更多产品详情请咨询 BioXCell 中国代理——上海金畔生物

BioXCell热销产品–RecombiMAb anti-mouse CSF1R (CD115)

发表于2024年6月18日由上海金畔生物科技有限公司

BioXCell热销产品–RecombiMAb anti-mouse CSF1R (CD115)

产品描述：

AFS98-CP131单克隆抗体是原始AFS98单克隆抗体的重组嵌合型抗体。可变结构域序列与原始AFS98单克隆抗体相同，但是恒定区序列已经从大鼠IgG2a变到小鼠IgG2a。AFS98-CP131单克隆抗体像原始大鼠IgG2a抗体一样，不包含Fc突变。

AFS98-CP131单克隆抗体能与小鼠集落刺激因子1受体(CSF1R)，也称为巨噬细胞集落刺激因子受体(M-CSFR)，即CD115反应。CSF1R是一种单程I型膜蛋白，是血小板衍生生长因子受体家族的成员。在小鼠中，CSF1R由单核细胞/巨噬细胞、腹膜渗出物细胞、浆细胞样和常规树突细胞以及破骨细胞表达。CSF1R是CSF1的受体，CSF1通过CSF1R调节单核细胞谱系中细胞的增殖和分化。据报道，AFS98单克隆抗体可在体内deplete巨噬细胞并阻断CSFR1。

BioXCell热销产品--RecombiMAb anti-mouse CSF1R (CD115)

产品详情：

产品名称	RecombiMAb anti-mouse CSF1R (CD115)
产品货号	CP131
产品规格	1/5/25/50/100mg
反应种属	Mouse
克隆号	AFS98-CP131
同种型	Mouse IgG2a(switched from rat IgG2a)
免疫原	Not available or unknown
实验应用	in vivo macrophage depletion* in vitro CSF1R neutralization* in vivo monocyte depletion* Flow cytometry* Western blot* *Reported for the original rat IgG2a AFS98 antibody
产品形式	PBS, pH 7.0,Contains no stabilizers or preservatives
纯度	>95%, Determined by SDS-PAGE
聚合	<5%, Determined by SEC
无菌处理	0.2 µm filtration
纯化方式	Protein A
分子量	150 kDa
小鼠病原检测	Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative
保存条件	抗体原液保存在4°C，不能冷冻保存。
推荐同型对照	InVivoPlus mouse IgG2a isotype control, unknown specificity（货号BP0085）
推荐抗体稀释液	InVivoPure pH 7.0 Dilution Buffer（货号IP0070）

该产品自上市已被多篇SCI文献引用，品质有保证，以下是部分已发表的文献引用：

应用

文章

体内巨噬细胞耗竭

(in vivo macrophage

depletion)

1. Bauche, D., et al. (2018). ‘LAG3(+) Regulatory T Cells Restrain Interleukin-23-Producing

CX3CR1(+) Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis’

Immunity 49(2): 342-352 e345.

2. Gordon, S. R., et al. (2017). ‘PD-1 expression by tumour-associated macrophages inhibits

phagocytosis and tumour immunity’ Nature 545(7655): 495-499.

3. Moynihan, K. D., et al. (2016). ‘Eradication of large established tumors in mice by combination

immunotherapy that engages innate and adaptive immune responses’ Nat Med. doi : 10.1038/nm.4200.

4. Naik, S., et al. (2015). ‘Commensal-dendritic-cell interaction specifies a unique protective

skin immune signature’ Nature 520(7545): 104-108.

体外CSF-R1中和

(in vitro CSF-R1

neutralization)

1.Sheng, K. C., et al. (2014). ‘IL-3 and CSF-1 interact to promote generation of

CD11c+IL-10-producing macrophages’ PLoS One 9(4): e95208.

流式细胞术

(Flow Cytometry)

1. Li, W., et al. (2012). ‘Intravital 2-photon imaging of leukocyte trafficking in beating

heart’ J Clin Invest 122(7): 2499-2508.

2. Tagliani, E., et al. (2011). ‘Coordinate regulation of tissue macrophage and dendritic

cell population dynamics by CSF-1′ J Exp Med 208(9): 1901-1916.

更多产品详情请咨询 BioXCell 中国代理——上海金畔生物

BioXCell热销产品–RecombiMAb anti-mouse Ly6G

发表于2024年6月18日由上海金畔生物科技有限公司

BioXCell热销产品–RecombiMAb anti-mouse Ly6G

产品描述：

1A8-CP129单克隆抗体是原始1A8单克隆抗体的重组嵌合型抗体。可变结构域序列与原始1A8相同，但是恒定区序列已经从大鼠IgG2a变为小鼠IgG2a。1A8-CP129单克隆抗体像原始克隆号的大鼠IgG2a抗体一样，不包含Fc突变。

1A8-CP129单克隆抗体与小鼠Ly6G反应。Ly6G分子量为21-25kDa，是GPI锚定的细胞表面蛋白Ly-6超家族的成员，在细胞信号传导和细胞粘附中发挥作用。Ly6G在发育过程中由骨髓谱系中的细胞（包括单核细胞、巨噬细胞、粒细胞和嗜中性粒细胞）差异表达。单核细胞通常在发育过程中瞬时表达Ly6G，而成熟的粒细胞和外周嗜中性粒细胞持续表达，使Ly6G成为这些细胞群体的表面标志物。与BioXcell RB6-8C5单克隆抗体不同，1A8-CP129单克隆抗体与小鼠Ly6G特异性反应，而与Ly6C没有交叉反应性的报道。

BioXCell热销产品--RecombiMAb anti-mouse Ly6G

产品详情：

产品名称	RecombiMAb anti-mouse Ly6G
产品货号	CP129
产品规格	1/5/25/50/100mg
反应种属	Mouse
克隆号	1A8-CP129
同种型	Mouse IgG2a(switched from rat IgG2a)
免疫原	EL4J cells transfected with Ly6G
实验应用	in vivo neutrophil depletion* in vivo MDSC depletion* Immunofluorescence* Immunohistochemistry (paraffin)* Immunohistochemistry (frozen)* Flow cytometry* *Reported for the original rat IgG2a 1A8 antibody
产品形式	PBS, pH 7.0,Contains no stabilizers or preservatives
纯度	>95%, Determined by SDS-PAGE
聚合	<5%, Determined by SEC
无菌处理	0.2 µm filtration
纯化方式	Protein G
分子量	150 kDa
小鼠病原检测	Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative
保存条件	抗体原液保存在4°C，不能冷冻保存。
推荐同型对照	InVivoPlus mouse IgG2a isotype control, unknown specificity（货号BP0085）
推荐抗体稀释液	InVivoPure pH 7.0 Dilution Buffer（货号IP0070）

该产品自上市已被多篇SCI文献引用，品质有保证，以下是部分已发表的文献引用：

应用

文章

体内中性粒细胞耗竭

(in vivo neutrophil depletion)

1. Davis, R. W. t., et al. (2018). ‘Luminol Chemiluminescence Reports Photodynamic

Therapy-Generated Neutrophil Activity In Vivo and Serves as a Biomarker of Therapeutic

Efficacy’ Photochem Photobiol .

2. Moynihan, K. D., et al. (2016). ‘Eradication of large established tumors in mice by

combination immunotherapy that engages innate and adaptive immune responses’ Nat Med.

doi : 10.1038/nm.4200.

3. Conde, P., et al. (2015). ‘DC-SIGN(+) Macrophages Control the Induction of Transplantation

Tolerance’ Immunity 42(6): 1143-1158.

4. Griseri, T., et al. (2015). ‘Granulocyte Macrophage Colony-Stimulating Factor-Activated

Eosinophils Promote Interleukin-23 Driven Chronic Colitis’ Immunity 43(1): 187-199.

5. Yamada, D. H., et al. (2015). ‘Suppression of Fcgamma-receptor-mediated antibody

effector function during persistent viral infection’ Immunity 42(2): 379-390.

体内中性粒细胞耗竭、流式细胞术、

免疫组化石蜡切片(in vivo neutrophil

depletion, Flow Cytometry,

Immunohistochemistry (paraffin))

Coffelt, S. B., et al. (2015). ‘IL-17-producing gammadelta T cells and neutrophils conspire

to promote breast cancer metastasis’ Nature 522(7556): 345-348.

体内中性粒细胞耗竭、流式细胞术、

免疫组化石蜡切片、免疫组化冰冻切片

(in vivo neutrophil depletion, Flow

Cytometry, Immunohistochemistry

(paraffin), Immunohistochemistry (frozen)

Finisguerra, V., et al. (2015). ‘MET is required for the recruitment of anti-tumoural

neutrophils’ Nature 522(7556): 349-353.

体内中性粒细胞耗竭、流式细胞术

(in vivo neutrophil depletion,

Flow Cytometry)

1.Moser, E. K., et al. (2014). ‘Late engagement of CD86 after influenza virus

clearance promotes recovery in a FoxP3+ regulatory T cell dependent manner’

PLoS Pathog 10(8): e1004315.

2. Chen, K. W., et al. (2014). ‘The neutrophil NLRC4 inflammasome selectively

promotes IL-1beta maturation without pyroptosis during acute Salmonella

challenge’ Cell Rep 8(2): 570-582.

3. Garraud, K., et al. (2012). ‘Differential role of the interleukin-17 axis and

neutrophils in resolution of inhalational anthrax’ Infect Immun 80(1): 131-142.

体内骨髓来源抑制细胞耗竭

(in vivo MDSC depletion)

Deng, L., et al. (2014). ‘Irradiation and anti-PD-L1 treatment synergistically

promote antitumor immunity in mice’ J Clin Invest 124(2): 687-695.

体内中性粒细胞耗竭、

免疫荧光(in vivo neutrophil

depletion, Immunofluorescence)

Edelson, B. T., et al. (2011). ‘CD8alpha(+) dendritic cells are an obligate

cellular entry point for productive infection by Listeria monocytogenes’

Immunity 35(2): 236-248.

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