Rabbit anti-Prolactin/PRL Recombinant Monoclonal Antibody(235-13)

发表于2024年12月19日由上海金畔生物科技有限公司

Rabbit anti-Prolactin/PRL Recombinant Monoclonal Antibody(235-13)宿主反应种属应用免疫原形式浓度纯化方法类型克隆号储存/保存方法存储溶液背景说明细胞定位UniProt

概述
宿主	Rabbit
反应种属	Human
应用	IHC-P: 1:1000
免疫原	Recombinant protein
性能
形式	Liquid
浓度	0.25 mg/ml
纯化方法	Protein A affinity column
类型	Monoclonal Antibody
克隆号	235-13
储存/保存方法	Store at -20℃ for one year.
存储溶液	PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
靶标
背景说明	Prolactin is a hormone that is mainly synthesized and secreted by lactotroph cells in the anterior pituitary gland. Prolactin signalling occurs via a unique transmembrane prolactin receptor (PRL-R). The structure of the PRL-R has now been elucidated and is similar to that of many biologically fundamental receptors of the class 1 haematopoietic cytokine receptor family such as the growth hormone receptor. The PRL-R is expressed in a wide array of tissues, and a growing number of biological processes continue to be attributed to prolactin [PMID: 30899100].
细胞定位	Secreted
UniProt	P01236

实验结果图

Rabbit anti-Prolactin/PRL Recombinant Monoclonal Antibody(235-13)

IHC shows positive staining in paraffin-embedded human pituitary. Anti-Prolactin/PRL antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

Rabbit anti-Prolactin/PRL Recombinant Monoclonal Antibody(235-13)

Negative control: IHC shows negative staining in paraffin-embedded human cerebral cortex. Anti-Prolactin/PRL antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

Rabbit anti-MEK1(S218/222) Polyclonal Antibody

发表于2024年12月17日由上海金畔生物科技有限公司

Rabbit anti-MEK1(S218/222) Polyclonal Antibody描述别名宿主特异性反应种属预测反应种属应用分子量类型同种型储存/保存方法存储溶液研究领域背景说明细胞定位UniProt参考文献

概述
描述	Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
别名	MEK1抗体;Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; MAP2K1; MEK1; PRKMK1
宿主	Rabbit
特异性	This MEK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-234 amino acids from human MEK1.
反应种属	Human
预测反应种属	D, Ha, M, Rb, R, X, C
应用	WB~~1:1000
分子量	Predicted molecular weight: 43kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
性能
类型	Polyclonal Antibody
同种型	Rabbit Ig
储存/保存方法	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
存储溶液	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
研究领域	Developmental Biology;Signal Transduction
靶标
背景说明	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator- activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
细胞定位	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm Nucleus. Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis
UniProt	Q02750
参考文献
参考文献	Zheng, B., et al., Blood 102(3):1019-1027 (2003). Li, S.P., et al., Cancer Res. 63(13):3473-3477 (2003). Zhu, X., et al., J. Neurochem. 86(1):136-142 (2003). Fringer, J., et al., J. Biol. Chem. 278(23):20612-20617 (2003). Witowsky, J.A., et al., J. Biol. Chem. 278(3):1403-1406 (2003).

实验结果图

Rabbit anti-MEK1(S218/222) Polyclonal Antibody

Western blot analysis of lysate from rat C6 cell line, using MEK1 Antibody (S218/222)(Cat. #JP111450). JP111450 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.

Rabbit anti-MEK1(S218/222) Polyclonal Antibody

Western blot analysis of anti-MEK1 Antibody (S218/222) (Cat.#JP111450) in A2058, A375 cell line lysates (35ug/lane). MEK1 (arrow) was detected using the purified Pab.

alpha-Adaptin,Rabbit IgG anti-Mouse/Rat/Human,WB/IP/

发表于2024年12月17日由上海金畔生物科技有限公司

2lpha-Adaptin,Rabbit IgG anti-Mouse/Rat/Human,WB/IP/

产品编号：	sc-10761
产品名称：	alpha-Adaptin,Rabbit IgG anti-Mouse/Rat/Human,WB/IP/
供应商：	Santa
规格：	200ug
目录价：	￥:2980
库存状态：
CAS编号：
应用范围：
种属来源：
相关信息：

保存条件：
说明书地址：	点击查看详细

AT1,Rabbit IgG anti-Mouse/Rat/Human,WB/IP/

发表于2024年12月14日由上海金畔生物科技有限公司

2T1,Rabbit IgG anti-Mouse/Rat/Human,WB/IP/

产品编号：	sc-1173
产品名称：	AT1,Rabbit IgG anti-Mouse/Rat/Human,WB/IP/
供应商：	Santa
规格：	200ug
目录价：	￥:2980
库存状态：
CAS编号：
应用范围：
种属来源：
相关信息：

保存条件：
说明书地址：	点击查看详细

Rabbit anti-SATB1 Monoclonal Antibody(JRMR-252)

发表于2024年12月14日由上海金畔生物科技有限公司

Rabbit anti-SATB1 Monoclonal Antibody(JRMR-252)别名宿主反应种属应用纯化方法类型克隆号同种型储存/保存方法背景说明细胞定位UniProt

概述
别名	SATB1 抗体;DNA-binding protein SATB1; Special AT-rich sequence-binding protein 1
宿主	Rabbit
反应种属	Human, Mouse, Rat
应用	IHC-P:1:200-1:1000; ICC/IF:1:50;
性能
纯化方法	Protein A
类型	Monoclonal Antibody
克隆号	JRMR-252
同种型	IgG
储存/保存方法	储存温度：-20℃，避免反复冻融
靶标
背景说明	至关重要的沉默因子，有助于启动由Xist RNA介导的X灭活，Xist RNA发生在胚胎发生过程中和淋巴瘤中（通过相似性）。在特殊的富含AT的序列（共有SATB1结合序列（CSBS））上与DNA结合，位于核基质或支架相关区域。认为可以识别双链DNA的糖磷酸结构。转录阻遏物通过与DNA的基质附着区（MARs）结合并诱导局部染色质环重塑，以磷酸化和乙酰化状态依赖的方式控制核和病毒基因的表达。充当多种染色质重塑酶（例如MHC-1位点的PML）的停靠位点，并且还通过直接向启动子和增强子募集corepressors（HDAC）或共激活因子（HATs）。
细胞定位	细胞核
UniProt	Q01826

Rabbit anti-PAR1 Recombinant Monoclonal Antibody(293-58)

发表于2024年12月13日由上海金畔生物科技有限公司

Rabbit anti-PAR1 Recombinant Monoclonal Antibody(293-58)别名宿主反应种属应用免疫原形式浓度纯化方法类型克隆号储存/保存方法存储溶液背景说明细胞定位UniProt

概述
别名	Thrombin
宿主	Rabbit
反应种属	Human
应用	WB: 1:1000
免疫原	Recombinant protein
性能
形式	Liquid
浓度	0.5 mg/mL
纯化方法	Protein A affinity column
类型	Monoclonal Antibody
克隆号	293-58
储存/保存方法	Store at -20℃ for one year.
存储溶液	PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
靶标
背景说明	Thrombin is a Na+-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Binding of Na+ is the major driving force behind the procoagulant, prothrombotic and signaling functions of the enzyme, but is dispensable for cleavage of the anticoagulant protein C. The anticoagulant function of thrombin is under the allosteric control of the cofactor thrombomodulin [PMID: 18329094].
细胞定位	Secreted, Extracellular space
UniProt	P00734

实验结果图

Rabbit anti-PAR1 Recombinant Monoclonal Antibody(293-58)

WB result of PAR1 Rabbit mAb Primary antibody: PAR1 Rabbit mAb at 1/1000 dilution Lane 1: HepG2 whole cell lysate 20 µg Secondary antibody: #JP20040 at 1/10000 dilution Predicted MW: 70kDa Observed MW: 75kDa Exposure time: 90s

Rabbit anti-PAR1 Recombinant Monoclonal Antibody(293-58)

WB result of PAR1 Rabbit mAb Primary antibody: PAR1 Rabbit mAb at 1/1000 dilution Lane 1: Human serum lysate 5 µg Secondary antibody: #JP20040 at 1/10000 dilution Predicted MW: 70kDa Observed MW: 80kDa Exposure time: 6s

Rabbit anti-TMEM239 Polyclonal Antibody(N-term)

发表于2024年12月12日由上海金畔生物科技有限公司

Rabbit anti-TMEM239 Polyclonal Antibody(N-term)描述别名宿主特异性反应种属应用分子量类型同种型储存/保存方法研究领域细胞定位UniProt参考文献

概述
描述	Purified Rabbit Polyclonal Antibody (Pab)
别名	TMEM239抗体;Transmembrane protein 239; TMEM239
宿主	Rabbit
特异性	This TMEM239 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 5-38 amino acids from the N-terminal region of human TMEM239.
反应种属	Human
应用	WB~~1:1000
分子量	Predicted molecular weight: 22kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
性能
类型	Polyclonal Antibody
同种型	Rabbit Ig
储存/保存方法	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
研究领域	Crown Antibodies
靶标
细胞定位	Membrane; Multi-pass membrane protein
UniProt	Q8WW34
参考文献
参考文献	Ota T.,et al.Nat. Genet. 36:40-45(2004). Deloukas P.,et al.Nature 414:865-871(2001). Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

实验结果图

Rabbit anti-TMEM239 Polyclonal Antibody(N-term)

Western blot analysis of lysate from human skeletal muscle tissue lysate, using TMEM239 Antibody (N-term)(Cat. #JP104680). JP104680 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.

Rabbit anti-iNOS Monoclonal Antibody(JRMR-203)

发表于2024年12月12日由上海金畔生物科技有限公司

Rabbit anti-iNOS Monoclonal Antibody(JRMR-203)别名宿主反应种属应用纯化方法类型克隆号同种型储存/保存方法背景说明细胞定位UniProt

概述
别名	iNOS 抗体;HEP-NOS; NOS
宿主	Rabbit
反应种属	Human, Mouse
应用	IHC-P:1:50-1:100;
性能
纯化方法	Protein A
类型	Monoclonal Antibody
克隆号	JRMR-203
同种型	IgG
储存/保存方法	储存温度：-20℃，避免反复冻融
靶标
背景说明	诱导型一氧化氮合酶(iNOS)是利用一氧化氮的氧化应激(自由基)，协助巨噬细胞在免疫系统中对抗病原体的一类酶。是一种在体内具有多种功能的信使分子。参与炎症反应，可增强促炎性介质（如IL6和IL8）的合成。
细胞定位	细胞质
UniProt	P29477

YF®647 Goat Anti-Rabbit IgG (H&L)（YF®647羊抗兔二抗）货号: Y6109S/Y6109L 规格: 20 μL/100 μL

发表于2024年12月12日由上海金畔生物科技有限公司

YF^®647 Goat Anti-Rabbit IgG (H&L)（YF^®647羊抗兔二抗）

产品货号: Y6109S/Y6109L

产品规格: 20 μL/100 μL

目录价（元）:78/298

大包装询价

产品概述：
产品参数
Ex/Em：650/665 nm

储存条件
-20℃ 避光保存，有效期见外包装。

储存 buffer
5 mM HEPES 钠溶液 pH 7.5，75 mM NaCl，1 mg/mL BSA，0.01% PC 300，50%甘油。

产品介绍
YF^®647 Goat Anti-Rabbit IgG (H&L)用于免疫荧光染色。抗体为亲和纯化级羊抗兔 IgG，与兔 IgG 免疫反应性良好；与人 IgG、鼠 IgG 等无交叉反应。YF^®染料为我司自主研发的新一代荧光探针，具有荧光亮度高，光稳定性好，背景低等优点。

使用方法
YF^®647 Goat Anti-Rabbit IgG (H&L)用于免疫荧光时的推荐浓度范围为 1: 100-1: 1000，可根据抗原以及抗体的具体情况进行调整。

注意事项
1. 荧光染料均存在淬灭问题，请尽量注意避光，以减缓荧光淬灭。
2. 为避免反复冻融，可对本产品进行小量分装。
说明书：

YF®647 Goat Anti-Rabbit IgG (H&L)（YF®647羊抗兔二抗）货号: Y6109S/Y6109L 规格: 20 μL/100 μL UE-Y6109S/Y6109L

Rabbit anti-CD155 Recombinant Monoclonal Antibody(289-68)

发表于2024年12月11日由上海金畔生物科技有限公司

Rabbit anti-CD155 Recombinant Monoclonal Antibody(289-68)别名宿主反应种属应用免疫原形式浓度纯化方法类型克隆号储存/保存方法存储溶液背景说明细胞定位UniProt

概述
别名	PVR; Poliovirus receptor; Nectin-like protein 5; NECL-5; PVS
宿主	Rabbit
反应种属	Human
应用	WB: 1:1000, IHC-P: 1:1000-1:2000
免疫原	Recombinant protein
性能
形式	Liquid
浓度	0.25 mg/ml
纯化方法	Protein A affinity column
类型	Monoclonal Antibody
克隆号	289-68
储存/保存方法	Store at -20℃ for one year.
存储溶液	PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
靶标
背景说明	Poliovirus receptor (PVR, CD155), a member of the nectin-like family of proteins, is recently emerging as a promising target in immunotherapy that enhances the existing anti-tumor responses. Similar to other members of the family, PVR is involved in important cellular processes, such as adhesion, contact inhibition, migration, proliferation, and the immune response [PMID: 18648374]. PVR is dramatically overexpressed in several human malignancies, whereas its expression is low or JPent in most healthy tissues [PMID: 10841575, PMID: 11454801, PMID: 15604290, PMID: 15536144, PMID: 19801517]. Consistent with PVR biology, its overexpression promotes tumor cell invasion, migration, and proliferation and is associated with a poor prognosis and enhanced tumor progression [PMID: 16322240, PMID: 17893876, PMID: 25743219, PMID: 25862891]. Simultaneously, PVR has a considerable immu noregulatory potential. It interacts with the (co)stimulatory receptor DNAM-1 and the inhibitory receptors TIGIT and CD96, resulting in either immune cell activation or inhibition, respec tively [PMID: 28870470].
细胞定位	Cell membrane, Secreted
UniProt	P15151

实验结果图