开学季——Atlas Antibodies Pan-Cancer标志物抗体特价促销

开学季——Atlas Antibodies Pan-Cancer标志物抗体特价促销

开学季——Atlas Antibodies Pan-Cancer标志物抗体特价促销

活动时间:2024.3.1-2024.8.27

活动内容:活动期间内,凡订购Atlas Antibodies 品牌指定抗体产品:Pan-Cancer Markers相关研究抗体,可享6折优惠。

活动代码:Atlas2024

活动详细产品清单:

                 product_number                  

              gene_name             

               Clonality              

              Application             

AMAb90501

SOX11

Monoclonal

IHC WB ICC

AMAb90502

SOX11

Monoclonal

IHC WB

AMAb90516

VIM

Monoclonal

IHC WB

AMAb90518

PTPRC

Monoclonal

IHC WB

AMAb90519

PTPRC

Monoclonal

IHC WB

AMAb90523

TG

Monoclonal

IHC WB

AMAb90525

CHGA

Monoclonal

IHC WB ICC

AMAb90558

ANXA1

Monoclonal

IHC WB ICC

AMAb90578

IDH1

Monoclonal

IHC WB ICC

AMAb90627

HER2

Monoclonal

IHC WB

AMAb90628

HER2

Monoclonal

IHC WB ICC

AMAb90635

SATB2

Monoclonal

IHC WB

AMAb90678

SATB2

Monoclonal

IHC WB

AMAb90680

SATB2

Monoclonal

IHC WB

AMAb90754

CD4

Monoclonal

IHC WB

AMAb90776

STAT3

Monoclonal

IHC WB

AMAb90777

STAT3

Monoclonal

IHC WB ICC

AMAb90781

HDAC1

Monoclonal

IHC WB ICC

AMAb90804

MMP9

Monoclonal

IHC WB

AMAb90805

MMP9

Monoclonal

IHC WB

AMAb90806

MMP9

Monoclonal

IHC

AMAb90816

EGFR

Monoclonal

IHC WB

AMAb90819

EGFR

Monoclonal

WB

AMAb90834

AKT1

Monoclonal

WB ICC

AMAb90835

AKT1

Monoclonal

WB

AMAb90844

THY1

Monoclonal

IHC WB

AMAb90846

THY1

Monoclonal

IHC WB

AMAb90859

MCL1

Monoclonal

IHC WB ICC

AMAb90862

CDH1

Monoclonal

IHC WB ICC

AMAb90863

CDH1

Monoclonal

IHC WB

AMAb90865

CDH1

Monoclonal

IHC WB ICC

AMAb90867

ESR1

Monoclonal

IHC WB ICC

AMAb90870

MKI67

Monoclonal

IHC ICC

AMAb90871

ERCC1

Monoclonal

IHC ICC

AMAb90872

ERCC1

Monoclonal

IHC WB

AMAb90873

CD68

Monoclonal

IHC

AMAb90874

CD68

Monoclonal

IHC WB

AMAb90876

CD3E

Monoclonal

IHC WB

AMAb90883

CD8A

Monoclonal

IHC

AMAb90898

CD14

Monoclonal

IHC

AMAb90900

KIT

Monoclonal

WB

AMAb90901

KIT

Monoclonal

IHC WB

AMAb90904

KIT

Monoclonal

IHC WB

AMAb90925

ENG

Monoclonal

IHC

AMAb90928

VWF

Monoclonal

IHC WB

AMAb90931

VWF

Monoclonal

IHC WB

AMAb90956

TP53

Monoclonal

IHC WB ICC

AMAb90959

PARP1

Monoclonal

IHC WB ICC

AMAb90960

PARP1

Monoclonal

IHC WB

AMAb90975

EZR

Monoclonal

IHC WB ICC

AMAb90976

EZR

Monoclonal

IHC WB ICC

AMAb90977

EZR

Monoclonal

IHC WB ICC

AMAb90979

EZR

Monoclonal

IHC WB ICC

AMAb91019

HSP90B1

Monoclonal

IHC WB ICC

AMAb91038

S100B

Monoclonal

IHC WB

AMAb91056

MUC16

Monoclonal

IHC ICC

AMAb91057

MUC16

Monoclonal

IHC

AMAb91197

PDCD1

Monoclonal

IHC WB

AMAb91209

CTNNB1

Monoclonal

IHC WB ICC

AMAb91210

CTNNB1

Monoclonal

IHC WB ICC

AMAb91220

CDH2

Monoclonal

IHC WB ICC

AMAb91223

FN1

Monoclonal

IHC WB

AMAb91224

TP63

Monoclonal

IHC WB

AMAb91257

BRAF

Monoclonal

IHC WB

AMAb91258

BRAF

Monoclonal

IHC WB

AMAb91297

SOX10

Monoclonal

IHC ICC

AMAb91302

DES

Monoclonal

WB ICC

AMAb91329

PRAME

Monoclonal

WB ICC

AMAb91330

PRAME

Monoclonal

IHC WB

AMAb91366

CTGF

Monoclonal

IHC WB

AMAb91411

EPCAM

Monoclonal

IHC WB

AMAb91413

EPCAM

Monoclonal

IHC WB

AMAb91447

ITGA5

Monoclonal

IHC WB

AMAb91448

ITGA5

Monoclonal

IHC

AMAb91449

ITGA5

Monoclonal

IHC WB

AMAb91450

ITGA6

Monoclonal

IHC

AMAb91469

ITGA2

Monoclonal

IHC WB

AMAb91488

PAX8

Monoclonal

IHC WB ICC

AMAb91490

BAX

Monoclonal

IHC WB

AMAb91492

BCL2

Monoclonal

IHC WB

AMAb91494

PROM1

Monoclonal

IHC WB

AMAb91497

CDK2

Monoclonal

IHC WB ICC

AMAb91499

CDK4

Monoclonal

IHC WB ICC

AMAb91508

MTOR

Monoclonal

WB

AMAb91513

PIK3CA

Monoclonal

WB

AMAb91514

PIK3CA

Monoclonal

IHC

AMAb91515

PLK1

Monoclonal

WB

AMAb91520

SMAD2

Monoclonal

IHC WB ICC

AMAb91525

GATA3

Monoclonal

IHC WB ICC

AMAb91529

PGR

Monoclonal

IHC ICC

AMAb91531

KRT7

Monoclonal

IHC WB

AMAb91533

MUC1

Monoclonal

IHC

AMAb91547

AR

Monoclonal

IHC WB

AMAb91549

KRT5

Monoclonal

IHC WB ICC

AMAb91564

KRT20

Monoclonal

IHC

AMAb91567

KLK3

Monoclonal

IHC WB

AMAb91569

KLK3

Monoclonal

IHC WB

AMAb91570

CHEK2

Monoclonal

IHC WB ICC

AMAb91587

JUN

Monoclonal

IHC ICC

AMAb91594

SMAD4

Monoclonal

IHC WB

AMAb91610

AFP

Monoclonal

IHC WB

AMAb91611

AFP

Monoclonal

IHC WB

AMAb91646

CD163

Monoclonal

IHC WB

AMAb91648

CD163

Monoclonal

IHC

AMAb91698

ITGA4

Monoclonal

WB

AMAb91699

ITGA4

Monoclonal

WB

AMAb91716

TCF7L2

Monoclonal

IHC WB

AMAb91718

CSF1R

Monoclonal

ICC

AMAb91719

HMOX1

Monoclonal

IHC

AMAb91721

HMOX1

Monoclonal

IHC

AMAb91735

PTEN

Monoclonal

IHC WB

AMAb91736

PTEN

Monoclonal

IHC WB

AMAb91749

EZH2

Monoclonal

IHC WB ICC

AMAb91750

EZH2

Monoclonal

IHC ICC

AMAb91752

EZH2

Monoclonal

IHC WB ICC

AMAb91761

BIRC5

Monoclonal

WB

AMAb91768

SALL4

Monoclonal

IHC WB ICC

AMAb91769

SALL4

Monoclonal

IHC WB ICC

AMAb91770

SALL4

Monoclonal

ICC

AMAb91779

CCND1

Monoclonal

ICC

AMAb91780

CCND1

Monoclonal

ICC

AMAb91782

CD5

Monoclonal

IHC WB ICC

AMAb91783

CD5

Monoclonal

IHC WB ICC

AMAb91784

FCER2

Monoclonal

IHC

AMAb91788

MME

Monoclonal

IHC

AMAb91800

TNFRSF8

Monoclonal

IHC

AMAb91803

GPC3

Monoclonal

IHC

AMAb91807

NCAM1

Monoclonal

IHC

AMAb91812

CALB2

Monoclonal

IHC WB

AMAb91813

CALB2

Monoclonal

IHC

AMAb91814

CALB2

Monoclonal

IHC WB

AMAb91815

MCAM

Monoclonal

IHC

AMAb91816

MLANA

Monoclonal

IHC WB ICC

AMAb91817

MLANA

Monoclonal

IHC WB ICC

AMAb91818

MLANA

Monoclonal

IHC WB ICC

AMAb91823

CD99

Monoclonal

IHC

AMAb91825

NAPSA

Monoclonal

IHC

AMAb91827

CDX2

Monoclonal

IHC WB ICC

AMAb91828

CDX2

Monoclonal

IHC WB ICC

AMAb91832

CDKN1A

Monoclonal

WB ICC

AMAb91839

WT1

Monoclonal

IHC WB ICC

AMAb91840

WT1

Monoclonal

IHC WB ICC

AMAb91842

WT1

Monoclonal

IHC WB ICC

AMAb91844

FOXO1

Monoclonal

WB

AMAb91845

CD44

Monoclonal

IHC WB

AMAb91846

CD44

Monoclonal

IHC WB

AMAb91847

CD44

Monoclonal

IHC WB

AMAb91848

CD44

Monoclonal

IHC WB

AMAb91858

IL33

Monoclonal

IHC ICC

AMAb91872

FOXO3

Monoclonal

IHC WB

AMAb91874

FOXO3

Monoclonal

IHC

AMAb91878

YAP1

Monoclonal

IHC

AMAb91891

MSH2

Monoclonal

IHC WB ICC

AMAb91892

MSH2

Monoclonal

IHC WB ICC

AMAb91894

MSH2

Monoclonal

IHC WB ICC

AMAb91903

MSH6

Monoclonal

IHC WB

HPA000440

PTPRC

Polyclonal

IHC

HPA000449

ESR1

Polyclonal

IHC WB ICC

HPA000722

BID

Polyclonal

IHC WB ICC

HPA000907

HIF1A

Polyclonal

ICC

HPA000927

SERPINA1

Polyclonal

IHC WB ICC

HPA001169

COMT

Polyclonal

WB

HPA001200

EGFR

Polyclonal

IHC WB

HPA001238

MMP9

Polyclonal

IHC ICC

HPA001249

IKBKB

Polyclonal

IHC WB ICC

HPA001338

ERBB2

Polyclonal

ICC

HPA001383

ERBB2

Polyclonal

IHC WB ICC

HPA001466

PTPN6

Polyclonal

IHC WB ICC

HPA001605

KRT18

Polyclonal

IHC WB ICC

HPA001610

PON1

Polyclonal

IHC WB

HPA001641

RBP4

Polyclonal

IHC

HPA001815

VWF

Polyclonal

IHC

HPA001878

CHEK2

Polyclonal

IHC WB ICC

HPA002082

VWF

Polyclonal

IHC WB

HPA002127

CD14

Polyclonal

IHC WB

HPA002190

CD55

Polyclonal

IHC

HPA002465

KRT19

Polyclonal

IHC ICC

HPA002636

AURKA

Polyclonal

IHC WB ICC

HPA002655

SELP

Polyclonal

IHC WB

HPA002695

LCN2

Polyclonal

IHC WB

HPA003134

ZAP70

Polyclonal

IHC WB

HPA003494

LCK

Polyclonal

IHC WB ICC

HPA004179

MUC1

Polyclonal

IHC

HPA004182

LRP1

Polyclonal

IHC ICC

HPA004471

KIT

Polyclonal

IHC

HPA004690

PECAM1

Polyclonal

IHC

HPA004751

PGR

Polyclonal

IHC

HPA004877

ICAM1

Polyclonal

IHC WB

HPA005688

CASP8

Polyclonal

IHC WB

HPA005990

SELP

Polyclonal

IHC WB

HPA006185

SDC1

Polyclonal

IHC ICC

HPA006288

TP63

Polyclonal

IHC WB

HPA006458

TOP2A

Polyclonal

IHC WB

HPA007010

TP63

Polyclonal

IHC ICC

HPA007234

CD81

Polyclonal

IHC ICC

HPA007235

MUC1

Polyclonal

IHC

HPA008356

RET

Polyclonal

IHC ICC

HPA008428

PGR

Polyclonal

IHC

HPA008848

MCAM

Polyclonal

IHC WB

HPA008855

MUC1

Polyclonal

IHC

HPA008877

ITGB2

Polyclonal

IHC WB

HPA010088

CD63

Polyclonal

IHC

HPA010607

AFP

Polyclonal

IHC WB

HPA010694

ALK

Polyclonal

IHC ICC

HPA010738

ADAM17

Polyclonal

IHC ICC

HPA011272

ANXA1

Polyclonal

IHC WB ICC

HPA011727

HDAC2

Polyclonal

IHC WB ICC

HPA011862

ENG

Polyclonal

IHC WB

HPA013349

APC

Polyclonal

IHC

HPA014341

MS4A1

Polyclonal

IHC WB ICC

HPA014391

MS4A1

Polyclonal

IHC WB

HPA016894

ITGB2

Polyclonal

IHC WB ICC

HPA017284

TARDBP

Polyclonal

IHC WB ICC

HPA019154

SMAD4

Polyclonal

IHC WB ICC

HPA019163

CCL2

Polyclonal

IHC ICC

HPA019805

TRAF6

Polyclonal

IHC WB ICC

HPA020599

TRAF6

Polyclonal

IHC

HPA021019

TGM2

Polyclonal

IHC WB

HPA022903

LRP1

Polyclonal

IHC WB

HPA023600

AFP

Polyclonal

IHC WB

HPA026321

HDAC6

Polyclonal

IHC ICC

HPA027066

FN1

Polyclonal

IHC WB

HPA027444

FAS

Polyclonal

IHC WB ICC

HPA027582

ITGA6

Polyclonal

IHC

HPA027802

CCND1

Polyclonal

ICC

HPA027852

ITGB3

Polyclonal

IHC

HPA027878

BAX

Polyclonal

IHC WB

HPA028185

BAD

Polyclonal

IHC ICC

HPA028409

ABL1

Polyclonal

IHC ICC

HPA029160

CTNNB1

Polyclonal

IHC ICC

HPA029207

NFKBIA

Polyclonal

IHC WB ICC

HPA029298

ACE

Polyclonal

IHC WB

HPA029518

TGM2

Polyclonal

IHC WB ICC

HPA029693

HDAC1

Polyclonal

IHC WB ICC

HPA029735

E2F1

Polyclonal

WB ICC

HPA030471

BMI1

Polyclonal

ICC

HPA030522

PCNA

Polyclonal

IHC WB ICC

HPA030741

CCNB1

Polyclonal

WB ICC

HPA030875

SRC

Polyclonal

WB ICC

HPA031053

PROM1

Polyclonal

IHC WB

HPA031169

ITGA2B

Polyclonal

IHC

HPA031170

ITGA2B

Polyclonal

IHC WB

HPA031171

ITGA2B

Polyclonal

IHC

HPA031200

EPAS1

Polyclonal

ICC

HPA031335

PTEN

Polyclonal

WB ICC

HPA031567

CD40

Polyclonal

IHC

HPA035097

GJA1

Polyclonal

IHC

HPA036722

CD34

Polyclonal

IHC

HPA036723

CD34

Polyclonal

IHC ICC

HPA037422

AXL

Polyclonal

IHC WB

HPA037708

AURKB

Polyclonal

ICC

HPA037756

CD8A

Polyclonal

IHC

HPA040067

GAPDH

Polyclonal

IHC WB ICC

HPA040957

CD3E

Polyclonal

IHC WB

HPA042754

PRNP

Polyclonal

IHC

HPA043416

CD5

Polyclonal

IHC

HPA043955

CD3E

Polyclonal

IHC WB

HPA044364

CHEK1

Polyclonal

ICC

HPA045396

ERBB3

Polyclonal

IHC WB

HPA045669

CDX2

Polyclonal

ICC

HPA045725

SOX2

Polyclonal

WB ICC

HPA045943

FOXP3

Polyclonal

WB ICC

HPA046386

SMAD3

Polyclonal

ICC

HPA046404

CD163

Polyclonal

IHC

HPA046488

CASP9

Polyclonal

IHC

HPA047838

CDKN2A

Polyclonal

ICC

HPA048540

PTH

Polyclonal

IHC

HPA049174

TLR4

Polyclonal

IHC

HPA049580

CDX2

Polyclonal

ICC

HPA049866

KRT8

Polyclonal

IHC WB ICC

HPA050039

SERPINE1

Polyclonal

IHC ICC

HPA050092

CD80

Polyclonal

IHC

HPA050843

PLAUR

Polyclonal

IHC

HPA051065

ALDH2

Polyclonal

IHC WB

HPA051244

TP53

Polyclonal

WB ICC

HPA051575

ADAM17

Polyclonal

WB ICC

HPA051638

PLK1

Polyclonal

IHC

HPA051974

CD163

Polyclonal

IHC

HPA052474

MAP1LC3A

Polyclonal

IHC

HPA052504

HSPA1A

Polyclonal

IHC WB ICC

HPA052583

MME

Polyclonal

IHC

HPA052707

MLH1

Polyclonal

IHC ICC

HPA053417

TIMP1

Polyclonal

IHC

HPA053848

WT1

Polyclonal

ICC

HPA054622

IL2RA

Polyclonal

IHC

HPA055295

BCL2

Polyclonal

ICC

HPA055431

FCGR3A

Polyclonal

IHC

HPA055607

MET

Polyclonal

ICC

HPA056072

MME

Polyclonal

IHC

HPA057936

IDH1

Polyclonal

IHC WB

HPA059474

JUN

Polyclonal

ICC

HPA060714

MLH1

Polyclonal

ICC

HPA060839

CD5

Polyclonal

IHC

HPA060991

ITGA2

Polyclonal

IHC

HPA061280

GAPDH

Polyclonal

WB ICC

HPA063104

FOXO3

Polyclonal

ICC

HPA063532

TP53

Polyclonal

ICC

HPA063556

ITGA2

Polyclonal

IHC WB

HPA063909

MMP9

Polyclonal

IHC WB

HPA064453

CALCA

Polyclonal

IHC WB

HPA064535

CDK5

Polyclonal

IHC ICC

HPA067168

NOTCH1

Polyclonal

ICC

HPA067203

SMAD3

Polyclonal

IHC WB

HPA067477

SDC1

Polyclonal

IHC WB

HPA069003

ITGB1

Polyclonal

IHC

HPA069116

VEGFA

Polyclonal

IHC

HPA069867

VCAM1

Polyclonal

WB ICC

HPA070003

CD28

Polyclonal

IHC

HPA071048

BRAF

Polyclonal

WB ICC

HPA073252

KIT

Polyclonal

ICC

活动说明:

1. 所有定制类产品和已申请特价的产品不参加本次活动。

2. 本优惠内容仅限中国客户使用,并且不与其他活动叠加生效。

3. 上述活动如遇不可抗力因素,因故无法进行时,上海金畔生物保留更换、修改或停止活动之权利。

 

Pan-Cancer, 又称泛癌,其并不是特指某种肿瘤。通过泛癌分析,研究者可以发现不同肿瘤类型中的基因组和细胞改变之间的相似性和差异,检测与肿瘤发生有关的共同途径等,有助于科学家寻找到某些疾病发生发展的普遍规律。

 

Atlas Antibodies公司成立于2006年,由著名的人类蛋白质图谱项目(Human Protein Atlas)的研究人员创建,公司宗旨在为所有科研工作者提供针对整个人类蛋白质图谱的高品质抗体。目前,可提供超过22000种类的一抗,覆盖整个人类蛋白质图谱。 其中,对于此次促销内容的Pan-Cancer Marker Antibodies, 他们可提供300多种相关标记物抗体,这些抗体均在多种人类癌症组织(约20种)和细胞上进行了相关实验验证,均获得了高特异性的染色结果(结果数据可在Human Protein Atlas portal网站上查询)。这些抗体靶标覆盖范围全面,验证实验类型全面,染色结果可靠。欢迎大家选购。另外, 更有Atlas Antibodies厂家提供的Pan-Cancer Markers白皮书,其中详细介绍了Pan-Cancer Markers的相关知识以及其在蛋白质组表达分析中的作用和研究现状。大家有需要,可以联系我们索取。


Pan-Cancer Marker热销产品:

产品货号 产品名称 实验应用 相关癌症
AMAb90578 Anti-IDH1 IHCWBICC 胶质瘤(多形性胶质母胶质瘤)
AMAb90628 Anti-HER2 IHCWBICC 乳腺癌,卵巢癌,胃癌
HPA001200 Anti-EGFR IHCWB 肺癌、结直肠癌、
胶质母细胞瘤
AMAb91735 Anti-PTEN IHCWB 乳腺癌、前列腺癌、
子宫内膜癌
AMAb91513 Anti-PIK3CA WB 乳腺癌、结肠直肠癌、
AMAb91514 IHC 卵巢癌

 

Pan-Cancer热门标志物抗体染色结果示例:

开学季——Atlas Antibodies Pan-Cancer标志物抗体特价促销

开学季——Atlas Antibodies Pan-Cancer标志物抗体特价促销


Atlas Antibodies产品独特之处:

覆盖整个人类蛋白质图谱的2,2000多种一抗;

每种抗体均有超过700多张的IHC/WB/IF图片;

专注于免疫组化实验功能验证,高品质,高特异性。


Atlas Antibodies可以提供的产品类型:    

开学季——Atlas Antibodies Pan-Cancer标志物抗体特价促销 开学季——Atlas Antibodies Pan-Cancer标志物抗体特价促销 开学季——Atlas Antibodies Pan-Cancer标志物抗体特价促销
PrecisA重组单克隆抗体 TripleA多克隆抗体 对照抗原

                        

Atlas Antibodies抗体验证策略:

开学季——Atlas Antibodies Pan-Cancer标志物抗体特价促销

 

更多Atlas Antibodies信息请登录 https://www.atlasantibodies.com/ 

详情请联系Atlas Antibodies一级代理商-上海金畔生物

Capivasertib

Capivasertib

货号:
IC2330

品牌:
Jinpan

Capivasertib

暂无详情

Capivasertib

暂无详情
产品简介
有效期 2年
描述 是一种有效的 pan-AKT 激酶抑制剂,抑制 Akt1,Akt2 和 Akt3。
MDL MFCD22628785
别名 AZD-5363
CAS 1143532-39-1
分子式 C21H25ClN6O2
分子量 428.92
储存条件 RT
纯度 ≥98%
外观(性状) White to off white Powder
单位
生物活性 Capivasertib (AZD5363) 是一种有效的 pan-AKT 激酶抑制剂,抑制 Akt1,Akt2 和 Akt3,IC50 分别为 3,7 和 7 nM。[1]
In Vivo 将Capivasertib(AZD5363)口服给予裸鼠导致BT474c异种移植物中PRAS40,GSK3β和S6磷酸化的剂量和时间依赖性降低(PRAS40磷酸化EC50~0.1μM总血浆暴露),血糖浓度的可逆增加和剂量U87-MG异种移植物中2 [18 F]氟-2-脱氧-D-葡萄糖(18 F-FDG)摄取的依赖性降低。 Capivasertib的慢性口服给药引起源自各种肿瘤类型的异种移植物的剂量依赖性生长抑制,所述肿瘤类型包括对曲妥珠单抗具有抗性的HER2 +乳腺癌模型。 Capivasertib还显著增强多西紫杉醇,拉帕替尼和曲妥珠单抗在乳腺癌异种移植物中的抗肿瘤活性[1]。
SMILES O=C(C1(N)CCN(C2=C3C(NC=C3)=NC=N2)CC1)N[C@H](C4=CC=C(Cl)C=C4)CCO
靶点 Akt
动物实验 小鼠[1]使用特异性,无病原体的雌性裸鼠(nu / nu:Alpk)和雄性SCID小鼠(SCID / CB17; 786-0异种移植物研究)。当平均肿瘤大小达到约0.2cm 3时,将小鼠随机分为对照组和治疗组。治疗组接受通过口服强饲法溶解于10%DMSO 25%w / v Kleptose HPB(Roquette)缓冲液中的Capivasertib(AZD5363)的不同剂量方案,在第1天通过静脉内注射将多西紫杉醇溶于2.6%乙醇的可注射水中。每周一次15或5毫克/千克。当组合施用时,在口服剂量的Capivasertib(AZD5363)之前1小时施用多西紫杉醇。对照组单独接受DMSO / Kleptose缓冲液,每天两次通过口服强饲法。在研究期间每周两次记录肿瘤体积(通过厚度测量),动物体重和肿瘤状况。通过CO 2安乐死处死小鼠。使用下式计算肿瘤体积(使长度为肿瘤的最长直径,宽度为相应的垂直直径):(长×宽)×√(长×宽)×(π/ 6)。通过比较对照组和治疗组之间肿瘤体积的差异来评估治疗开始时的生长抑制。
细胞实验 细胞增殖测定通过MTS和Sytox Green两种方法测定。简而言之,将细胞接种在96孔板中(密度允许在72小时测定期间进行对数生长)并在37℃,5%CO 2下孵育过夜。然后将细胞暴露于30至0.003μM的Capivasertib浓度72小时。对于MTS终点,通过CellTiter AQueous Non-Radioactive Cell Proliferation Assay试剂测量细胞增殖。使用Tecan Ultra仪器测量吸光度。对于Sytox Green终点,将在TBS-EDTA缓冲液中稀释的Sytox Green核酸染料加入细胞(终浓度为0.13μM),并使用Acumen Explorer检测死细胞数。然后通过加入皂苷(0.03%终浓度,在TBS-EDTA缓冲液中稀释)使细胞透化,孵育过夜并测量总细胞计数。对MTS和Sytox Green终点进行预测量测量,并且使用吸光度读数(MTS)或活细胞计数[1]确定将处理细胞的生长减少至未处理细胞(GI50)值的一半所需的浓度。
数据来源文献 [1]. Davies BR, et al. Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol Cancer Ther. 2012 Apr;11(4):873-87
规格 5mg