Trilink CleanCap® Reagent AG (3′ OMe) – (N-7413)产品介绍
CleanCap AG (3’OMe)用于mRNA的共转录，m7(3’OMeG)(5′)ppp(5′)(2’OMeA)pG
产品描述：
CleanCap®AG (3′ OMe)是TriLink公司的专有的共转录加帽试剂，用于5 ‘帽端mRNA转录，形成Cap 1结构。CleanCap的加帽效率高达98%。Trilink N-7413TrilinkCleanCap®Reagent AG共转录产品的cap1mRNA要比 mCAP和ARCA加帽产生的cap0 mRNA活性更好。
产品信息：
| 产品货号 | N-7413 |
| 纯度 | ≥95% by AX-HPLC |
| 消光系数 | 30,539 Lmol-1cm-1 at 255 nm |
| 分子式 | C33H45N15O24P4 (游离酸) |
| 分子质量 | 1159.6 |
| 盐形式 | Na+ |
| 浓度 | 100 mM |
| 溶液组分 | 水 |
| 推荐的储存温度 | -20°C 或者以下 |
| 其他名称 | CleanCap® Reagent AG(3′ OMe) for co-transcriptional capping of mRNA, m7(3’OMeG)(5’)ppp(5′)(2’OMeA)pG |
| 应用 | CRISPR, In vitro Transcription, Recombinases, TALENS, Transposases, Vaccine Development, Zinc Finger Nucleases |
| 主链 | 5′-5′-三磷酸 |
| 碱基类似物 | 腺苷酸，鸟苷酸 |
| 核苷酸种类 | 帽类似物 |
产品规格如下：
| 供应商 | 产品编号 | 产品名称 | 规格 |
| TriLink | N-7413-1 | CleanCap Reagent AG（3’OMe）, 1 umole | 1 umol |
| TriLink | N-7413-5 | CleanCap Reagent AG（3’OMe）, 5 umole | 5 umol |
| TriLink | N-7413-10 | CleanCap Reagent AG（3’OMe）, 10 umole | 10 umol |
| TriLink | N-7413-100 | CleanCap Reagent AG（3’OMe）, 100 umole | 100 umol |
文献引用；
● Rothgangl, T;Dennis, MK;Lin, PJC;Oka, R;Witzigmann, D;Villiger, L;Qi, W;Hruzova, M;Kissling, L;Lenggenhager, D;Borrelli, C;Egli, S;Frey, N;Bakker, N;Walker, JA;Kadina, AP;Victorov, DV;Pacesa, M;Kreutzer, S;Kontarakis, Z;Moor, A;Jinek, M;Weissman, D;Stoffel, M;van Boxtel, R;Holden, K;Pardi, N;Th . In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels
● Weissman, D;Alameh, MG;de Silva, T;Collini, P;Hornsby, H;Brown, R;LaBranche, CC;Edwards, RJ;Sutherland, L;Santra, S;Mansouri, K;Gobeil, S;McDanal, C;Pardi, N;Hengartner, N;Lin, PJC;Tam, Y;Shaw, PA;Lewis, MG;Boesler, C;?ahin, U;Acharya, P;Haynes, BF;Korber, B;Montefiori, DC; . D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization
● Pandey, RR;Delfino, E;Homolka, D;Roithova, A;Chen, KM;Li, L;Franco, G;V . The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues
● Mu, Z;Wiehe, K;Saunders, KO;Henderson, R;Cain, DW;Parks, R;Martik, D;Mansouri, K;Edwards, RJ;Newman, A;Lu, X;Xia, SM;Bonsignori, M;Montefiori, D;Han, Q;Venkatayogi, S;Evangelous, T;Wang, Y;Rountree, W;Tam, Y;Barbosa, C;Munir Alam, S;Williams, WB;Pardi, N;Weissman, D;Haynes, BF; . Ability of nucleoside-modified mRNA to encode HIV-1 envelope trimer nanoparticles
● Martinez, DR;Schaefer, A;Leist, SR;De la Cruz, G;West, A;Atochina-Vasserman, EN;Parks, R;Barr, M;Li, D;Yount, B;Saunders, KO;Weissman, D;Haynes, BF;Montgomery, SA;Baric, RS; . Chimeric spike mRNA vaccines protect against sarbecovirus challenge in mice
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