Mouse Monoclonal Antibody (Mab)

NOTCH3抗体;Neurogenic locus notch homolog protein 3; Notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; NOTCH3

Mouse

This NOTCH3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 2291-2321 amino acids from the C-terminal region of human NOTCH3.

Human

WB~~1:100~250

Predicted molecular weight: 244kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Monoclonal Antibody

487CT6.9.2

IgG1

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Cardiovascular;Neuroscience;Signal Transduction

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).

Cell membrane; Single-pass type I membrane protein

Q9UM47

Liu, H., et al. Circ. Res. 107(7):860-870(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Menon, S., et al. Cephalalgia (2010) In press :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :