清道夫受体B2抗体(Scavenger Receptor B2/CD36 Monoclonal Antibody) Item No. 10009893

清道夫受体B2抗体(Scavenger Receptor B2/CD36 Monoclonal Antibody) Item No. 10009893

本文是对Cayman热销产品清道夫受体B2抗体(Scavenger Receptor B2/CD36 Monoclonal Antibody)的产品简单介绍,该产品货号为10009893,如需购买或咨询该产品其它详情,请联系Cayman代理商上海金畔生物。


别名:GPIIIb

   GPIV

   Platelet Glycoprotein 4

   Fatty Acid Translocase

   PAS IV

   Platelet Collagen Receptor

   Thrombospondin Receptor

免疫原:Recombinant full-length mouse CD36 expressed in adenovirus

克隆号:JC63.1

缓冲液:PBS, pH 7.2

宿主:CD36 null mouse

亚型:IgA

应用:FC, ICC

 

产品介绍

 

CD36也被称为清道夫受体B2或脂肪酸转位酶,是一种跨膜糖蛋白,在脂肪酸摄取、脂质代谢和信号转导中发挥作用。它由N和C端胞质尾区,两个跨膜域和一个细胞外循环,与多种脂质结合,包括长链脂肪酸,氧化低密度脂蛋白和氧化磷脂和蛋白质配体。多种细胞可表达CD36,包括血小板、单核细胞、巨噬细胞等造血细胞,以及脂肪细胞、肠细胞、心肌和骨骼肌细胞、内皮细胞和上皮细胞。


CD36的表达受多种转录因子调控,包括过氧化物酶体增殖物激活受体(PPAR)、STAT3和HIF-1a,并以一种组织依赖的方式进行调控。Cayman的Scavenger Receptor B2/CD36单克隆抗体(Clone JC63.1)内毒素水平≤2 EU/mg可用于流式细胞术(FC)和免疫细胞(ICC)应用。

 

详细使用说明请见https://cdn.caymanchem.com/cdn/insert/10009893.pdf

 

产品信息

货号

名称

规格

10009893

Scavenger Receptor B2/CD36 Monoclonal Antibody (Clone JC63.1) (Low Endotoxin)

100μg / 500μg

 

详情请咨询 Cayman 中国代理-上海金畔生物科技

Rabbit anti-SATB1 Monoclonal Antibody(JRMR-252)

Rabbit anti-SATB1 Monoclonal Antibody(JRMR-252)别名宿主反应种属应用纯化方法类型克隆号同种型储存/保存方法背景说明细胞定位UniProt

概述
别名
SATB1 抗体;DNA-binding protein SATB1; Special AT-rich sequence-binding protein 1
宿主
Rabbit
反应种属
Human, Mouse, Rat
应用
IHC-P:1:200-1:1000; ICC/IF:1:50;
性能
纯化方法
Protein A
类型
Monoclonal Antibody
克隆号
JRMR-252
同种型
IgG
储存/保存方法
储存温度:-20℃,避免反复冻融
靶标
背景说明
至关重要的沉默因子,有助于启动由Xist RNA介导的X灭活,Xist RNA发生在胚胎发生过程中和淋巴瘤中(通过相似性)。 在特殊的富含AT的序列(共有SATB1结合序列(CSBS))上与DNA结合,位于核基质或支架相关区域。 认为可以识别双链DNA的糖磷酸结构。 转录阻遏物通过与DNA的基质附着区(MARs)结合并诱导局部染色质环重塑,以磷酸化和乙酰化状态依赖的方式控制核和病毒基因的表达。 充当多种染色质重塑酶(例如MHC-1位点的PML)的停靠位点,并且还通过直接向启动子和增强子募集corepressors(HDAC)或共激活因子(HATs)。
细胞定位
细胞核
UniProt
Q01826

Rabbit anti-PAR1 Recombinant Monoclonal Antibody(293-58)

Rabbit anti-PAR1 Recombinant Monoclonal Antibody(293-58)别名宿主反应种属应用免疫原形式浓度纯化方法类型克隆号储存/保存方法存储溶液背景说明细胞定位UniProt

概述
别名
Thrombin
宿主
Rabbit
反应种属
Human
应用
WB: 1:1000
免疫原
Recombinant protein
性能
形式
Liquid
浓度
0.5 mg/mL
纯化方法
Protein A affinity column
类型
Monoclonal Antibody
克隆号
293-58
储存/保存方法
Store at -20℃ for one year.
存储溶液
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
靶标
背景说明
Thrombin is a Na+-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Binding of Na+ is the major driving force behind the procoagulant, prothrombotic and signaling functions of the enzyme, but is dispensable for cleavage of the anticoagulant protein C. The anticoagulant function of thrombin is under the allosteric control of the cofactor thrombomodulin [PMID: 18329094].
细胞定位
Secreted, Extracellular space
UniProt
P00734

实验结果图

Rabbit anti-PAR1 Recombinant Monoclonal Antibody(293-58)

WB result of PAR1 Rabbit mAb Primary antibody: PAR1 Rabbit mAb at 1/1000 dilution Lane 1: HepG2 whole cell lysate 20 µg Secondary antibody: #JP20040 at 1/10000 dilution Predicted MW: 70kDa Observed MW: 75kDa Exposure time: 90s

Rabbit anti-PAR1 Recombinant Monoclonal Antibody(293-58)

WB result of PAR1 Rabbit mAb Primary antibody: PAR1 Rabbit mAb at 1/1000 dilution Lane 1: Human serum lysate 5 µg Secondary antibody: #JP20040 at 1/10000 dilution Predicted MW: 70kDa Observed MW: 80kDa Exposure time: 6s

Rabbit anti-iNOS Monoclonal Antibody(JRMR-203)

Rabbit anti-iNOS Monoclonal Antibody(JRMR-203)别名宿主反应种属应用纯化方法类型克隆号同种型储存/保存方法背景说明细胞定位UniProt

概述
别名
iNOS 抗体;HEP-NOS; NOS
宿主
Rabbit
反应种属
Human, Mouse
应用
IHC-P:1:50-1:100;
性能
纯化方法
Protein A
类型
Monoclonal Antibody
克隆号
JRMR-203
同种型
IgG
储存/保存方法
储存温度:-20℃,避免反复冻融
靶标
背景说明
诱导型一氧化氮合酶(iNOS)是利用一氧化氮的氧化应激(自由基),协助巨噬细胞在免疫系统中对抗病原体的一类酶。是一种在体内具有多种功能的信使分子。参与炎症反应,可增强促炎性介质(如IL6和IL8)的合成。
细胞定位
细胞质
UniProt
P29477

Rabbit anti-CD155 Recombinant Monoclonal Antibody(289-68)

Rabbit anti-CD155 Recombinant Monoclonal Antibody(289-68)别名宿主反应种属应用免疫原形式浓度纯化方法类型克隆号储存/保存方法存储溶液背景说明细胞定位UniProt

概述
别名
PVR; Poliovirus receptor; Nectin-like protein 5; NECL-5; PVS
宿主
Rabbit
反应种属
Human
应用
WB: 1:1000, IHC-P: 1:1000-1:2000
免疫原
Recombinant protein
性能
形式
Liquid
浓度
0.25 mg/ml
纯化方法
Protein A affinity column
类型
Monoclonal Antibody
克隆号
289-68
储存/保存方法
Store at -20℃ for one year.
存储溶液
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
靶标
背景说明
Poliovirus receptor (PVR, CD155), a member of the nectin-like family of proteins, is recently emerging as a promising target in immunotherapy that enhances the existing anti-tumor responses. Similar to other members of the family, PVR is involved in important cellular processes, such as adhesion, contact inhibition, migration, proliferation, and the immune response [PMID: 18648374]. PVR is dramatically overexpressed in several human malignancies, whereas its expression is low or JPent in most healthy tissues [PMID: 10841575, PMID: 11454801, PMID: 15604290, PMID: 15536144, PMID: 19801517]. Consistent with PVR biology, its overexpression promotes tumor cell invasion, migration, and proliferation and is associated with a poor prognosis and enhanced tumor progression [PMID: 16322240, PMID: 17893876, PMID: 25743219, PMID: 25862891]. Simultaneously, PVR has a considerable immu noregulatory potential. It interacts with the (co)stimulatory receptor DNAM-1 and the inhibitory receptors TIGIT and CD96, resulting in either immune cell activation or inhibition, respec tively [PMID: 28870470].
细胞定位
Cell membrane, Secreted
UniProt
P15151

实验结果图

Rabbit anti-CD155 Recombinant Monoclonal Antibody(289-68)

WB result of CD155 Rabbit mAb Primary antibody: CD155 Rabbit mAb at 1/1000 dilution Lane 1: Raji whole cell lysate 20ug Lane 2: HUVEC whole cell lysate 20ug Lane 3: HeLa whole cell lysate 20ug Negative control: Raji whole cell lysate Secondary antibody: #JP20040 at 1/10000 dilution Predicted MW: 45kDa Observed MW: 70kDa Exposure time: 90s

Rabbit anti-CD155 Recombinant Monoclonal Antibody(289-68)

IHC shows positive staining in paraffin-embedded human cerebral cortex. Anti-CD155/PVR antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

Rabbit anti-CD155 Recombinant Monoclonal Antibody(289-68)

IHC shows positive staining in paraffin-embedded human prostate. Anti-CD155/PVR antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

Rabbit anti-CD155 Recombinant Monoclonal Antibody(289-68)

IHC shows positive staining in paraffin-embedded human hepatocellular carcinoma. Anti-CD155/PVR antibody was used at 1/2000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

Rabbit anti-CD155 Recombinant Monoclonal Antibody(289-68)

IHC shows positive staining in paraffin-embedded human breast cancer. Anti-CD155/PVR antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

Rabbit anti-p14ARF Monoclonal Antibody(JRMR-263)

Rabbit anti-p14ARF Monoclonal Antibody(JRMR-263)别名宿主反应种属应用分子量纯化方法类型克隆号同种型储存/保存方法背景说明细胞定位UniProt

概述
别名
p14ARF 抗体;ARF; MLM; CDKN2; CDKN2A
宿主
Rabbit
反应种属
Human
应用
WB:1:2000; IHC-P:1:200-1:1000; ICC/IF:1:50;
分子量
Predicted molecular weight: 14kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
性能
纯化方法
Protein A
类型
Monoclonal Antibody
克隆号
JRMR-263
同种型
IgG
储存/保存方法
储存温度:-20℃,避免反复冻融
靶标
背景说明
能够在G1和G2期诱导细胞周期停滞。 充当抑癌剂。与MDM2结合并通过将其螯合在核仁中来阻止其核质穿梭。这通过阻止MDM2诱导的p53降解并增强p53依赖性反式激活和凋亡来抑制MDM2的致癌作用。通过阻止细胞周期蛋白B1 / CDC2复合物的激活,还以p53独立的方式诱导G2阻滞和凋亡。与BCL6结合并下调BCL6诱导的转录抑制。
细胞定位
线粒体,细胞核
UniProt
Q8N726

Rabbit anti-Ku80 Monoclonal Antibody(JRMR-205-1)

Rabbit anti-Ku80 Monoclonal Antibody(JRMR-205-1)别名宿主反应种属应用纯化方法类型克隆号同种型储存/保存方法背景说明细胞定位UniProt

概述
别名
Ku80 抗体;XRCC5
宿主
Rabbit
反应种属
Human, Mouse
应用
IHC-P:1:200-1:1000; ICC/IF:1:50;
性能
纯化方法
Protein A
类型
Monoclonal Antibody
克隆号
JRMR-205-1
同种型
IgG
储存/保存方法
储存温度:-20℃,避免反复冻融
靶标
背景说明
Ku蛋白是有两条多肽链通过非共价键紧密结合形成的异源二聚体结构,分别称为Ku70和Ku80,与DNA依赖蛋白激酶催化亚基结合形成依赖蛋白激酶全酶。是重组修复系统中最重要的组成部分,再维持端粒结构、免疫球蛋白重组、DNA转录及细胞凋亡等方面有着重要的作用。
细胞定位
细胞核
UniProt
P13010

Rabbit anti-PINP Recombinant Monoclonal Antibody(237-59)

Rabbit anti-PINP Recombinant Monoclonal Antibody(237-59)别名宿主反应种属应用免疫原形式浓度纯化方法类型克隆号储存/保存方法存储溶液背景说明UniProt

概述
别名
N-terminal propeptide of type 1 precollagen
宿主
Rabbit
反应种属
Human
应用
Sandwich ELISA
免疫原
Recombinant protein
性能
形式
Liquid
浓度
2 mg/ml
纯化方法
Protein A affinity column
类型
Monoclonal Antibody
克隆号
237-59
储存/保存方法
Store at 2 to 8℃ for one year.
存储溶液
PBS, pH 7.4, 0.03% Proclin 300
靶标
背景说明
N-terminal propeptide of type 1 precollagen (P1NP) is one of the markers of bone formation. Osteoblasts contain a large amount of typeⅠprecollagen. During bone formation, typeⅠprocollagen is secreted outside the cell and cleaved by specific protease to form typeⅠcollagen N-terminal procollagen of type 1 precollagen (P1NP) and C-terminal procollagen of type 1 precollagen, PICP) and typeⅠcollagen 3 fragments. Type I collagen is assembled in osteoid where inorganic minerals (calcium and phosphorus) are deposited to form hydroxyapatite (osteoid mineralization). P1NP and PICP enter the blood and urine as metabolites, so the detection of P1NP and PICP can reflect the level of bone formation. As the research evidence of P1NP reflecting bone formation is richer than PICP, P1NP is a better marker of bone formation. P1NP has good specificity, little influence on circadian rhythm and feeding, and is stable at room temperature. At present, P1NP is generally recommended as the preferred bone formation marker.
UniProt
P02452

实验结果图

Rabbit anti-PINP Recombinant Monoclonal Antibody(237-59)

配对表格

Rabbit anti-CSF-1R Monoclonal Antibody(JRMR-227)

Rabbit anti-CSF-1R Monoclonal Antibody(JRMR-227)别名宿主反应种属应用纯化方法类型克隆号同种型储存/保存方法背景说明细胞定位UniProt

概述
别名
CSF-1R 抗体;CSF-1R; M-CSF-R; CD115; CSF1R; FMS
宿主
Rabbit
反应种属
Human, Mouse
应用
IHC-P:1:500-1:2000; ICC/IF:1:50;
性能
纯化方法
Protein A
类型
Monoclonal Antibody
克隆号
JRMR-227
同种型
IgG
储存/保存方法
储存温度:-20℃,避免反复冻融
靶标
背景说明
酪氨酸蛋白激酶作为CSF1和IL34的细胞表面受体,在调节造血前体细胞(尤其是单核吞噬细胞,例如巨噬细胞和单核细胞)的存活,增殖和分化中起着至关重要的作用。响应于IL34和CSF1促进促炎性趋化因子的释放,从而在先天免疫和炎症过程中发挥重要作用。在破骨细胞增殖和分化的调节,骨吸收的调节中起重要作用,并且是正常骨骼和牙齿发育所必需的。正常的男性和女性生育能力,以及怀孕期间乳腺的乳腺导管和腺泡结构正常发育所必需。促进肌动蛋白细胞骨架的重组,调节膜褶皱的形成,细胞粘附和细胞迁移,并促进癌细胞侵袭。
细胞定位
UniProt
P07333

Rabbit anti-SATB1 Monoclonal Antibody(JRMR-251)

Rabbit anti-SATB1 Monoclonal Antibody(JRMR-251)别名宿主反应种属应用纯化方法类型克隆号同种型储存/保存方法背景说明细胞定位UniProt

概述
别名
SATB1 抗体;DNA-binding protein SATB1; Special AT-rich sequence-binding protein 1
宿主
Rabbit
反应种属
Mouse, Rat
应用
IHC-P:1:200-1:1000;
性能
纯化方法
Protein A
类型
Monoclonal Antibody
克隆号
JRMR-251
同种型
IgG
储存/保存方法
储存温度:-20℃,避免反复冻融
靶标
背景说明
至关重要的沉默因子,有助于启动由Xist RNA介导的X灭活,Xist RNA发生在胚胎发生过程中和淋巴瘤中(通过相似性)。 在特殊的富含AT的序列(共有SATB1结合序列(CSBS))上与DNA结合,位于核基质或支架相关区域。 认为可以识别双链DNA的糖磷酸结构。 转录阻遏物通过与DNA的基质附着区(MARs)结合并诱导局部染色质环重塑,以磷酸化和乙酰化状态依赖的方式控制核和病毒基因的表达。 充当多种染色质重塑酶(例如MHC-1位点的PML)的停靠位点,并且还通过直接向启动子和增强子募集corepressors(HDAC)或共激活因子(HATs)。
细胞定位
细胞核
UniProt
Q01826