Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

KIDINS220抗体;Kinase D-interacting substrate of 220 kDa; Ankyrin repeat-rich membrane-spanning protein; KIDINS220; ARMS; KIAA1250

Rabbit

This KIDINS220 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1518-1547 amino acids from the C-terminal region of human KIDINS220.

Human

WB~~1:1000

Predicted molecular weight: 197kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Polyclonal Antibody

Rabbit Ig

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Cardiovascular;Neuroscience;Signal Transduction

Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)- induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress- induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

Membrane; Multi-pass membrane protein. Late endosome. Note=Localized at late endosome before or after nerve growth factor (NGF) stimulation

Q9ULH0

Wu, Z., et al. J. Biol. Chem. 283(42):28198-28215(2008)
Sniderhan, L.F., et al. Mol. Cell. Neurosci. 38(3):404-416(2008)
Li, J., et al. J. Biol. Chem. 283(5):2614-2621(2008)
Liao, Y.H., et al. Cancer Res. 67(24):11547-11556(2007)
Bracale, A., et al. Mol. Biol. Cell 18(1):142-152(2007)