BioXCell热销产品—InVivoMAb anti-human CD3
克隆号OKT-3单克隆抗体能与人CD3ε反应,CD3ε是一种属于免疫球蛋白超家族的20 kDa跨膜细胞表面蛋白。CD3ε是结合形成TCR复合物的五条多肽链之一。CD3ε在T淋巴细胞、NK-T细胞和发育中的胸腺细胞上均有不同程度的表达。CD3在TCR信号传导、T淋巴细胞活化和抗原识别中起作用。OKT-3抗体在体内具有免疫抑制特性,已被证明能有效治疗肾脏、心脏和肝脏移植排斥反应。
产品详情
产品货号 |
BE0001-2 |
产品规格 |
1/5/25/50/100mg |
抗体亚型 |
Mouse IgG2a, κ |
推荐同型对照 |
InVivoMAb mouse IgG2a isotype control, unknown specificity(货号:BE0085) |
推荐抗体稀释液 |
InVivoPure™ pH 7.0 Dilution Buffer(货号:IP0070) |
免疫原 |
Not available or unknown |
应用 |
in vitro T cell stimulation/activation in vivo T cell depletion in humanized mice ex vivo T cell inhibition for xenografts Flow cytometry |
产品形式 |
PBS , pH 7.0 Contains no stabilizers or preservatives |
内毒素水平 |
<2eu>μ |
g)
使用 LAL gel clotting 测定
纯度
>95% Determined by SDS-PAGE
无菌处理
0.2 μM filtered
生产形式
从组织培养上清液中纯化得到。
纯化形式
Protein G
RRID
AB_1107632
分子量大小
150 kDa
保存条件
抗体原溶液应保存在4°C条件下,不要冷冻保存。
已发表参考文献:
in vitro T cell stimulation/activation |
Hill, E. V., et al. (2015). “Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter.” Eur J Immunol 45(4): 1103-1115. |
in vivo T cell depletion in humanized mice |
Wunderlich, M., et al. (2014). “OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues.” Blood 123(24): e134-144. |
Flow cytometry |
Willing, A., et al. (2014). “CD8(+) MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL-18 serum levels in multiple sclerosis.” Eur J Immunol 44(10): 3119-3128. |
详情请咨询 BioXcell 中国代理商–上海金畔生物科技