BTB-06584
货号：
IB1850
品牌：
Jinpan
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产品简介
| 有效期 | 2年 |
| 描述 | 是一种选择性的且依赖 IF1 的线粒体 F1Fo-ATPase 抑制剂。 |
| MDL | MFCD01753356 |
| CAS | 219793-45-0 |
| 分子式 | C19H12ClNO6S |
| 分子量 | 417.82 |
| 储存条件 | -20℃ |
| 纯度 | ≥98% |
| 外观（性状） | White to off white Powder |
| 单位 | 瓶 |
| 生物活性 | BTB06584 is a selective and IF1-dependent mitochondrial F1Fo-ATPase inhibitor without compromising ATP synthesis. BTB06584 can delays ischaemic cell death[1]. |
| In Vitro | In HL-1 cells, BTB06584 (100 μM) inhibits F1Fo-ATPase activity with no effect on the mitochondrial membrane potential (ΔΨm ) or O2 consumption. BTB06584 (100 μM) pretreatmet protects against ischaemic cell death in HL-1 cells prior to a period of ischaemia. ATP consumption is decreased following inhibition of respiration, and ischaemic cell death is reduced[1]. |
| In Vivo | BTB06584 (1 μM; 24 hours) treatment rescued defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the Atpif1a gene is lost. The concentrations of BTB06584 that restore haemoglobin biosynthesis also alter mitochondrial bioenergetics in living fish[1]. |
| SMILES | ClC1=CC=C(C(OC2=C([N+]([O-])=O)C=CC(S(C3=CC=CC=C3)(=O)=O)=C2)=O)C=C1 |
| 靶点 | ATP Synthase |
| 数据来源文献 | [1]. Ivanes F, et al. The compound BTB06584 is an IF1 -dependent selective inhibitor of the mitochondrial F1 Fo-ATPase. Br J Pharmacol. 2014 Sep;171(18):4193-4206. |
| 规格 | 5mg 10mg |