标签归档：fti

FTI 277

发表于由

FTI 277CAS号： 170006-73-2分子式： C22H29N3O3S2·C2HF3O2分子量： 561.64描述纯度储存/保存方法别名可溶性/溶解性靶点

产品描述
描述

FTI 277 is an inhibitor that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 nM respectively) and disrupts constitutive H-Ras-specific actvation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
纯度
>98%
储存/保存方法
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名
FTI-277,FTI277
可溶性/溶解性
Soluble in Water: ≥2 mg/mL
生物活性
靶点
Farnesyl Transferase

分子结构图

FTI 277

FTI-277盐酸盐

发表于由

FTI-277盐酸盐

货号：
IF1240

品牌：
Jinpan

FTI-277盐酸盐

暂无详情
产品简介
有效期 2年
MDL MFCD06411717
EC EINECS 604-604-1
英文名称 FTI-277 Hydrochloride
CAS 180977-34-8
分子式 C22H29N3O3S2·HCl
分子量 484.07
储存条件 2-8℃
纯度 ≥98%
外观（性状） White to off-white Powder
单位 瓶
SMILES CSCC[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O.[H]Cl
靶点 Farnesyl Transferase
规格 2mg 5mg
是一种有效的选择性farnesyltransferase (FTase)抑制剂。

FTI-2628

发表于由

FTI-2628分子式： C31H34N4O3S分子量： 542.69描述应用纯度储存/保存方法形态密度沸点可溶性/溶解性PubChem CID

产品描述
描述
FTI-2628 is a cell-permeable benzyl ester prodrug form of FTI-2148 that preferentially inhibits protein farnesyltransferase activity over protein geranylgeranyltransferase-I. The compound displays anti-malarial properties. FTI-2628 potently disrupts Ras farnesylation in H-Ras-transformed NIH 3T3 cells and inhibits the growth of P. falciparumi in red blood cells.
应用
A cell-permeable benzyl ester from of FTI-2148
纯度
≥95%
储存/保存方法
Store at -20° C
形态
Solid
基本信息
密度
1.216 g/cm3
沸点
768.19° C at 760 mmHg (Predicted)
可溶性/溶解性
Soluble in DMSO or Methanol
PubChem CID
16760438

FTI-276 trifluoroacetate salt

发表于由

FTI-276 trifluoroacetate saltCAS号： 170006-72-1(non-salt)分子式： C21H27N3O3S2•C2HF3O2分子量： 547.61描述应用储存/保存方法形态别名可溶性/溶解性MDLPubChem CID

产品描述
描述
FTI-276 trifluoroacetate salt is a highly potent RasCAAX peptidomimetic which antagonizes both H and K-Ras oncogenic signaling. This compound inhibits farnesyltransferase (Ftase) in vitro with an IC50 of 500 pM. RasCAAX as an anti-cancer agent.
应用
A highly potent RasCAAX peptidomimetic
储存/保存方法
Desiccate at -20° C
形态
Solid
基本信息
别名
N-[4-[2-(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine trifluoroacetate salt
可溶性/溶解性
Soluble in Water: >5 mg/mL
MDL
MFCD06409253
PubChem CID
395753

FTI 277 hydrochloride

发表于由

FTI 277 hydrochlorideCAS号： 180977-34-8分子式： C22H30ClN3O3S2分子量： 484.07描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)参考文献

产品描述
描述

FTI 277 hydrochloride is the methyl ester of FTI 277, which is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I.
纯度
＞98%
储存/保存方法
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名
FTI 277 HCl；FTI 277
外观
amorphous semi-solid
可溶性/溶解性
DMSO : 89 mg/mL (183.9 mM)

Ethanol : 12 mg/mL (24.8 mM)

Water : 14 mg/mL (28.9 mM)
生物活性
靶点
FTase
In vitro(体外研究)
FTI-277 inhibits Ras processing with an IC50 of 100 nM, but not the geranylgeranylated Rap1A processing in whole cells. FTI-277 induces accumulation of cytoplasmic non-farnesylated H-Ras, accumulates inactive Ras/Raf complexes in the cytoplasm, and blocks constitutive MAPK activation in H-RasF cells. FTI-277 causes increased apoptosis after irradiation and increases radiosensitivity in H-ras-transformed rat embryo cells. FTI-277 also inhibits cell growth and induces apoptosis in drug-resistant myeloma tumor cells. In SH-SY5Y cells, FTI-277 diminishes the toxic effects of methamphetamine on induction in cell degeneration, activation in c-Jun-N-terminal kinase cascades, and Ras activation.
In vivo(体内研究)
In mice coinfected with hepatitis B virus (HBV) and HDV, FTI-277 (50 mg/kg/d i.p.) effectively clears HDV viremia.
参考文献
参考文献
  • 1. Lerner EC, et al. J Biol Chem. 1995, 270(45), 26802-26806.
  • 2. Bernhard EJ, et al. Cancer Res. 1996, 56(8), 1727-1730.
    		•

    分子结构图

    FTI 277 hydrochloride