标签归档：cil

CIL品牌代理商

发表于由

上海金畔生物科技有限公司是CIL品牌代理商 ，欢迎访问官网了解更多产品信息和订购。
CIL

简要描述：

CIL剑桥标准品是世界上生产稳定性同位素标记化合物的生产商，以其技术雄踞同位素分离领域。20年来，CIL一直研究稳定性同位素与稳定性同位素标记化合物的开发，生产。主要标记性同位素有13C、12C、D、15N、18O和17O，目前已经拥有8000多种标记化合物。CIL的产品均能应用于不同的领域，如物理，化学，生物医学，分析，诊断研究以及环境测试。

CIL剑桥标准品是世界上生产稳定性同位素标记化合物的生产商，以其的技术雄踞同位素分离领域。20年来，CIL一直研究稳定性同位素与稳定性同位素标记化合物的开发，生产。主要标记性同位素有13C、12C、D、15N、18O和17O，目前已经拥有8000多种标记化合物。CIL的产品均能应用于不同的领域，如物理，化学，生物医学，分析，诊断研究以及环境测试。

 

Cambridge Isotope Laboratories, Inc. (CIL) is the world's premier producer of stable isotope labeled compounds and the world leader in the field of isotope separations with an annual production capacity of 120 kilograms of Carbon-13 and annual production capacity of 250 kilograms of Oxygen-18. For more than 20 years, CIL has specialized in the development, production, and marketing of stable (non-radioactive) isotopes and chemical compounds labeled with stable isotopes. With an inventory of over 8000 products, CIL has the most complete product offering of stable isotope labeled compounds available. 

 

CIL employs 130 people at its state-of-the-art 57,000 square foot Andover, Massachusetts production laboratories and its Xenia, Ohio isotope separation facility. CIL's chemists are experts in their fields, with extensive years of experience exclusively in the synthesis of stable isotope labeled compounds.

 

产品列表：

CIL(Cambridge Isotope Laboratories)

CDNLM-6786-PK  

(AMINOMETHYL)PHOSPHONIC ACID (AMPA) 

(13C, 99%; 15N, 98%; METHYLENE-D2, 98%)

  

CIL(Cambridge Isotope Laboratories)

CLM-6620-1.2  

1,2,2-TRIMETHYLPROPYL HYDROGEN 

METHYLPHOSPHONATE (TRIMETHYLPROPYL-13C6, 99%) 

100 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-9895-1.2  

1-PROPYLPHOSPHONIC ACID UNLABELED 

1000 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

CDNLM-6786-1.2  

AMINOMETHYLPHOSPHONIC ACID (13C, 99%;

15N, 98%;METHYLENE-D2,98%) 100 UG/ML H2O

1.2 ML

CIL(Cambridge Isotope Laboratories)

CLM-4806-PK  

BETA-THIODIGLYCOL (13C4, 99%)

  

CIL(Cambridge Isotope Laboratories)

ERC-034  

CYCLOHEXYL METHYLPHOSPHONIC ACID UNLABELED 

1000UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ES-5548-10X  

DIALKYL PHOSPHATE AND PHOSPHOROTHIOATE 

NATIVE UNLABELED 100 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ERD-119  

O,O-DIETHYL HYDROGEN THIOPHOSPHATE POTASSIUM 

SALT UNLABELED 1000 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-9897-1.2  

DIETHYL METHYLPHOSPHONATE UNLABELED 

1000 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

DLM-4851-M-1.2  

O,O-DIETHYLPHOSPHORIC ACID, POTASSIUM 

SALT (DIETHYL-D10, 98%) 100 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-9287-M-1.2  

O,O-DIETHYLPHOSPHORIC ACID, POTASSIUM 

SALT UNLABELED 100 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

DLM-9003-1.2  

O,O-DIETHYLPHOSPHORODITHIOATE, POTASSIUM 

SALT (DIETHYL-D10, 98%)100 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

DLM-4852-1.2  

O,O-DIETHYLPHOSPHOROTHIOATE, POTASSIUM 

SALT (DIETHYL-D10, 98%) 100 UG/ML IN MEOH

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-9898-1.2  

DIISOPROPYL METHYLPHOSPHONATE UNLABELED 

1000 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-9896-1.2  

DIMETHYL METHYLPHOSPHONATE UNLABELED 

1000 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

DLM-8868-1.2  

O,O-DIMETHYLPHOSPHORIC ACID, POTASSIUM SALT 

(DIMETHYL-D6, 98%) 100 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

DLM-8904-1.2  

O,O-DIMETHYLPHOSPHOROTHIOATE, POTASSIUM SALT 

(DIMETHYL-D6,98%) 100 UG/ML IN METHANOL 97%+ PURE

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-8905-1.2  

O,O-DIMETHYLPHOSPHOROTHIOATE, POTASSIUM 

SALT UNLABELED 1000 UG/ML IN METHANOL 97%+PURE

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-9899-1.2  

DIPINACOLYL METHYLPHOSPHONATE UNLABELED 

1000 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-9887-1.2  

1,4-DITHIANE UNLABELED 1000 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-6091-1.2  

ETHYL HYDROGEN DIMETHYLAMIDOPHOSPHATE, SODIUM SALT 

90% CHEM. PURITY UNLABELED 1000 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

DLM-6098-1.2  

ETHYL HYDROGEN METHYLPHOSPHONATE 

(ETHYL-D5, 98%) 100 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-9893-1.2  

N-ETHYLDIETHANOLAMINE UNLABELED 

1000 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-9948-1.2  

ETHYLPHOSPHONIC ACID UNLABELED 

1000 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ERI-017  

ISOPROPYL METHYLPHOSPHONIC ACID (D7, 98%) 

1000 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-9892-1.2  

N-METHYLDIETHANOLAMINE UNLABELED 

1000 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

CDLM-6100-1.2  

METHYLPHOSPHONIC ACID (13C, 99%; METHYL-D3, 

98%) 100 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

DLM-6196-1.2  

METHYLPHOSPHONIC ACID (METHYL-D3, 98%) 100 

UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ERM-038  

METHYLPHOSPHONIC ACID UNLABELED 1000 UG/ML 

IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-6619-1.2  

METHYLPHOSPHONIC ACID, MONO-(1,2,2-TRIMETHYL

– PROPYL) ESTER UNLABELED 1000 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-6099-1.2  

METHYLPHOSPHONIC ACID, MONOETHYL 

ESTER UNLABELED 1000 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-6093-1.2  

METHYLPHOSPHONIC ACID, MONOISOPROPYL 

ESTER UNLABELED 1000 UG/ML IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-9894-1.2  

PINACOLYL ALCOHOL UNLABELED 1000 UG/ML 

IN METHANOL

1.2 ML

CIL(Cambridge Isotope Laboratories)

ULM-9886-1.2  

2-PROPYLPHOSPHONIC ACID UNLABELED 

1000 UG/ML IN METHANOL

1.2 ML

 

CIL（Cambridge Isotope Laboratories）品牌代理商

发表于由

上海金畔生物科技有限公司是CIL（Cambridge Isotope Laboratories）品牌代理商 ，欢迎访问官网了解更多产品信息和订购。
CIL（Cambridge Isotope Laboratories）

简要描述：

CIL剑桥标准品是世界上一个生产稳定性同位素标记化合物的生产商，以高超的技术雄踞同位素分离领域。

CIL剑桥标准品是世界上一个生产稳定性同位素标记化合物的生产商，以高超的技术雄踞同位素分离领域。20年来，CIL一直研究稳定性同位素与稳定性同位素标记化合物的开发，生产。主要标记性同位素有13C、12C、D、15N、18O和17O，目前已经拥有8000多种标记化合物。CIL的产品均能应用于不同的领域，如物理，化学，生物医学，分析，诊断研究以及环境测试。

Cambridge Isotope Laboratories, Inc. (CIL) is the world's premier producer of stable isotope labeled compounds and the world leader in the field of isotope separations with an annual production capacity of 120 kilograms of Carbon-13 and annual production capacity of 250 kilograms of Oxygen-18. For more than 20 years, CIL has specialized in the development, production, and marketing of stable (non-radioactive) isotopes and chemical compounds labeled with stable isotopes. With an inventory of over 8000 products, CIL has the most complete product offering of stable isotope labeled compounds available. 产品列表：


CDNLM-6786-PK  

(13C, 99%; 15N, 98%; METHYLENE-D2, 98%)

CLM-6620-1.2  

METHYLPHOSPHONATE (TRIMETHYLPROPYL-13C6, 99%) 

1.2 ML

ULM-9895-1.2  

1000 UG/ML IN METHANOL

CIL(Cambridge Isotope Laboratories)

AMINOMETHYLPHOSPHONIC ACID (13C, 99%;

1.2 ML

CLM-4806-PK  

CIL(Cambridge Isotope Laboratories)

CYCLOHEXYL METHYLPHOSPHONIC ACID UNLABELED 

1.2 ML

ES-5548-10X  

NATIVE UNLABELED 100 UG/ML IN METHANOL

CIL(Cambridge Isotope Laboratories)

O,O-DIETHYL HYDROGEN THIOPHOSPHATE SALT UNLABELED 1000 UG/ML IN METHANOL

CIL(Cambridge Isotope Laboratories)

DIETHYL METHYLPHOSPHONATE UNLABELED 

1.2 ML

DLM-4851-M-1.2  

SALT (DIETHYL-D10, 98%) 100 UG/ML IN METHANOL

CIL(Cambridge Isotope Laboratories)

O,O-DIETHYLPHOSPHORIC ACID, POTASSIUM 

UNLABELED 100 UG/ML IN METHANOL

CIL(Cambridge Isotope Laboratories)

O,O-DIETHYLPHOSPHORODITHIOATE, POTASSIUM 

1.2 ML

DLM-4852-1.2  

SALT (DIETHYL-D10, 98%) 100 UG/ML IN MEOH

CIL(Cambridge Isotope Laboratories)

DIISOPROPYL METHYLPHOSPHONATE UNLABELED 

1.2 ML

ULM-9896-1.2  

1000 UG/ML IN METHANOL

CIL(Cambridge Isotope Laboratories)

O,O-DIMETHYLPHOSPHORIC ACID, POTASSIUM SALT 

1.2 ML

DLM-8904-1.2  

ALT 

1.2 ML

ULM-8905-1.2  

SALT UNLABELED 1000 UG/ML IN METHANOL 97%+PURE

CIL(Cambridge Isotope Laboratories)

DIPINACOLYL METHYLPHOSPHONATE UNLABELED 

1.2 ML

ULM-9887-1.2  

1.2 ML

ULM-6091-1.2  

90% CHEM. PURITY UNLABELED 1000 UG/ML IN METHANOL

CIL(Cambridge Isotope Laboratories)

ETHYL HYDROGEN METHYLPHOSPHONATE 

1.2 ML

ULM-9893-1.2  

1000 UG/ML IN METHANOL

CIL(Cambridge Isotope Laboratories)

ETHYLPHOSPHONIC ACID UNLABELED 

1.2 ML

ERI-017  

1000 UG/ML IN METHANOL

CIL(Cambridge Isotope Laboratories)

N-METHYLDIETHANOLAMINE UNLABELED 

1.2 ML

CDLM-6100-1.2  

98%) 100 UG/ML IN METHANOL

CIL(Cambridge Isotope Laboratories)

METHYLPHOSPHONIC ACID (METHYL-D3, 98%) 100 

1.2 ML

ERM-038  

IN METHANOL

CIL(Cambridge Isotope Laboratories)

METHYLPHOSPHONIC ACID, MONO-TRIMETHYL

1.2 ML

ULM-6099-1.2  

ESTER UNLABELED 1000 UG/ML IN METHANOL

CIL(Cambridge Isotope Laboratories)

METHYLPHOSPHONIC ACID, MONOISOPROPYL 

1.2 ML

ULM-9894-1.2  

IN METHANOL

CIL(Cambridge Isotope Laboratories)

2-PROPYLPHOSPHONIC ACID UNLABELED 

1.2 ML

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CA-3

发表于由

CA-3

货号：
IC2240

品牌：
Jinpan

CA-3

暂无详情

CA-3

暂无详情
产品简介
有效期 2年
描述 是一种有效的选择性ferroptosis 诱导剂。
别名 CIL-56
CAS 300802-28-2
分子式 C23H27N3O5S2
分子量 489.61
储存条件 -20℃
纯度 ≥98%
外观（性状） Solid
单位 瓶
生物活性 CA3 (CIL56) 对YAP1/Tead转录活性具有有效的抑制作用，主要靶向高表达YAP1、具有癌症干细胞属性的、难治疗的食管腺癌细胞。CA3(CIL56)可诱导铁死亡和铁依赖的活性氧自由基。[1]
In Vitro CA3可强有效地抑制食管腺癌细胞生长。CA3抑制肿瘤细胞的增殖、诱导凋亡、减少肿瘤球的形成以及ALDH1+细胞群体数量。在293T细胞中，CA3特别地抑制Tead/YAP1转录活性，但对其他转录因子Super-TOP/Wnt、CBF1/Notch和AP-1没有抑制活性。在耐辐射的食管腺癌细胞中，CA3优先抑制其癌症干细胞属性[1]。
In Vivo 在移植瘤模型中，CA3可发挥强有效的抗肿瘤活性，而不具有明显毒性作用[1]。
SMILES O=S(C1=CC2=C(C=C1)C3=C(C=C(S(=O)(N4CCCCC4)=O)C=C3)/C2=NO)(N5CCCCC5)=O
靶点 Ferroptosis
动物实验 SKGT-4 (PIN20YAP1) cells (1 x 106) without (Dox- ) or with (Dox+) YAP1 induction by doxycycline were inoculated into nude mice (n= 5/group). The mice in the Dox+ group were fed drinking water containing 2.5% sucrose and 2.5% doxycycline, whereas those in the Dox- group were fed water containing only 2.5% sucrose. After 10 days, CA3 was intraperitoneally injected into the animals in the Dox+ group at 1 mg/kg/mouse three times a week for total 3 weeks. In a JHESO xenograft model of esophageal adenocarcinoma, 2×106 JHESO cells were subcutaneously injected into nude mice (n=5/group). After about 10 days, the mice underwent intra_x005fperitoneal injection of CA3 at 1 mg/kg/mouse, 5-FU at 30 mg/kg/mouse, or a combination of them three times a week for total 3 weeks. A control group was given PBS at 100 mL/mouse. The mice’s tumor volumes, tumor weights, and body weights were measured as described previously. All measurements were compared using an unpaired Student t test.[1]
细胞实验 The esophageal adenocarcinoma cells and their resistant counterparts were treated with 0.1% DMSO (control), CA3 at different doses. For combination treatment experiments, treatment of the cells with CA3, 5-FU, or a combination at different concentrations was administered for 6 days as indicated, and the cell viability was assessed using an MTS assay as described previously. All assays were performed in triplicate and repeated at least three times.[1]
数据来源文献 [1] Song S, et al. Mol Cancer Ther. 2018, 17(2):443-454.
规格 2mg 5mg