Cefoselis sulfate/FK-037；硫酸头孢噻利
货号：
IC1850
品牌：
Jinpan
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产品简介
| MDL | MFCD00864819 |
| EC | EINECS 1533716-785-6 |
| 别名 | 头孢噻利硫酸盐;Wincef;Winsef;FK037 |
| 英文名称 | Cefoselis sulfate/FK-037 |
| CAS | 122841-12-7 |
| 分子式 | C19H22N8O6S2.H2SO4 |
| 分子量 | 620.64 |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| 生物活性 | Cefoselis is a widely used beta-lactam antibiotic. [1] |
| In Vitro | Cefoselis had strong antibacterial activity against β-lactamases(ESBLs+AmpC) non-producers(46.1%) of Enterobacteriaceae,and good antibacterial activity against the clinical isolates producing AmpC alone(11.2%).However,cefoselis showed poor activity against ESBLs producing clinical isolates(42.7%).Its activity against Pseudomonas aeruginosa and Acinetobacter lwoffi was moderate.The activity was poor for Acinetobacter baumannii.Cefoselis showed potent antibacterial activity against Hemophilus influenzae and Moraxella catarrhalis.Cefoselis was highly active against MSSA and MSCNS,and showed potent antibacterial activity against all penicillin-susceptible Streptococcus pneumoniae(PSSP) and other Streptococcus spp.Its activity was slightly lower for penicillin-intermediate Streptococcus pneumoniae(PISP).[2] |
| In Vivo | Cefoselis was dose-dependently appeared in brain extracellular fluid in proportion to its blood level. The elimination constant from brain extracellular fluid (apparent) was slightly lower than that from blood. These results indicated that cefoselis might penetrate the BBB or be discharged by a certain transport system.[1] In renal dysfunction rats, the elimination half-lives of cefoselis from both blood and brain were extensively prolonged. [1] |
| SMILES | O=C(C(N12)=C(CN3N(CCO)C(C=C3)=N)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=NOC)=O)C1=O)O.O=S(O)(O)=O |
| 靶点 | Bacterial |
| 数据来源文献 | [1]. K Ohtaki, et al. Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. J Neural Transm (Vienna). 2004 Dec;111(12):1523-35. [2]. ZHU, D., et al., In vitro activities of cefoselis compared to β-lactams and other antibacterial agents aganst gram-positive and gram-negative clinical isolates. Chinese Journal of Infection and Chemotherapy, 2011. 4: p. 002. |
| 规格 | 5mg 25mg 50mg |
Cefoselis硫酸盐是β-内酰胺抗生素。