Cedrol 雪松醇 标准品
| CAS | 77-53-2 |
| 分子式 | C15H26O |
| 分子量 | 222.380005 |
| 储存条件 | Store in dry and dark place. |
| 纯度 | GC :≥98% |
| 单位 | 瓶 |
| 货期 | 4周 |
| 规格 | 100mg |
Cedrol；雪松醇
| EC | EINECS 201-035-6 |
| MDL | MFCD00062952 |
| 别名 | 柏木脑 |
| 英文名称 | Cedrol |
| CAS | 77-53-2 |
| 分子式 | C15H26O |
| 分子量 | 222.37 |
| 纯度 | GC≥98% |
| 单位 | 支 |
| 生物活性 | Cedrol is bioactive sesquiterpenes found in cedar essential oil and exert antiseptic, anti-inflammatory, antispasmodic, tonic, astringent, diuretic, sedative, insecticidal, and antifungal activities. Cedrol was found to be potent competitive inhibitors of CYP2B6-mediated bupropion hydroxylase . [1-3] |
| In Vitro | Cedrol is an anti-inflammatory constituent, anti-microbial ingredient and antibiosis agent[1]. Cedrol could accelerate fibroblast growth in a dose-dependent manner and increase the production of type 1 collagen and elastin. Phosphorylation of p42/44 extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and Akt are also markedly increased by the treatment of cedrol, indicating that cedrol stimulates ECM production[3]. Cedrol is a potent competitive inhibitor of CYP2B6-mediated bupropion hydroxylase with inhibition constant (Ki) value of 0.9 μM. It also inhibits CYP3A4-mediated midazolam hydroxylation with a Ki value of 3.4 μM while only weakly inhibits CYP2C8, CYP2C9, and CYP2C19 activities[2]. |
| In Vivo | Cedrol can promote hair reproduction. It promotes hair regeneration and shortens the telogen phase of hair follicles after alopecia occurs. Cedrol may possess a latent ability of preventing damage to initiatory hair follicle and restoring the morphological characteristics of follicles after they have been damaged by chemotherapy. Cedrol is a PAF (platelet-activating factor) antagonist that can reduce or inhibit platelet aggregation, skin inflammation, and vascular disorders[1]. |
| SMILES | O[C@]1(C)CC[C@@]23[C@H](C)CC[C@@]2([H])C(C)(C)[C@@]1([H])C3 |
| 靶点 | Cytochrome P450 |
| 数据来源文献 | [1] Chen SS, et al. Environ Toxicol Pharmacol. 2016, 46:270-276. [2] Jeong HU, et al. J Toxicol Environ Health A. 2014, 77(22-24):1522-32. [3] Jin MH, et al. Ann Dermatol. 2012, 24(1):16-21. |
| 规格 | 20mg 50mg 100mg |
Cedrol 是一种生物活性倍半萜，一种有效的细胞色素 P-450(CYP) 酶竞争性抑制剂。