标签归档：cds

胞质DNA感受器 (CDS) 激动剂及相关产品推荐

发表于由

胞质DNA感受器 (CDS) 激动剂及相关产品推荐

CDS可识别受损的、定位错误的、或致病性DNA，进而通过TBK1-IRF3通路诱导I型干扰素的产生。DNA通常定位于细胞核或线粒体中，但当它的合成或运输出现错误时会在细胞浆中聚集。此外，在感染情况下，病毒或微生物的DNA也可以进入到宿主细胞的细胞浆中。许多CDS已经被报道，包括腺苷脱氨酶DAI、解旋酶DDX41、干扰素诱导的IF116蛋白，以及cGAS(环-GMP-AMP合成酶)。AIM2是另外一种胞浆脱氧核糖核酸传感器，它受到刺激后形成炎症小体并进一步诱导产生IL-1®。

相关产品推荐：

PRODUCT

ORIGIN/DESCRIPTION

GRADE*

WORKING

CONCENTRATION

QTY

CATALOG

CODE

CDS Agonists

ODN TTAGGG (A151)

Inhibitory ODN, human preferred

TLR2 -/ TLR4 –

100 nM – 10 µM

200 µg

1 mg

tlrl-ttag151

tlrl-ttag151-1

dsDNA-EC

E. coli K12 genomic DNA

TLR2 -/ TLR4 –

30 ng – 1 µg/ml

200 µg

tlrl-ecdna

G3-YSD                                      NEW

Y-form DNA

TLR2 -/ TLR4 –

100 ng – 1 µg/ml

200 µg

tlrl-ydna

G3-YSD Control                   NEW

Control for Y-form DNA

TLR2 -/ TLR4 –

100 ng – 1 µg/ml

200 µg

tlrl-ydnac

HSV-60 Naked

HSV1-derived 60 bp oligonucleotide

TLR2 -/ TLR4 –

30 ng – 10 µg/ml

200 µg

tlrl-hsv60n

HSV-60 LyoVec™

Precomplexed HSV1-derived 60 bp ODN

TLR2 -/ TLR4 –

300 ng – 10 µg/ml

100 µg

tlrl-hsv60c

HSV-60c Naked

Control for HSV-60 ODN

TLR2 -/ TLR4 –

30 ng – 10 µg/ml

200 µg

tlrl-hsv60cn

HSV-60c/LyoVec™

Precomplexed control for HSV-60 ODN

TLR2 -/ TLR4 –

300 ng – 10 µg/ml

100 µg

tlrl-hsv60cc

ISD Naked

Interferon stimulatory DNA

TLR2 -/ TLR4 –

100 ng – 10 µg/ml

200 µg

tlrl-isdn

ISD/LyoVec™

Precomplexed interferon stimulatory DNA

TLR2 -/ TLR4 –

300 ng – 10 µg/ml

100 µg

tlrl-isdc

ISD Control Naked

Non-immunostimulatory ODN

TLR2 -/ TLR4 –

100 ng – 10 µg/ml

200 µg

tlrl-isdcn

ISD Control/LyoVec™

Precomplexed non-immunostimulatory ODN

TLR2 -/ TLR4 –

300 ng – 10 µg/ml

100 µg

tlrl-isdcc

Poly(dA:dT) Naked

Poly(dA-dT)•poly(dT-dA)

TLR2 -/ TLR4 –

1 – 5 µg/ml

200 µg

1 mg

tlrl-patn

tlrl-patn-1

Poly(dA:dT)/LyoVec™

Poly(dA-dT)•poly(dT-dA)/LyoVec™ complexes

TLR2 -/ TLR4 –

1 – 5 µg/ml

100 µg

tlrl-patc

Poly(dA:dT)/Rhodamine

Rhodamine labeled poly(dA-dT)•poly(dT-dA)

TLR2 -/ TLR4 –

30 ng – 10 µg/ml

10 µg

tlrl-patrh

Poly(dG:dC) Naked

Poly(dG-dC)•poly(dG-dC)

TLR2 -/ TLR4 –

10 ng – 10 µg/ml

200 µg

tlrl-pgcn

Poly(dG:dC)/LyoVec™

Poly(dG-dC)•poly(dG-dC)/LyoVec™ complexes

TLR2 -/ TLR4 –

10 ng – 10 µg/ml

100 µg

tlrl-pgcc

VACV-70 Naked

Vaccinia virus-derived 70 bp oligonucleotide

TLR2 -/ TLR4 –

30 ng – 10 µg/ml

200 µg

tlrl-vav70n

VACV-70/LyoVec™

Precomplexed vaccinia virus-derived 70 bp ODN

TLR2 -/ TLR4 –

300 ng – 10 µg/ml

100 µg

tlrl-vav70c

VACV-70c Naked

Control for VACV-70 ODN

TLR2 -/ TLR4 –

30 ng – 10 µg/ml

200 µg

tlrl-vav70cn

VACV-70c/LyoVec™

Precomplexed control for VACV-70 ODN

TLR2 -/ TLR4 –

300 ng – 10 µg/ml

100 µg

tlrl-vav70cc

如需订购以上产品或咨询其它技术/产品详情问题，请联系Invivogen代理商上海金畔生物

PRR报告基因细胞：RLR, CDS, STING, ALPK1/TIFA

发表于由

PRR报告基因细胞：RLR, CDS, STING, ALPK1/TIFA

细胞系
 产品名称 通路概述 报告系统* 货号
RLR REPORTER CELLS

A549

(human)

 A549-Dual™ KO-MDA5 NF-κB & IRFs, knockout of human MDA-5 SEAP / Lucia a549d-komda5
A549-Dual™ KO-RIG-I  NF-κB & IRFs, knockout of human RIG-I  SEAP / Lucia a549d-korigi
A549-Dual™ KO-MAVS  NF-κB & IRFs, knockout of human MAVS SEAP / Lucia a549d-komavs

RAW

(mouse)

 RAW-Lucia™ ISG-KO-MDA5 IRFs, knockout of mouse MDA-5 Lucia rawl-komda5
RAW-Lucia™ ISG-KO-RIG-I IRFs, knockout of mouse RIG-I Lucia rawl-korigi
RAW-Lucia™ ISG-KO-MAVS IRFs, knockout of mouse MAVS Lucia Lucia rawl-komavs
HEK293

(human)

 HEK-Lucia™ RIG-I IRFs, overexpression of human RIG-I Lucia hkl-hrigi
THP1

(human)

 THP1-Dual KO MDA-5 NF-κB & IRFs, knockout of human MDA-5 SEAP / Lucia thpd-komda5
THP1-Dual KO RIG-I NF-κB & IRFs, knockout of human RIG-I SEAP / Lucia thpd-korigi
THP1-Dual KO MAVS NF-κB & IRFs, knockout of human MAVS SEAP / Lucia thpd-komavs
CYTOSOLIC DNA SENSORS&STING REPORTER CELLS
B16
(mouse)		 B16-Blue™ISG-KO-STING IRFs， knockout of mouse STING SEAP bb-kostg
HE K 293
(human)		 HEK-Blue™ISG-KO-STING IRFs， knockout of human STING SEAP hkb-kostg
293-Dual™hSTING-A162 Double readout**(IRFs&IFN-B) ， Lucia knocked into IFN-B
S162A human STING transfected		 SEAP/Lucia 293d-a162
293-Dual™hSTING-H232 Double readout**(IRFs&IFN-β) ， Lucia knocked into IFN-β,
R71-G230-H232-R293 human STING transfected		 SEAP/Lucia 293d-h232
HEK-Blue STAT6-hSTING R232 STAT 6-specific SEAP expression SEAP hkb-st6r232
293-Dual™hSTING-R232 Double readout**(IRFs&IFN-β) ， Lucia knocked into IFN-β，
R71-G 230-R232-R293 human STING transfected		 SEAP/Lucia 293d-r232
293-Dual™mSTING Double readout**(IRFs&IFN-β) ， Lucia knocked into IFN-β
mouse STING transfected		 SEAP/Lucia 293d-mstg
RAW
(mouse)		 RAW-Lucia™IS G-KO-cGAS IRFs， knockout of mouse cGAS Lucia rawl-kocgas
RAW-Lucia™IS G-KO-IFI16 IRFs， knockout of mouse IFI16 Lucia rawl-koif16
RAW-Lucia™IS G-KO-STING IRFs， knockout of mouse STING Lucia raw-kostg
Raw-lucia IS G-KO-TREX1 IRFs， knockout of mouse TREX1 Lucia rawl-kotrex
THP-1
(human)		 THP 1-Dual’KO-cGAS NF-KB&IRFs， knockout of human cGAS SEAP/Lucia thpd-kocgas
THP 1-Dual“KO-IFI16 NF-KB&IRFs， knockout of human IFI16 SEAP/Lucia thpd-koifi16
THP 1-Dual’KO-STING NF-KB&IRFs， knockout of human STING SEAP/Lucia thpd-kostg
THP 1-Dual’KI-hSTING-A162 NF-KB&IRFs， knockin of S162A human STING
(DMX A A sensitive isoform		 SEAP/Lucia thpd-a162
THP 1-Dual“KI-hSTING-H232 NF-KB&IRFs， knockin of R 71-G 230-H 232-R 293 human STING SEAP/Lucia thpd-h232
THP 1-Dual’KI hSTING-M155 NF-KB&IRFs， knockin of V155M human STING
(constitutively active isoform)		 SEAP/Lucia thpd-m155
THP 1-Dual’KI-hSTING-R232 NF-KB&IRFs， knockin of R 71-G 230-R 232-R 293“wild-type’human STING SEAP/Lucia thpd-r232
THP 1-Dual’KI-h STINGS154 NF-KB&IRFs， knockin of N154S human STING
(constitutively active isoform)		 SEAP/Lucia thpd-s154
THP 1-Dual’KI-m STING NF-KB&IRFs， knockin of mouse STING SEAP/Lucia thpd-mstg
THP 1-Dual“KO-TREX1 NF-KB&IRFs， knockin of human TREX 1 SEAP/Lucia thpd-kotrex
CYTOSOLIC SENSORS OF INTERMEDIATE METABOLITES OF LPS：ALPK1/TIFA
HE K-Blue’KO-ALPK 1 Knockout(KO) of the ALPK1 gene SEAP hkb-koalpk
HE K-Blue’KO-TIFA Knockout(KO) of the TIFA gene SEAP hkb-kotifa

详情请联系 Invivogen 全国代理-上海金畔生物科技