标签归档：bedaquiline

贝达喹啉

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贝达喹啉

货号：
IB1450

品牌：
Jinpan

贝达喹啉

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产品简介
有效期 2年
描述 是一种二芳基喹啉抗生素，可抑制分枝杆菌ATP合成酶。
MDL MFCD03095271
EC EINECS 1308068-626-2
别名 TMC-207
英文名称 Bedaquiline
CAS 843663-66-1
分子式 C32H31BrN2O2
分子量 555.51
储存条件 -20℃
纯度 ≥98%
外观（性状） Solid
单位 瓶
生物活性 Bedaquiline是一种二芳基喹啉抗生素，可抑制分枝杆菌ATP合成酶。[1-3]
In Vitro Bedaquiline抑制TDR结核分枝杆菌菌株的生长，MIC值范围为0.125至0.5 mg / L [1]。在缓慢生长的分枝杆菌（SGM）中，对苯二酚对鸟分枝杆菌表现出最高的活性，MIC50和MIC90值分别为0.03和16mg / L.在快速生长的分枝杆菌（RGM）中，脓肿分枝杆菌亚种。脓肿（M. abscessus）和脓肿分枝杆菌亚种massiliense（M。massiliense）似乎比偶发分枝杆菌更容易对bedaquiline敏感，两种物种的MIC50和MIC90值分别为0.13和> 16 mg / L. Bedaquiline也显示出对NTM物种的适度体外活性[2]。 Bedaquiline具有优异的抗结核分枝杆菌的体外活性，包括多药耐药的结核分枝杆菌[3]。
SMILES BrC1=CC=C(N=C(OC)C([C@H]([C@@](C2=CC=CC3=C2C=CC=C3)(O)CCN(C)C)C4=CC=CC=C4)=C5)C5=C1
靶点 Bacterial
数据来源文献 [1]. Jang JC, et al. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis. J Microbiol. 2017 Apr 20.
[2]. Pang Y, et al. In Vitro Activity of Bedaquiline against Nontuberculous Mycobacteria in China. Antimicrob Agents Chemother. 2017 Apr 24;61(5).
[3]. Chahine EB, et al. Bedaquiline: a novel diarylquinoline for multidrug-resistant tuberculosis. Ann Pharmacother. 2014 Jan;48(1):107-15.
规格 5mg 10mg

Bedaquiline (TMC207)

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Bedaquiline (TMC207)CAS号： 843663-66-1分子式： C32H31BrN2O2分子量： 555.5描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)

产品描述
描述
TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB.
纯度
>98%
储存/保存方法
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名
贝达喹啉；TMC207；R207910
外观
White to off-white powder
可溶性/溶解性
DMSO : 20 mg/mL (36.00 mM; Need ultrasonic)
生物活性
靶点
Bacterial
In vitro(体外研究)
Bedaquiline inhibits the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L. Among slowly growing mycobacteria (SGM), bedaquiline exhibits the highest activity against Mycobacterium avium with MIC50 and MIC90 values of 0.03 and 16 mg/L, respectively. Among rapidly growing mycobacteria (RGM), Mycobacterium JPcessus subsp. JPcessus (M. JPcessus) and Mycobacterium JPcessus subsp. massiliense (M. massiliense) seem more susceptible to bedaquiline than Mycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and >16 mg/L, respectively, for both species. Bedaquiline also shows moderate in vitro activity against NTM species. Bedaquiline has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis.

分子结构图

Bedaquiline (TMC207)