ATIII; Serpin C1

Rabbit

Human

WB: 1:1000

Recombinant protein

Liquid

0.5 mg/mL

Protein A affinity column

Monoclonal Antibody

294-211

Store at -20℃ for one year.

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Antithrombin III (AT III) is primarily a potent anticoagulant with independent anti-inflammatory properties. AT III irreversibly inhibits serine proteases (e.g. activated factor X and thrombin) in a one-to-one ratio, with the generation of protease–AT III complexes. Heparin prevents AT III from interacting with the endothelial cell surface by binding to sites on the AT III molecule, competing for the AT III binding site, and reducing AT III’s ability to interact with its cellular receptor [PMID: 26862016].

Secreted, Extracellular space

P01008

ATIII

Rabbit

Human

Sandwich ELISA

Recombinant protein

Liquid

2 mg/mL

Protein A affinity column

Monoclonal Antibody

294-303

IgG

Store at 4℃ for one year.

PBS pH7.4, 0.03% Proclin 300

Antithrombin III (ATIII) is a nonvitamin K-dependent protease that inhibits coagulation by neutralizing the enzymatic activity of thrombin (factors IIa, IXa, Xa). Antithrombin III activity is markedly potentiated by heparin, the principal mechanism by which both heparin and low–molecular-weight heparin result in anticoagulation. Thrombin–antithrombin complex (TAT) is a protein complex of thrombin and antithrombin. It is a marker of net activation of coagulation. TAT is formed in response to the high thrombin level caused by coagulation following a ruptured vessel. Since thrombin is rapidly bound by antithrombin, TAT is a useful measure for thrombin level in the blood. Thrombin can pass the blood–brain barrier, destroying neurons and potentially causing cerebral edemas. The half-life of TAT is approximately 15 minutes.

P01008