5-氨基乙酰丙酸盐酸盐
货号：
IA2690
品牌：
Jinpan
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产品简介
| EC | EINECS 226-679-5 |
| MDL | MFCD00012869 |
| 描述 | 是体内血红素生物合成的中间体，为四吡咯的前体。 |
| 别名 | 盐酸-5-氨基左旋糖酸 |
| 英文名称 | 5-Aminolevulinic Acid Hydrochloride |
| CAS | 5451-09-2 |
| 分子式 | C5H9NO3·HCl |
| 分子量 | 167.59 |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| 生物活性 | 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles. 5-Aminolevulinic acid hydrochloride (ALA) is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours. [1-2] |
| In Vitro | Median follow-up was 35.4 months (95% CI 1.0-56.7). Contrast-enhancing tumour was resected completely in 90 (65%) of 139 patients assigned 5-aminolevulinic acid compared with 47 (36%) of 131 assigned white light (difference between groups 29% [95% CI 17-40], p<0.0001). Patients allocated 5-aminolevulinic acid had higher 6-month progression free survival than did those allocated white light (41.0% [32.8-49.2] vs 21.1% [14.0-28.2]; difference between groups 19.9% [9.1-30.7], p=0.0003, Z test) [1]. 5-ALA alone proved to be insufficient in attaining gross total resection without the danger of incurring postoperative neurological deterioration. Furthermore, in the case of functional grade III gliomas, iMRI in combination with functional neuronavigation was significantly superior to the 5-ALA resection technique[2] . |
| SMILES | O=C(O)CCC(CN)=O.[H]Cl |
| 靶点 | Others |
| 数据来源文献 | [1]. Stummer, W., et al., Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol, 2006. 7(5): p. 392-401. [2]. Eyupoglu, I.Y., et al., Improving the extent of malignant glioma resection by dual intraoperative visualization approach. PLoS One, 2012. 7(9): p. e44885. |
| 规格 | 20mg 50mg 100mg |
是一种化合物，具有生物或化学活性。