AKOS037652256CAS号： 2171065-77-1分子式： C24H26ClFN4O4S2分子量： 553.07描述纯度储存/保存方法靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
AKOS037652256 can be used as a TRPML modulator for the treatment of diseases associated with TRPML activity such as lysosomal accumulation disorders, muscular dystrophy, common age-related neurodegenerative diseases, oxidative stress or reactive oxygen species (ROS)-related diseases and ageing.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 生物活性 | |
| 靶点 |
TRPML:< = 2 µM(AC50), TRPML1:< = 2 µM(AC50)
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| In vitro(体外研究) |
AKOS037652256 (Compound 8) (0.1-3 μM) was sufficient to induce TFEB-nuclear translocation (nuclear to cytosol ratio increased in a dose-dependent manner.[2]
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