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美索巴莫

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美索巴莫

货号：
IM2700

品牌：
Jinpan

美索巴莫

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产品简介
有效期 2年
MDL MFCD00057662
EC EINECS 208-524-3
InChIKey GNXFOGHNGIVQEH-UHFFFAOYSA-N
InChI InChI=1S/C11H15NO5/c1-15-9-4-2-3-5-10(9)16-6-8(13)7-17-11(12)14/h2-5,8,13H,6-7H2,1H3,(H2,12,14)
PubChem CID 4107
别名 甲氧卡巴莫；舒筋灵
英文名称 Methocarbamol
CAS 532-03-6
分子式 C11H15NO5
分子量 241.24
储存条件 2-8℃
纯度 ≥98%
外观（性状） White to off-white Powder
单位 瓶
生物活性 Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel. Methocarbamol reversibly affects voltage dependence of inactivation of Nav1.4 channel. Methocarbamol has the potential for muscle spasms and pain syndromes research[1-3].
In Vitro Methocarbamol (2?mM; for 20?min) significantly increases the decay times of the EPCs and those of the EPPs induced by the phrenic nerve stimulation[3].
In Vivo Neuromuscular transmission was investigated in murine diaphragm-phrenic nerve preparations and muscle force studied on mouse soleus muscles. Methocarbamol, at 2 mM, decreased the decay of endplate currents, slowed the decay of endplate potentials and reduced tetanic force of soleus muscles. The drug reversibly inhibited current flow through muscular Nav 1.4 channels.Muscular Na+ channels are a molecular target of methocarbamol. [3]
SMILES OC(COC1=CC=CC=C1OC)COC(N)=O
靶点 Carbonic Anhydrase，Sodium Channel(Nav1.4)
细胞实验 Methocarbamol (200?mg/kg; ip) has Muscle relaxant activity of 88.96%[3].
数据来源文献 [1]. Bruce, R.B., L.B. Turnbull, and J.H. Newman, Metabolism of methocarbamol in the rat, dog, and human. J Pharm Sci, 1971. 60(1): p. 104-6.
[2]. Sica, D.A., et al., Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol, 1990. 39(2): p. 193-4.
[3]. Yaxin Zhang, et al. Methocarbamol blocks muscular Na v 1.4 channels and decreases isometric force of mouse muscles. Muscle Nerve. 2020 Oct 11.
规格 50mg 100mg 250mg 500mg

是碳酸酐酶抑制剂，还可以可逆地影响电压依赖性的 Nav1.4 通道失活。具有用于肌肉痉挛和疼痛综合症研究的潜力。