标签归档：白三烯

白三烯B4酶免检测试剂盒(Leukotriene B4 EIA Kit)

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白三烯B4酶免检测试剂盒(Leukotriene B4 EIA Kit)

花生四烯酸是细胞膜的主要组分之一, 通过环氧合酶(cyclooxygenase, COX)和 脂 氧 合 酶 (lipoxygenase, LOX)途 径分别产生以前列腺素E2(prostaglandin E2, PGE2)和白三烯B4(leukotriene B4, LTB4)为代表的类花生酸类物质。LTB4由响应炎症介质的白细胞产生, 并活化多种白细胞功能, 包括白细胞聚集、离子流活化、增强溶酶体中酶的释放、超氧阴离子的产生、趋化等。白细胞活化后,血浆中LTB4的水平从<100pg>100ng/ml。LTB4在白细胞和肝细胞中代谢为20-羟基LTB4和20-羧基LTB4, 不排泄在尿液。

产品列表

品牌 产品名称 产品货号 规格
Cayman Leukotriene B4 ELISA Kit 520111-480 solid wells 480 solid wells
Cayman Leukotriene B4 ELISA Kit 520111-480 strip wells 480 strip wells
Cayman Leukotriene B4 ELISA Kit 520111-96 solid wells 96 solid wells
Cayman Leukotriene B4 ELISA Kit 520111-96 strip wells 96 strip wells
Cayman Leukotriene B4 Express ELISA Kit 10009292-480 solid wells 480 solid wells
Cayman Leukotriene B4 Express ELISA Kit 10009292-480 strip wells 480 strip wells
Cayman Leukotriene B4 Express ELISA Kit 10009292-96 solid wells 96 solid wells
Cayman Leukotriene B4 Express ELISA Kit 10009292-96 strip wells 96 strip wells

更多详情请咨询Cayman代理商-上海金畔生物

半胱氨酰白三烯 (Cysteinyl leukotrienes, CysLTs)检测试剂盒

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半胱氨酰白三烯 (Cysteinyl leukotrienes, CysLTs)检测试剂盒

半胱氨酰白三烯(Cysteinyl leukotrienes, CysLTs)是花生四烯酸经5-脂氧合酶催化途径生成的代谢产物。花生四烯酸经过5-脂氧合酶催化形成中间产物白三烯A4(LTA4), LTA4再经过两条代谢途径形成LTB4和LTC4, LTC4经酶解经一步转化为LTD4和LTE4。LTC4, LTD4, LTE4在第六位上均有半胱氨酸, 故称半胱氨酰白三烯。CysLTs参与哮踹、过敏性皮炎、心血管疾病、癌症、脑损伤及脑重构等过程。

相关产品：

产品名称
 货号 灵敏度 规格
Cysteinyl leukotriene EIA Kit 500390

50% B/B0: 103pg/ml

80% B/B0: 34pg/m

480 solid wells/480 strip wells

96 solid wells/96 strip wells
Cysteinyl leukotriene Express EIA Kit 10009291

50% B/B0: 80pg/ml

80% B/B0: 20pg/ml

480 solid wells/480 strip wells

96 solid wells/96 strip wells

Leukotriene C4 

EIA Kit

 520211 50% B/B0: 45pg/ml

80% B/B0: 10pg/ml

 /

Leukotriene E4 

EIA Kit

 520411 50% B/B0: 100pg/ml

80% B/B0: 25pg/ml

 /

更多详情请咨询Cayman代理商-上海金畔生物

半胱氨酰白三烯对脑的致损伤作用

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半胱氨酰白三烯对脑的致损伤作用

目前认为 , 各种脑损伤 ( 脑缺氧、脑外伤 ) 的继发性损伤或称二次脑损伤 (secondary injury) 因素是造成脑损害发生、发展的重要原因。

这些因素涉及：脑缺氧、钙离子超载、氧自由基堆积、炎性因子的刺激等。其中炎症应答 (inflammatory response) 是脑损伤病理生理过程中的一个重要组成环节，半胱氨酰白三烯 (cysteinyl LTs) 包括LTC4, LTD4 和 LTE4 是一类重要的炎症反应介质 , 是花生四烯酸 5-脂氧合酶 (5-lipoxygenase,5-LOX) 的代谢产物。 CysLTs 通过激活半胱氨酰白三烯受体 ( 包括 CysLT1 和 CysLT2 受体 ), 参与多种炎症病理过程 , 介导平滑肌痉挛 (smooth muscle constriction) 、微血管渗漏 (vascular leak) 等。近年研究证明 , CysLTs 除在哮喘、过敏性鼻炎等炎症性疾病发病过程中起重要作用外 , 也参与脑卒中、脑外伤、脑肿瘤、癫痫等中枢神经系统疾病的病理生理过程。脑缺血后CysLTs 释放增加 , 5-LOX 抑制剂能减少 CysLTs 的产生，从而保护脑缺血性损伤。

相关产品如下：

产品名称 货号 规格 供应商
A-803467 10012588 5/10/50/100mg Cayman
N-Ac-Tyr-Val-Ala-Asp-CMK 10014 1/5/10/25mg Cayman
AFMK 10005254 1/5/10/50mg Cayman
Agomelatine 13203 5/10/50/100mg Cayman
AL 34662 10011546 1/5/10/50mg Cayman
AM251 71670 5/10/50/100mg Cayman
AM404 90060 5/10/50/100mg Cayman
AM630 10006974 5/10/50/100mg Cayman
AM1172 10005223 1/5/10g/50mg Cayman
AM1241 10010118 1/5/10/25mg Cayman
(R)-AM1241 10491 1/5/10/25mg Cayman
(S)-AM1241 10490 1/5/10/25mg Cayman
AM3102 13452 5/10/25/50mg Cayman
N-Arachidonoyl-L-Alanine 90065 5/10/25/50mg Cayman
Arachidonoyl Amide 10007295 5/10/25/50mg Cayman
AMC Arachidonoyl Amide 10005098 5/10/25/50mg Cayman
7-Aminoclonazepam-d4* 10010670 1/5/10mg Cayman
β-Amyloid(1-8) Peptide 10241 1ea Cayman
β-Amyloid(1-8, A2V) Peptide 10229 1ea Cayman
Apelin-13 13523 1/5/10/25mg Cayman
N-(3-hydroxyphenyl)-Arachidonoyl Amide 10007704 5/10/50/100mg Cayman
产品名称 货号 规格 供应商
N-Arachidonoyl-γ-Aminobutyric Acid 90067 5/10/25/50mg Cayman
N-Arachidonoyl-3-hydroxy-γ-Aminobutyric Acid 10158 1/5/10/50 mg Cayman
Arachidonoyl 2’-Chloroethylamide 91054 5/10/50/100mg Cayman
Arachidonoyl Cyclopropylamide 91053 5/10/50/100mg Cayman
Arachidonoyl-N,N-dimethyl amide 10007293 5/10/50/100mg Cayman
N-Arachidonoyl Dopamine 90057 5/10/50/100mg Cayman
Arachidonoyl Ethanolamide 90050 5/10/50/100mg Cayman
oxy-Arachidonoyl Ethanolamide 10008642 5/10/25/50mg Cayman
Arachidonoyl Ethanolamide Phosphate 10180 250ug/500ug, 

1mg/5mg

 Cayman
O-Arachidonoyl Ethanolamine 91050 1/5/10/25mg Cayman
Arachidonoyl 2’-Fluoroethy-lamide 90054 5/10/50/100mg Cayman

(±)-2-Methyl Arachidonoyl-2’-Fluoroethylamide

 90055 1/5/10/25mg Cayman
Methyl Arachidonyl Fluorop-hosphonate 70660 1/5/10/25mg Cayman
Arachidonoyl-1-thio-Glycerol 10007904 1/5/10/25mg Cayman
1-Arachidonoyl Glycerol 62150 1/5/10/25mg Cayman
1-Arachidonoyl Glycerol-d5 362152 100ug/500ug

/1mg/5mg

 Cayman
2-Arachidonoyl Glycerol 62160 1/5/10/25mg Cayman
2-Arachidonoyl Glycerol-d5 362162

50ug/100ug

/500ug/1mg

 Cayman
2-Arachidonoyl Glycerol-d8 362160

25/50/100/500ug

 Cayman
O-Arachidonoyl Glycidol 10010547 5/10/50/100mg Cayman
Arachidonoyl Glycine 90051 5/10/50/100mg Cayman
Arachidonoyl-N-methyl amide 10007294 5/10/50/100mg Cayman
Arachidonoyl m-Nitroaniline 90059 5/10/25/50mg Cayman
Arachidonoyl Serinol 62170 5/10/50/100mg Cayman

更多产品详情，请联系Cayman代理商-上海金畔生物

白三烯B4(LTB4)检测试剂盒

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白三烯B4(LTB4)检测试剂盒

LTB4 ELISA kit    ADI-900-068    ADI-901-068

白三烯B4检测试剂盒

灵敏度：5.63 pg/ml

检测范围：11.7 – 3,000 pg/ml

样本类型：细胞培养上清，血浆，唾液和尿液

适用种属：无种属特异性

 

货号

产品名称

规格

灵敏度

中文名称

品牌

 ADI-900-068

 LTB4 ELISA kit

96 test

5.63 pg/ml

白三烯B4检测试剂盒

ENZO(美国)

 ADI-901-068

 LTB4 ELISA kit

5×96 wells

5.63 pg/ml

白三烯B4检测试剂盒

ENZO(美国)


文献引用

Adenine suppresses IgE-mediated mast cell activation: P. Silwal, et al.; Mol. Immunol. 65, 242 (2015), Application(s): ELISA -mast cells, Abstract;

Altered secretion of selected arachidonic acid metabolites during subclinical endometritis relative to estrous cycle stage and grade of fibrosis in mares: K. Gajos, et al.; Theriogenology (2015), Application(s): ELISA using mare sample, Abstract;

MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage: A.J. Lee, et al.; Exp. Mol. Med. 47, e00 (2015), Application(s): ELISA using macrophage incubations, Full Text

5-Lipoxygenase is a candidate target for therapeutic management of stem cell-like cells in acute myeloid leukemia: J. Roos, et al.; Cancer Res. 74, 5244 (2014), Application(s): EIA using mouse hematopoietic stem and progenitor cells (HSPC) supernatant, Abstract;

Clostridium difficile-induced colitis in mice is independent of leukotrienes: B.C. Trindade, et al.; Anaerobe 30, 90 (2014),Application(s): ELISA using cecal homogenates, Abstract;

Effect of a low-fat fish oil diet on proinflammatory eicosanoids and cell-cycle progression score in men undergoing radical prostatectomy: C. Gallet, et al.; Cancer Prev. Res. (Phila) 7, 97 (2014), Abstract;

Impact of wines and wine constituents on cyclooxygenase-1, cyclooxygenase-2, and 5-lipoxygenase catalytic activity: Z. Kutil, et al.; Mediators Inflamm. 2014, 178931 (2014), Application(s): ELISA using cell lysates, Abstract; Full Text

Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer’s disease mice: A. Di Meco, et al.; Neuobiol. Aging 35, 2458 (2014), Application(s): ELISA using brain homogenates, Abstract;

A highly sensitive and selective method for the determination of leukotriene B4 (LTB4) in ex vivo stimulated human plasma by ultra fast liquid chromatography-tandem mass spectrometry: W. Lin, et al.; J. Chromatogr B. analyt. Technol. Biomed. Life Sci.925, 54 (2013), Application(s): ELISA using plasma samples, Abstract;