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产品名称：
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美国wheaton224741样品瓶 |
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产品型号：
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224741 |
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产品特点 |
| 由WHEATON 33 硼硅酸盐玻璃制造，符合ASTM TYPE Ⅰ Class A和USP TYPE Ⅰ标准。带有单层PTFE膜胶垫酚醛塑料瓶盖*，适用于盛装和保存各种样品，有无色和棕色瓶。透明，透明，容量:2ml，12×38mm |
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产品详细信息： |
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由WHEATON 33 硼硅酸盐玻璃制造，符合ASTM TYPE Ⅰ Class A和USP TYPE Ⅰ标准。带有单层PTFE膜胶垫酚醛塑料瓶盖*，适用于盛装和保存各种样品，有无色和棕色瓶。透明，透明，容量:2ml，12×38mm
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2019-nCoV S Protein RBD
| 基因名 | SARS-CoV-2 (2019-nCoV) Spike ACE2 RBD-His Recombinant Protein |
| 别称 | 2019nCoVR S1 Protein RBD, 2019 SARS-nCov-2 S1 Protein RBD, 2019-nCoV S1 Protein RBD, SARS-CoV-2 S1 Protein RBD |
| 中文名称 | 新冠病毒S1蛋白RBD受体结合区 |
| Uniprot | P0DTC2 |
| 交叉反应(推测) | Human SARS2 |
| 氨基酸大小 | 25kDa |
| 表达氨基酸 | Recombinant protein is produced by our E.coli expression system and the target gene encoding Arg319-Phe542 is expressed with a 6His tag at the C-terminus. |
| Application | Immunology research |
| Derived from | E.coli |
| Purification | NI-NTA affinity purification |
| Formulation | (Liquid) Lyophilized from a 0.2 um filtered solution of PBS, PH 7.4. |
| Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage | Reconstituted protein solution should be stored at < -20°C for at least 12 months, though stable at 4-7°C for 1-2 month. |
| Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Purity | Purity≥90% |
| GeneID | 43740568 |
| 规格 | 10ug 50ug 100ug 1mg |
MiniH100加热款mini金属浴（标配酶标八连杯模块）
| 单位 | 台 |
| 规格 | MiniH100 8连杯 |
产品编号：
市场价：￥0.00元
会员价：￥0.00元
品牌：EPPENDORF 艾本德
生产厂家：eppendorf 艾本德
我们已经进入了悬浮细胞显微操作的新时代。新型Transfer- Man NK 2集简便性和革新性于一体，能满足最挑剔的用户的要求。
由于其改进了的比例化移动方式和菜单驱动，新型Transfer- Man NK 2融合了自动化处理和操作直观的操作特点，可以快速、简单、精确地完成复杂的显微操作。
| 控制： | 通过中央摇杆，比例化动态控制 |
| 动力： | 步进马达 |
| 分辨率： | 约每步40 nm |
| 最大位移(各轴)： | 约20 mm |
| 最大速度: | 7,500 µm/s |
| 大小（长X 宽X 高）： | |
| Y/Z 模块 | 12.0 x 10.0 x 6.8 cm |
| X 模块 | 12.0 x 6.0 x 5.0 cm |
| 控制面板 | 27.0 x 20.5 x 16.0 cm |
| 重量： | |
| 模块单元 | 1.4 kg |
| 带电源的全套控制面板 | 2.7 kg |
【简单介绍】
【详细说明】
【简单介绍】
【详细说明】
楤木
| 英文名称 | Radix Et Cortex Araliae |
| 储存条件 | 2-8℃ |
| 单位 | 瓶 |
| 规格 | 2g |
崩溃酶,Driselase® Basidiomycetes sp.,CAS：85186-71-6,货号：C8100-5g
| 市场价： | ￥6000.0 | |
| 价格： |
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| 品牌： | solarbio | |
| 规格： | 5g |
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产品详情
说明书下载
参考文献
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上海金畔生物科技有限公司是Viagenbiotech品牌代理商 ，欢迎访问官网了解更多产品信息和订购。
Viagenbiotech
ViaGen生物技术DirectPCR裂解试剂是一条完整的生产线用于快速、方便、可靠地从小鼠尾巴、耳朵、卵黄囊和培养细胞中提取DNA。
ViaGen生物技术DirectPCR裂解试剂是一条完整的生产线用于快速、方便、可靠地从小鼠尾巴、耳朵、卵黄囊和培养细胞中提取DNA。
Viagen Biotech Inc. is a leading provider of innovative DNA extraction technologies and products for life science research. Viagen DirectPCR® DNA Extraction System is a single-tube system for rapid preparation of DNA from mouse tails, ear pieces, yolk sac, and culture cells. The patent-pending components developed by scientists at Viagen Biotech Inc. allow the resulting DNA extracts to be compatible with genomic PCR for genotyping. Crude extracts of biological samples are not compatible with many molecular biology-grade reactions such as polymerase chain reaction (PCR), in part due to inhibitors contained in crude extracts. The DirectPCR reagents not only mediate the rapid lysis of biological samples but also contain inhibitors that effectively suppress the inhibitory activities of crude lysates for PCR amplification, while maximally maintaining the integrity of released genomic DNA. The procedure completely eliminates any solution transfer or tube-opening steps, saving a substantial amount of time and effort. DirectPCR reagents cost only 26 cents per tail, providing savings at any usage volume.
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品牌 |
货号 |
名称 |
规格 |
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Viagenbiotech |
501-PK |
Genomic PCR Grade Proteinase K Solution |
5ml |
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Viagenbiotech |
101-T |
DirectPCR Lysis Reagent (Mouse Tail) 50ml |
50ml |
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Viagenbiotech |
102-T |
DirectPCR Lysis Reagent (Mouse Tail) 100ml |
100ml |
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Viagenbiotech |
201-Y |
DirectPCR Lysis Reagent (Yolk Sac) 50 ml |
50ml |
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Viagenbiotech |
202-Y |
DirectPCR Lysis Reagent (Yolk Sac) 100 ml |
100ml |
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Viagenbiotech |
301-C |
DirectPCR Lysis Reagent (Cell) 50 ml |
50ml |
Abiraterone；阿比特龙
| MDL | MFCD00924100 |
| EC | EINECS 810-941-6 |
| 别名 | 坦度酮罗;阿比特伦 |
| 英文名称 | Abiraterone |
| CAS | 154229-19-3 |
| 分子式 | C24H31NO |
| 分子量 | 349.51 |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| 生物活性 | Abiraterone 是一种有效的选择性的不可逆 CYP17 抑制剂, IC50 为 2 到 4 nM[1]。 |
| IC50 | IC50: 2 to 4 nM (CYP17) [1] |
| In Vitro | 用阿齐拉酮≥5μM剂量显着抑制AR阳性前列腺癌细胞系LNCaP和VCaP的增殖[2]。对于17, 20-裂解酶和17α-羟化酶, 阿比特龙显示15nM和2.5nM的IC 50值 (CYP17是具有17α-羟化酶和17, 20-裂解酶活性的双功能酶) 。阿比特龙抑制人17, 20-裂解酶和17α-羟化酶, IC50分别为27和30 nM [3]。阿比特龙抑制重组人3βHSD1和3βHSD2活性, 竞争性Ki值为2.1和8.8μM。 10μM阿比特龙足以完全阻断两种细胞系中5α-二酮和DHT的合成。用强烈生长的亚组显着抑制CR1进展, 有效地在治疗4周内对肿瘤生长进行了上限 (P <0.00001) 。 LNCaP中阿比特龙抑制[3H] – 脱氢表雄酮 (DHEA) 消耗和Δ4-雄烯二酮 (AD) 积累, IC50 <1μM[4]。 |
| In Vivo | 先前显示0.5mmol / kg / d阿比特龙治疗剂量产生约0.5至1μM的血清浓度。对照组的异种移植肿瘤生长变化很大, 一些肿瘤生长缓慢, 只有一部分肿瘤表现出强劲的生长[4]。静脉内给药 (5mg / kg) 后, 清除率 (Cl) 和分布容积 (Vd) 分别为31.2mL / min / kg和1.97L / kg。发现AUC0-∞ (从零时间到无限时间点的血浆浓度 – 时间曲线下面积) 为2675ng * h / mL。终端半衰期 (t1 / 2) 为0.73小时。由于高清除率, 阿比特龙 (ART) 仅在静脉内给药后2小时才能量化[5]。 |
| SMILES | C[C@@]12C(C3=CN=CC=C3)=CC[C@]1([C@@]4(CC=C5[C@@](C)([C@]4(CC2)[H])CC[C@@H](C5)O)[H])[H] |
| 靶点 | Cytochrome P450 |
| 动物实验 | 小鼠[4]通过手术切除睾丸切除6-8周龄的雄性NOD / SCID小鼠并植入5mg 90天持续释放DHEA小丸以模拟具有人肾上腺生理学的CRPC。两天后, 用Matrigel皮下注射7×106个LAPC4细胞。肿瘤尺寸每周测量2至3次, 体积计算为长×宽×高×0.52。一旦肿瘤达到300mm 3, 将小鼠随机分配到载体或阿比特龙治疗组。阿比特龙组小鼠用5 mL / kg腹腔注射0.5 mmol / kg / d (0.1 mL 5％苄醇和95％红花油溶液) 和对照小鼠仅用载体治疗, 每日一次, 每周5天以上持续4周 (每次治疗n = 8只小鼠) 。基于混合效应模型, 通过ANOVA评估阿比特龙和媒介物治疗组之间的统计学显着性。大鼠[5]使用雄性Sprague-Dawley大鼠 (n = 8, 240-260g) 。在静脉注射5mg / kg剂量的ART后, 将血液样品 (450μL) 加入含有Na2-EDTA溶液作为抗凝剂的聚丙烯管中, 并在给药前给药, 0.12, 0.25, 0.5, 1, 2, 4, 6, 8 24小时 (在血液采集期间采用稀疏采样方案, 并且在每个时间点从四只动物采集血液) 。通过使用Biofuge在1760g离心血液5分钟来收获血浆, 并在-80±10℃下冷冻储存直至分析。 |
| 细胞实验 | 将LNCaP和VCaP细胞接种在96孔板中, 并在补充CSS的无酚红或FBS补充的培养基中生长7天。在接种后24和96小时, 用阿比特龙 (5μM和10μM) 处理细胞, 并通过添加CellTiter Glo并测量发光在第7天测定细胞活力[2]。 |
| 数据来源文献 | [1]. Attard G, et al. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J Clin Oncol. 2008 Oct 1; 26 (28) :4563-71.
[2]. Richards J, et al. Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100. Cancer Res. 2012 May 1; 72 (9) :2176-82. [3]. Stein MN, et al. Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer. Asian J Androl. 2014 May-Jun; 16 (3) :387-400. [4]. Li R, et al. Abiraterone inhibits 3β-hydroxysteroid dehydrogenase: a rationale for increasing drug exposure in castration-resistant prostate cancer. Clin Cancer Res. 2012 Jul 1; 18 (13) :3571-9. [5]. Kumar SV, et al. Validated RP-HPLC/UV method for the quantitation of abiraterone in rat plasma and its application to a pharmacokinetic study in rats. Biomed Chromatogr. 2013 Feb; 27 (2) :203-7. |
| 备注 | 以上数据均来自公开文献, Jinpan暂未进行独立验证, 仅供参考。These protocols are for reference only. Jinpan does not independently validate these methods. |
| 规格 | 50mg 100mg |
Abiraterone 是一种有效的选择性的不可逆 CYP17 抑制剂。