Abietic Acid；松香酸
货号：
IA1450
品牌：
Jinpan
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产品简介
| MDL | MFCD03423567 |
| EC | EINECS 208-178-3 |
| InChIKey | RSWGJHLUYNHPMX-ONCXSQPRSA-N |
| InChI | InChI=1S/C20H30O2/c1-13(2)14-6-8-16-15(12-14)7-9-17-19(16,3)10-5-11-20(17,4)18(21)22/h7,12-13,16-17H,5-6,8-11H2,1-4H3,(H,21,22)/t16-,17+,19+,20+/m0/s1 |
| PubChem CID | 10569 |
| 别名 | 树脂酸;松脂酸;simonellite |
| 英文名称 | Abietic Acid |
| CAS | 514-10-3 |
| 分子式 | C20H30O2 |
| 分子量 | 302.45 |
| 纯度 | HPLC≥98% |
| 单位 | 支 |
| 生物活性 | Abietic acid (Sylvic acid, Abietate, Rosin Acid), an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5?±?1.29?μM.[1-2] |
| In Vitro | Abietic acid has anti-inflammatory effects by inhibiting expression of genes involved in inflammation such as those for tumor necrosis factor-a and cyclooxygenase 2 in lipopolysaccharide-induced macrophages. Abietic acid regulates PPARγ target gene expression in RAW 264.7 macrophages and 3T3L adipocytes. It can be used for regulating lipid metabolism and atherosclelosis[2]. Abietic acid is a PPARγ ligand and that its anti-in￡ammatory effect is partly due to the activation of PPARγ in stimulated macrophages. In lipopolysaccharide (LPS)-stimulated macrophages, abietic acid suppresses production of prostaglandin E2 (PGE2) in vitro and in vivo[1]. |
| In Vivo | Abietic acid has an antiobesity effect in mice mediated by the regulation of adipogenesis[2]. |
| SMILES | C[C@@]1(C2[C@@](CCC1)(C)[C@@]3([H])CCC(C(C)C)=CC3=CC2)C(O)=O |
| 靶点 | 5-lipoxygenase��5-LOX�� |
| 动物实验 | pM-hPPARγ, p4xUASg-tk-luc, pCMX-CBP and pRL-CMV are transfected into CV1 cells and then, 24 h after the transfection, the cells are treated with abietic acid at various concentrations for 24 h.[3] |
| 细胞实验 | Animal Models: Male C57BL/6J mice; Dosages: 20 mg/kg and 40 mg/kg; Administration: oral administration[2] |
| 数据来源文献 | [1] Ulusu NN, et al. Phytother Res. 2002, 16(1):88-90. [2] Hwang KH, et al. J Med Food. 2011, 14(9):1052-6. [3] Takahashi N, et al. FEBS Lett. 2003, 550(1-3):190-4. |
| 规格 | 5mg 10mM*1mL in DMSO 10mg 20mg |
是一种三环二萜类含氧化合物，是最重要的树脂酸之一。