Atazanavir sulfate/BMS-232632 sulfate；硫酸阿扎那韦
货号：
IA1930
品牌：
Jinpan
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产品简介
| MDL | MFCD08067748 |
| EC | EINECS 620-495-2 |
| 别名 | 西洛司特;阿扎那韦硫酸盐;AtazanavirBisulfateSalt |
| 英文名称 | Atazanavir sulfate/BMS-232632 sulfate |
| CAS | 229975-97-7 |
| 分子式 | C38H52N6O7·H2SO4 |
| 分子量 | 802.93 |
| 纯度 | HPLC≥99% |
| 单位 | 瓶 |
| 生物活性 | BMS-232632 is an azapeptide human immunodeficiency virus type 1 (HIV-1) protease (Prt) inhibitor that exhibits potent anti-HIV activity with a 50% effective concentration (EC(50)) of 2.6 to 5.3 nM and an EC(90) of 9 to 15 nM in cell culture. [1] |
| In Vitro | BMS-232632 blocks the cleavage of viral precursor proteins in HIV-infected cells, proving that it functions as an HIV Prt inhibitor. Comparative studies showed that BMS-232632 is generally more potent than the five currently approved HIV-1 Prt inhibitors. Furthermore, BMS-232632 is highly selective for HIV-1 Prt and exhibits cytotoxicity only at concentrations 6,500- to 23, 000-fold higher than that required for anti-HIV activity. [1] |
| SMILES | O=C(OC)N[C@@H](C(C)(C)C)C(NN(CC1=CC=C(C2=NC=CC=C2)C=C1)C[C@H](O)[C@H](CC3=CC=CC=C3)NC([C@H](C(C)(C)C)NC(OC)=O)=O)=O.O=S(O)(O)=O |
| 靶点 | HIV |
| 数据来源文献 | [1] Robinson BS, et al. Antimicrob Agents Chemother, 2000, 44(8), 2093-2099. |
| 规格 | 10mg 50mg 100mg |
是HIV-1蛋白酶高活性抑制剂。