阿莫奈韦
货号：
IA4260
品牌：
Jinpan
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产品简介
| 别名 | ASP-2151 |
| 英文名称 | Amenamevir |
| CAS | 841301-32-4 |
| 分子式 | C24H26N4O5S |
| 分子量 | 482.55 |
| 储存条件 | -20度 |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| 生物活性 | Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.[1] |
| In Vitro | ASP2151 inhibited the in vitro replication of HSV-1. The mean EC50s of ASP2151 against HSV-1 and HSV-2 were 14 (range, 7.7 to 20) and 30 ng/ml (range, 15 to 58), respectively[2]. |
| In Vivo | In the cutaneously HSV-1-infected mouse model, ASP2151 dose dependently suppressed intradermal HSV-1 growth, with the effect reaching a plateau at a dose of 30 mg/kg of body weight/day[2]. |
| SMILES | O=C(C(CC1)CCS1(=O)=O)N(C2=C(C)C=CC=C2C)CC(NC3=CC=C(C4=NOC=N4)C=C3)=O |
| 靶点 | DNA/RNA Synthesis inhibitor |
| 细胞实验 | Animal Models: HSV-1-infected mice; Dosages: 1, 3, 10, 30, or 100 mg/kg/day; Administration: oral[2] |
| 数据来源文献 | [1] Kawashima M, et al. J Dermatol. 2017, 44(11):1219-1227. [2] Katsumata K, et al. Antimicrob Agents Chemother. 2013, 57(3):1339-46. |
| 规格 | 5mg |
是一种HSV（单纯疱疹病毒）解旋酶-引发酶抑制剂，对HSV具有强抗病毒活性