环索奈德
货号：
IC2720
品牌：
Jinpan
暂无详情
暂无详情
产品简介
| 有效期 | 2年 |
| 别名 | RPR-251526 |
| 英文名称 | Ciclesonide |
| CAS | 126544-47-6 |
| 分子式 | C32H44O7 |
| 分子量 | 540.69 |
| 储存条件 | -20℃ |
| 纯度 | ≥98% |
| 外观（性状） | Solid |
| 单位 | 瓶 |
| In Vitro | Ciclesonide, the parent compound, undergoes hydrolysis by ester cleavage at the C21 position to the active metabolite, desisobutyryl-ciclesonide (des-CIC), followed by reversible formation of fatty acid esters within the lung cells. Ciclesonide (5 μM) is rapidly hydrolyzed by normal human bronchial epithelial (NHBE) cells (approximately 30% conversion at 4h), with almost complete conversion by 24 h[1]. |
| SMILES | O=C([C@]([C@@]1([H])C[C@@]2([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(C=C4)C)([H])[C@@H](O)C5)(O[C@H](C6CCCCC6)O1)[C@]25C)COC(C(C)C)=O |
| 靶点 | Glucocorticoid Receptor |
| 数据来源文献 | [1]. Mutch, E., et al., The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue. Biochem Pharmacol, 2007. 73(10): p. 1657-64. |
| 规格 | 5mg 10mg |
是一种具有强效抗炎活性的糖皮质激素，可用于阻塞性气道疾病的相关研究。