对甲基托莫西汀盐酸盐
货号：
IA4810
品牌：
Jinpan
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产品简介
| 有效期 | 2年 |
| EC | EINECS 200-659-6 |
| MDL | MFCD06410992 |
| InChIKey | LUCXVPAZUDVVBT-UNTBIKODSA-N |
| InChI | InChI=1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1 |
| PubChem CID | 54840 |
| 别名 | 盐酸托莫西汀 |
| 英文名称 | Atomoxetine Hydrochloride |
| CAS | 82248-59-7 |
| 分子式 | C17H22ClNO |
| 分子量 | 291.82 |
| 储存条件 | -20℃ |
| 纯度 | ≥98% |
| 外观（性状） | White to off-white Powder |
| 单位 | 瓶 |
| 生物活性 | Atomoxetine是一种选择性去甲肾上腺素重摄取抑制剂，Ki 为5 nM，而与5-羟色胺和多巴胺转运蛋白结合的Ki为77和1451 nM。[1] |
| In Vitro | The selective norepinephrine (NE) transporter inhibitor atomoxetine (formerly called tomoxetine or LY139603) has been shown to alleviate symptoms in Attention Deficit/Hyperactivity Disorder (ADHD). Atomoxetine inhibited binding of radioligands to clonal cell lines transfected with human NE, serotonin (5-HT) and dopamine (DA) transporters with dissociation constants (K(i)) values of 5, 77 and 1451 nM, respectively, demonstrating selectivity for NE transporters.[1] |
| In Vivo | Tomoxetine (LY139603) selectively inhibits norepinephrine uptake in animals and has activity in animal models of depression. [2]In microdialysis studies, atomoxetine increased extracellular (EX) levels of NE in prefrontal cortex (PFC) 3-fold, but did not alter 5-HT(EX) levels. Atomoxetine also increased DA(EX) concentrations in PFC 3-fold, but did not alter DA(EX) in striatum or nucleus accumbens.[1] |
| SMILES | [C@H](OC1=C(C=CC=C1)C)(C2=CC=CC=C2)CCNC.[H+].[Cl-] |
| 靶点 | Others |
| 数据来源文献 | [1] Bymaster FP, et al. Neuropsychopharmacology, 2002, 27(5), 699-711.[ 2] Zerbe RL, et al. J Pharmacol Exp Ther, 1985, 232(1), 139-143. |
| 规格 | 100mg 250mg |
是一种选择性的去甲肾上腺素(NE)转运体抑制剂。