Vitexin；牡荆素
货号：
IV0150
品牌：
Jinpan
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产品简介
| MDL | MFCD00017456 |
| EC | EINECS 222-963-8 |
| 别名 | 芹菜甙元-8-O-葡萄糖甙;牡荆苷 |
| CAS | 3681-93-4 |
| 分子式 | C21H20O10 |
| 分子量 | 432.38 |
| 纯度 | HPLC≥98% |
| 生物活性 | Vitexin (Apigenin-8-C-glucoside), an naturally occuring apigenin flavone glycoside, acts as a platelet aggregation and alpha-glucosidase inhibitor and shows antineoplastic activity.[1-2] |
| In Vitro | Vitexin promotes cell viability, inhibits apoptosis, and decreases inflammatory cytokines. These protective effects are related to the regulation of ER stress by vitexin in chondrocytes[2]. |
| In Vivo | Vitexin ameliorates sexual dysfunction and fertility impairments in male diabetic mice possibly by modulating the hypothalamus-pituitary-gonadal axis[1]. |
| SMILES | OC1=CC=C(C2=CC(C(C(O)=CC(O)=C3[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)=C3O2)=O)C=C1 |
| 靶点 | Others |
| 动物实验 | Animal Models: adult male mice (25–30?g); Dosages: 10, 20 and 40 mg/kg; Administration: oral[1] |
| 细胞实验 | Chondrocytes (2 × 105 cells) were planted in a 96-well plate and treated with various doses of vitexin, with or without IL-1β (10 ng/mL), for 1 day according to the requirements of the experiment. All of the chondrocytes were incubated for 2 h with cholecystokinin octapeptide (CCK-8) (10 μL) and the absorbance of the reaction at 450 nm was then quantified using a micro-plate reader.[2] |
| 数据来源文献 | [1] Li ZM, et al. Chem Biol Interact. 2018, 297:119-129. [2] Xie CL, et al. Food Funct. 2018, doi: 10.1039/c8fo01509k. |
| 规格 | 5mg 20mg |
Vitexin 是一种 c-糖基化的黄酮，存在于多种药用植物中。