AZD-0156
货号：
IA3860
品牌：
Jinpan
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产品简介
| 别名 | CID118502708 |
| CAS | 1821428-35-6 |
| 分子式 | C26H31N5O3 |
| 分子量 | 461.56 |
| 储存条件 | -20℃ |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| 生物活性 | AZD0156 是有效的、选择性的ATM激酶抑制剂，具有潜在的化疗/辐射增敏和抗肿瘤活性。AZD0156 可防止DNA损伤检查点激活，破坏DNA损伤修复，诱导肿瘤细胞凋亡，并导致过表达ATM的肿瘤细胞死亡。[1] |
| In Vitro | AZD0156 shows sub-nanomolar potency in cell based assays of ATM inhibition with selectivities of greater than 1000 fold over other members of the PIKK family of enzymes. [1] |
| In Vivo | AZD0156 is a permeable, highly soluble compound with excellent preclinical pharmacokinetic properties including oral bioavailability. AZD0156 shows robust efficacy in mouse xenograft models after oral administration when combined with DSB inducing agents. [1] |
| SMILES | O=C(N1C2CCOCC2)N(C)C3=C1C4=CC(C5=CC=C(OCCCN(C)C)N=C5)=CC=C4N=C3 |
| 靶点 | ATM/ATR |
| 数据来源文献 | [1] Kurt G. Pike. Cancer Res. 2016, 76(14 Suppl):Abstract nr 485 |
| 规格 | 5mg |
AZD0156是有效的、选择性的ATM激酶抑制剂