Dectin-1 激动剂及相关产品推荐
Dectin-1是C型凝集素受体(CLR)家族成员之一，在抗真菌天然免疫反应中发挥重要作用。Dectin-1是β-glucan(β-葡聚糖)的特异性跨膜受体。β-glucan，即葡萄糖聚合物，则是真菌(包括酿酒酵母Saccharomyces cerevisiae和白色念珠球菌Candida albican)细胞壁的主要成分。与其受体结合后，Dectin-1会引起细胞胞吞作用，并通过Syk激酶和接头分子CARD9/Bcl10/Malt1传递信号，进而诱导活性氧ROS的产生、NF-κB的活化及后续炎症因子的产生。Dectin-1和TLR2可协同发挥作用来增强各自的信号级联反应。
相关产品推荐：
|
PRODUCT |
ORIGIN/DESCRIPTION |
GRADE* |
WORKING CONCENTRATION |
QTY |
CATALOG CODE |
|
Dectin-1 Agonists |
|||||
|
Beta-Glucan Peptide |
Beta-glucan from Trametes versicolor |
TLR2 -/ TLR4 – |
1 – 100 µg/ml |
50 mg |
tlrl-bgp |
|
Curdlan |
Beta-1,3-glucan from Alcaligenes faecalis |
TLR2 -/ TLR4 – |
100 µg/ml |
1 g |
tlrl-curd |
|
HKCA |
Heat-killed Candida albicans |
TLR2 -/ TLR4 – |
108 cells/ml |
109 cells |
tlrl-hkca |
|
Laminarin |
Soluble beta-glucan from Laminaria digitata |
TLR2 +/ TLR4 – |
1 – 100 µg/ml |
100 mg |
tlrl-lam |
|
Pustulan |
Beta-glucan from Lasallia pustulata |
TLR2 -/ TLR4 – |
1 – 100 µg/ml |
100 mg |
tlrl-pst |
|
Schizophyllan |
Beta-glucan from Schizophyllum commune |
TLR2 -/ TLR4 – |
1 – 100 µg/ml |
100 mg |
tlrl-spg |
|
PRODUCT |
ORIGIN/DESCRIPTION |
GRADE* |
WORKING CONCENTRATION |
QTY |
CATALOG CODE |
|
Dectin-1 Agonists |
|||||
|
Scleroglucan |
Beta-glucan from Sclerotium rolfsii |
TLR2 +/ TLR4 + |
1 – 100 µg/ml |
100 mg |
tlrl-scg |
|
WGP Dispersible |
Whole Glucan Particles, insoluble |
TLR2 -/ TLR4 – |
1 – 200 µg/ml |
50 mg |
tlrl-wgp |
|
WGP Soluble |
Whole Glucan Particles, soluble |
TLR2 -/ TLR4 – |
1 ng – 1 µg/ml |
50 mg |
tlrl-wgps |
|
Zymosan |
Cell wall preparation from S. cerevisiae |
TLR2 +/ TLR4 – |
1 – 10 µg/ml |
100 mg |
tlrl-zyn |
|
Zymosan Depleted |
Hot alkali treated zymosan |
TLR2 -/ TLR4 – |
100 µg/ml |
10 mg |
tlrl-zyd |
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