NOD1/2激动剂及相关产品

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NOD1/2激动剂及相关产品

NOD1(又称CARD4)和NOD2(又称CARD15)是能感知细菌肽聚糖(PGN)成份的细胞内模式识别受体。NOD1识别全部革兰氏阴性菌和部分革兰氏阳性菌PGN成份中的iE-DAP，而NOD2则识别差不多全部细菌都带有的MDP结构。iE-DAP和MDP成份必须通过细菌侵入细胞或其它细胞物质摄入方式进入到细胞后才能被识别。识别配体后，NOD1和NOD2形成多聚体，通过RIP2激酶的丝氨酸/酪氨酸来传递讯号。激活后的RIP2可泛素化修饰NEMO/IKK©，从而引起NF-kB的活化和炎症因子的释放。

NOD1/2激动剂相关产品：

PRODUCT

ORIGIN/DESCRIPTION

GRADE*

WORKING

CONCENTRATION

QTY

CATALOG

CODE

NOD1 Agonists

C12-iE-DAP

Acylated derivative of iE-DAP

TLR2 -/ TLR4 –

1 ng – 1 µg/ml

1 mg

tlrl-c12dap

C14-Tri-LAN-Gly                 NEW

Meso‑lanthionine tri-peptide (CL243)

TLR2 -/ TLR4 –

1 ng – 1 µg/ml

1 mg

tlrl-ctlg

iE-DAP

D-γ-Glu-mDAP

TLR2 -/ TLR4 –

1 – 100 µg/ml

5 mg

tlrl-dap

iE-Lys

iE-DAP negative control

TLR2 -/ TLR4 –

1 – 100 µg/ml

5 mg

tlrl-lys

Tri-DAP

L-Ala-γ-D-Glu-mDAP

TLR2 -/ TLR4 –

100 ng – 10 µg/ml

1 mg

tlrl-tdap

NOD2 Agonists

CL429

Pam2C-conjugated murabutide

TLR2 +/ TLR4 –

1 ng – 10 µg/ml

5 mg

tlrl-c429

CL429 VacciGrade™

TLR2/NOD2 agonist

VacciGrade™

20 -50 µg/mouse

5 mg

vac-c429

L18-MDP

Muramyldipeptide with a C18 fatty acid chain

TLR2 -/ TLR4 –

1 – 100 ng/ml

1 mg

tlrl-lmdp

MDP

Muramyldipeptide (L-D isoform, active)

TLR2 -/ TLR4 –

10 ng – 10 µg/ml

5 mg

tlrl-mdp

MDP control

Muramyldipeptide (D-D isoform, inactive)

TLR2 -/ TLR4 –

10 ng – 10 µg/ml

5 mg

tlrl-mdpc

M-TriLYS

Synthetic muramyl tripeptide

TLR2 -/ TLR4 –

100 ng – 10 µg/ml

1 mg

tlrl-mtl

Murabutide

Synthetic derivative of muramyldipeptide

TLR2 -/ TLR4 –

1 – 100 ng/ml

5 mg

tlrl-mbt

N-Glycolyl-MDP

N-glycolylated muramyldipeptide

TLR2 -/ TLR4 –

100 ng – 10 µg/ml

5 mg

tlrl-gmdp

NOD1/2 Agonists

M-TriDAP

MurNAc-L-Ala-γ-D-Glu-mDAP

TLR2 -/ TLR4 –

100 ng – 10 µg/ml

1 mg

tlrl-mtd

PGN-ECndi Ultrapure

Insoluble peptidoglycan from E. coli K12

TLR2 -/ TLR4 –

1 – 5 µg/ml

5 mg

tlrl-kipgn

PGN-ECndss Ultrapure

Soluble sonicated peptidoglycan from E. coli K12

TLR2 -/ TLR4 –

1 – 5 µg/ml

1 mg

tlrl-ksspgn

PGN-SAndi Ultrapure

Insoluble peptidoglycan from S. aureus

TLR2 -/ TLR4 –

1 – 5 µg/ml

5 mg

tlrl-sipgn