TLR4 激动剂及相关产品介绍
TLR4是革兰氏阴性菌脂多糖(LPS)和毒性成份lipid A的受体。TLR4与LPS的应答,除了受体本身,也需要另外3种不同的胞外蛋白:LBP(LPS结合蛋白)、CD14和MD-2(髓样分化蛋白2)才能发挥作用。TLR4介导的信号通路有两条:一条是MyD88依赖 的,另一条是MyD88非依赖的。MyD88依赖的信号通路导致AP-1和NF-kB等转录因子入核,促进一些炎症因子的释放;MyD88非依赖的信号通路可激活IRF3和另外一个接头分子TRAM(TRIF相关的接头蛋白),IRF3活化后可使细胞产生IFN-®️,上调一些干扰素依赖基因的表达。
TLR4激动剂相关产品:
PRODUCT |
ORIGIN/DESCRIPTION |
GRADE* |
WORKING CONCENTRATION |
QTY |
CATALOG CODE |
TLR4 Agonists |
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CRX-527 NEW |
Synthetic Lipid A analog |
TLR2 – /TLR4 + |
100 pg/ml – 10 ng/ml |
1 mg |
tlrl-crx527 |
LPS-B5 |
Standard lipopolysaccharide from E. coli 055:B5 |
TLR2 + /TLR4 + |
100 pg – 1 µg/ml |
5 mg |
tlrl-b5lps |
LPS-B5 Ultrapure |
Ultrapure lipopolysaccharide from E. coli 055:B5 |
TLR2 – /TLR4 + |
100 pg – 1 µg/ml |
5 mg |
tlrl-pb5lps |
LPS-EB |
Standard lipopolysaccharide from E. coli 0111:B4 |
TLR2 + /TLR4 + |
10 ng – 10 µg/ml |
5 mg |
tlrl-eblps |
LPS-EB Biotin |
Biotinylated ultrapure LPS from E. coli 0111:B4 |
TLR2 + /TLR4 + |
10 ng – 10 µg/ml |
500 µg |
tlrl-3blps |
LPS-EB Ultrapure |
Ultrapure lipopolysaccharide from E. coli 0111:B4 |
TLR2 – /TLR4 + |
10 ng – 10 µg/ml |
5×106 EU |
tlrl-3pelps |
LPS-EB VacciGrade™ |
Preclinical grade ultrapure LPS from E. coli 0111:B4 |
VacciGrade™ |
0.1 – 25 µg/mouse |
5×106 EU |
vac-3pelps |
LPS-EK |
Standard lipopolysaccharide from E. coli K12 |
TLR2 + /TLR4 + |
1 ng – 10 µg/ml |
5 mg |
tlrl-eklps |
LPS-EK Ultrapure |
Ultrapure lipopolysaccharide from E. coli K12 |
TLR2 – /TLR4 + |
1 ng – 10 µg/ml |
1 mg |
tlrl-peklps |
LPS-PG |
Standard lipopolysaccharide from P. gingivalis |
TLR2 + /TLR4 + |
100 ng – 10 µg/ml |
1 mg |
tlrl-pglps |
LPS-PG Ultrapure |
Ultrapure lipopolysaccharide from P. gingivalis |
TLR2 – /TLR4 + |
100 ng – 10 µg/ml |
1 mg |
tlrl-ppglps |
LPS-SM Ultrapure |
Ultrapure lipopolysaccharide from S. minnesota |
TLR2 – /TLR4 + |
10 ng – 10 µg/ml |
5 mg |
tlrl-smlps |
MPLA-SM |
Monophosphoryl lipid A from S. minnesota |
TLR2 – /TLR4 + |
10 ng – 1 µg/ml |
1 mg |
tlrl-mpla |
MPLA-SM VacciGrade™ |
Preclinical grade detoxified MPLA |
VacciGrade™ |
2 – 20 µg/mouse |
1 mg |
vac-mpla |
MPLA Synthetic |
Synthetic monophosphoryl lipid A |
TLR2 – /TLR4 + |
300 pg – 100 ng/ml |
1 mg |
tlrl-mpls |
MPLA Synthetic VacciGrade™ |
Preclinical grade synthetic MPLA |
VacciGrade™ |
2 – 20 µg/mouse |
1 mg |
vac-mpls |
TLR4 Antagonist |
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LPS-RS |
Lipopolysaccharide from Rhodobacter sphaeroides |
TLR2 + /TLR4 – |
10 ng – 10 µg/ml |
5 mg |
tlrl-rslps |
LPS-RS Ultrapure |
Ultrapure lipopolysaccharide from R. sphaeroides |
TLR2 – /TLR4 – |
10 ng – 10 µg/ml |
1 mg |
tlrl-prslps |
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