TLR3 激动剂(CD283)及相关产品介绍

TLR3 激动剂(CD283)及相关产品介绍

TLR3(又名CD283)是一个胞内受体,可识别与病毒感染相关的双链RNA(dsRNA)分子模式。其中一个TLR3的配体,Poly(I:C),是人工合成的dsRNA类似物。TLR3信号通路不依赖于MyD88,而是通过接头蛋白TRIF(包含TIR结构域的接头蛋白,可诱导IFN-β产生)发挥作用。IRF3(干扰素调节因子3)被磷酸化后导致IFN-β(β干扰素)产生,进一步活化ISRE(干扰素激活反应元件)。另外,TLR3信号通路的激活也可导致AP-1和NF-kB等转录因子入核,促进一些炎症因子的释放。

TLR3激动剂相关产品:

PRODUCT

ORIGIN/DESCRIPTION

GRADE*

WORKING

CONCENTRATION

QTY

CATALOG

CODE

TLR LIGANDS

TLR3 Agonists

Poly(A:U)

Polyadenylic-polyuridylic acid

TLR2 -/ TLR4 –

300 ng- 100 µg/ml

10 mg

tlrl-pau

Poly(I:C) (HMW)

Polyinosine-polycytidylic acid

High molecular weight (1.5-8 kb)

TLR2 -/ TLR4 –

30 ng – 10 µg/ml

10 mg

50 mg

tlrl-pic

tlrl-pic-5

Poly(I:C) (HMW) Biotin

Biotinylated poly(I:C) (HMW)

TLR2 -/ TLR4 –

30 ng – 10 µg/ml

10 µg

tlrl-picb

Poly(I:C) (HMW) Fluorescein

Fluorescein-labeled poly(I:C) (HMW)

TLR2 -/ TLR4 –

10 ng – 10 µg/ml

10 µg

tlrl-picf

Poly(I:C) (HMW) Rhodamine

Rhodamine-labeled poly(I:C) (HMW)

TLR2 -/ TLR4 –

10 ng – 10 µg/ml

10 µg

tlrl-picr

PRR Ligands

PRODUCT

ORIGIN/DESCRIPTION

GRADE*

WORKING

CONCENTRATION

QTY

CATALOG

CODE

TLR3 Agonists

Poly(I:C) (HMW) VacciGrade

Preclinical grade  poly(I:C) (HMW)

VacciGrade

10 µg – 100 µg/mouse

10 mg

vac-pic

Poly(I:C) (LMW)

Polyinosine-polycytidylic acid

Low molecular weight (0.2-1 kb)

TLR2 – /TLR4 –

30 ng – 10 µg/ml

25 mg

250 mg

tlrl-picw

tlrl-picw-250

Poly(I:C) (LMW) Rhodamine

Rhodamine-labeled poly(I:C) (LMW)

TLR2 – /TLR4 –

100 ng – 10 µg/ml

10 µg

tlrl-piwr

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