BioXCell热销产品—InVivoMAb anti-human Ganglioside GD2（货号：BE0318）
克隆号14G2a单克隆抗体与人神经节苷脂GD2反应，后者是一种含有唾液酸的糖脂，参与调节细胞与细胞外基质的附着。神经节苷脂GD2在神经外胚层起源的肿瘤上表达，包括人神经母细胞瘤和黑色素瘤。GD2的肿瘤特异性表达使其成为用单克隆抗体或人工T细胞受体进行免疫治疗的合适靶标。克隆号14G2a是选自亲本产生IgG3的杂交瘤14.18的同种型开关变体，并且具有与亲本抗体相同的反应性。
产品详情
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产品货号 |
BE0318 |
|
产品规格 |
1/5/25/50/100mg |
|
抗体亚型 |
Mouse IgG2a, κ |
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推荐同型对照 |
InVivoMAb mouse IgG2a isotype control, unknown specificity（货号：BE0085） |
|
推荐抗体稀释液 |
InVivoPure™ pH7.0 Dilution Buffer（货号：IP0070） |
|
免疫原 |
Neuroblastoma cell line LAN-1 |
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应用 |
in vitro induction of apoptosis in GD2+ cells in vivo inhibition of GD2+ tumor cell growth |
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产品形式 |
PBS , pH 7.0 Contains no stabilizers or preservatives |
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内毒素水平 |
<2eu> 使用 LAL gel clotting 测定 |
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纯度 |
>95% Determined by SDS-PAGE |
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无菌处理 |
0.2 μM filtered |
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生产形式 |
从组织培养上清液中纯化得到。 |
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纯化形式 |
Protein A |
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RRID |
AB_2819045 |
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分子量大小 |
150 kDa |
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保存条件 |
抗体原溶液应保存在4°C条件下，不要冷冻保存。 |
已发表参考文献：
|
in vitro induction of apoptosis in GD2+ cells |
Durbas, M., et al. (2018). “GD2 ganglioside-binding antibody 14G2a and specific aurora A kinase inhibitor MK-5108 induce autophagy in IMR-32 neuroblastoma cells.” Apoptosis 23(9-10): 492-511. |
|
in vitro induction of apoptosis in GD2+ cells |
Kowalczyk, A., et al. (2009). “The GD2-specific 14G2a monoclonal antibody induces apoptosis and enhances cytotoxicity of chemotherapeutic drugs in IMR-32 human neuroblastoma cells.” Cancer Lett 281(2): 171-182. |
|
in vivo induction of apoptosis in GD2+ cells |
Mujoo, K., et al. (1989). “Functional properties and effect on growth suppression of human neuroblastoma tumors by isotype switch variants of monoclonal antiganglioside GD2 antibody 14.18.” Cancer Res 49(11): 2857-2861. |
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