用于Omicron研究的抗体和重组蛋白
2021 年 11 月 26 日,WHO 将 SARS-CoV-2 变体 B.1.1.529 指定为第五种关注变体 (VOC),并将其命名为“Omicron”,在其基因组中的 50 多个突变中,至少有 32 个位于棘突蛋白,其中 RBD 有 15 个点突变(图 1);与其他 VOC 一样,在 Omicron 的核蛋白中也发现了突变(图 2);Omicron 分布广泛,胜过 Delta,尽管它似乎会导致更轻微的疾病,但它仍然导致住院人数增加。
图 1. Spike mutation sites found in Omicron are A67V, Δ69-70, T95I, G142D/Δ143-145, Δ211/L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493K, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F.
图 2. Nucleocapsid protein mutation sites found in Omicron are P13L, Δ31-33, R203M, G204R, and in Delta are D63G, R203M, G215C, D377Y.
GeneTex 提供一系列用于Omicron 研究的重组抗体和蛋白质试剂,值得注意的是,其免疫原不包含任何 Omicron 突变位点的棘蛋白和核蛋白抗体如图 2 所示。请参阅下面的精选产品列表以及表格所选抗体对VOC的反应性。
精选产品
SARS-CoV-2 (COVID-19) Spike RBD Protein, B.1.1.529 / Omicron variant, His tag (GTX136716-pro)
SARS-CoV-2 (COVID-19) nucleocapsid protein, B.1.1.529 / Omicron variant, His tag (GTX136779-pro)
SARS-CoV-2 (COVID-19) Spike (ECD) Protein, B.1.1.529 / Omicron variant, His tag (GTX136780-pro)
SARS-CoV-2 (COVID-19) Spike RBD antibody [HL257] (GTX635692)
SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1014] (GTX635807)
抗体对 |
产品名 |
EC50 |
目录号 |
Pair I | Nucleocapsid antibody [HL5511] | 14 pM | GTX635689 |
Pair I | Nucleocapsid antibody [HL448] | 11 pM | GTX635686 |
Pair II | Nucleocapsid antibody [HL5410] | 9 pM | GTX635685 |
Pair II | Nucleocapsid antibody [HL455] | 6 pM | GTX635688 |
产品名 |
表现系统 |
目录号 |
Spike (ECD) Protein, B.1.1.529 / Omicron variant, His tag | HEK293 | GTX136780-pro |
Spike RBD Protein, B.1.1.529 / Omicron variant, His tag | HEK293 | GTX136716-pro |
SARS-CoV-2 (COVID-19) nucleocapsid protein, B.1.1.529 / Omicron variant, His tag | HEK293 cells | GTX136779-pro |
SARS-CoV-2 VOCs
产品名 |
目录号 |
WIV04/2019 |
B.1.617.2 |
B.1.1.529 |
Spike RBD antibody [HL1014] | GTX635807 | ● | ● | ● |
Spike RBD antibody [HL1002] | GTX635791 | ● | ● | X |
Spike RBD antibody [HL1003] | GTX635792 | ● | ● | ● |
Spike RBD antibody [HL1004] | GTX635793 | ● | ● | ● |
Spike S1 antibody [HL13402] | GTX635713 | ● | ● | X |
Spike S1 antibody [GT263] | GTX635708 | X | 未检测 | X |
Spike antibody [1A9] | GTX632604 | ● | ● | ○ |
Spike S2 antibody [HL237] | GTX635693 | ○ | ● | ● |
详情请咨询Genetex代理商上海金畔生物科技有限公司