肠道菌群
人体内的细菌数量是人体细胞的10倍。这些微生物群广泛存在肠道上皮和粘膜细胞表面,对维持机体健康起着非常重要的作用。如果正常的共生微生物群(肠道菌群)的生态平衡发生紊乱,将严重影响人体健康,引发风湿性关节炎、炎症性肠病、多发性硬化症及糖尿病等多种疾病。除了能抵御有害病菌造成的物理及化学的伤害,肠道菌群在维持免疫功能(Th17,Treg及固有淋巴细胞)方面也发挥着重要的作用。
肠道免疫系统能区分共生菌和病原菌,对共生菌产生免疫耐受,而对病原菌及其他抗原物质产生免疫反应。Th17细胞是能产生IL-17的CD4+T淋巴细胞亚群,Th17的产生依赖于肠道共生菌的存在,并成为肠道免疫屏障的重要组成部分。它的适量存在有助于维持肠道免疫功能,而Th17的过度诱导则会导致肠道免疫功能破坏。此外,在肠道免疫系统中对共生菌耐受的CD4+CD25+Treg细胞及其产生的一致性细胞因子IL-10和TGF-β也发挥着重要作用,Th17细胞的分化发育又与Treg细胞分化发育呈抑制性关系。因此,Th17和Treg细胞是连接着肠道菌群和肠道免疫功能的关键细胞亚群。
肠道免疫系统能区分共生菌和病原菌,对共生菌产生免疫耐受,而对病原菌及其他抗原物质产生免疫反应。Th17细胞是能产生IL-17的CD4+T淋巴细胞亚群,Th17的产生依赖于肠道共生菌的存在,并成为肠道免疫屏障的重要组成部分。它的适量存在有助于维持肠道免疫功能,而Th17的过度诱导则会导致肠道免疫功能破坏。此外,在肠道免疫系统中对共生菌耐受的CD4+CD25+Treg细胞及其产生的一致性细胞因子IL-10和TGF-β也发挥着重要作用,Th17细胞的分化发育又与Treg细胞分化发育呈抑制性关系。因此,Th17和Treg细胞是连接着肠道菌群和肠道免疫功能的关键细胞亚群。
产品信息
产品名称
|
产品编号
|
克隆号
|
应用
|
Anti-Mouse AHR Alexa Fluor® 488
|
53-5925
|
4MEJJ
|
FC
|
Anti-Mouse AHR eFluor® 660
|
50-5925
|
4MEJJ
|
FC
|
Anti-Mouse AHR PE
|
12-5925
|
4MEJJ
|
FC
|
Anti-Human AHR eFluor® 660
|
50-9854
|
FF3399
|
FC
|
Anti-Human AHR PE
|
12-9854
|
FF3399
|
FC
|
Anti-Human AHR PerCP-eFluor® 710
|
46-9854
|
FF3399
|
FC
|
Anti-Human AHR Purified
|
14-9854
|
FF3399
|
FC, ICC, IHC, WB
|
Anti-Mouse Aiolos eFluor® 660
|
50-5789
|
8B2
|
FC
|
Anti-Mouse Aiolos PE
|
12-5789
|
8B2
|
FC
|
Anti-Mouse Aiolos Purified
|
14-5789
|
8B2
|
WB
|
Anti-Human Foxp3 PE-Cyanine7
|
25-4776
|
PCH101
|
FC
|
Anti-Human/Mouse c-Maf eFluor® 660
|
50-9855
|
sym0F1
|
FC
|
Anti-Human/Mouse c-Maf PerCP-eFluor® 710
|
46-9855
|
sym0F1
|
FC
|
Anti-Human CCL5 (RANTES) eFluor® 660
|
50-9905
|
VL1
|
FC
|
Anti-Mouse CD4 Alexa Fluor® 488
|
53-0041
|
GK1.5
|
FC
|
Anti-Mouse CD4 APC
|
17-0041
|
GK1.5
|
FC
|
Anti-Mouse CD4 APC-eFluor® 780
|
47-0041
|
GK1.5
|
FC
|
Anti-Mouse CD4 Biotin
|
13-0041
|
GK1.5
|
FC
|
Anti-Mouse CD4 Cyanine5
|
19-0041
|
GK1.5
|
FC
|
Anti-Mouse CD4 eFluor® 450
|
48-0041
|
GK1.5
|
FC
|
Anti-Mouse CD4 eFluor® 605NC
|
93-0041
|
GK1.5
|
FC
|
Anti-Mouse CD4 eFluor® 650NC
|
95-0041
|
GK1.5
|
FC
|
Anti-Mouse CD4 eFluor® 660
|
50-0041
|
GK1.5
|
FC
|
Anti-Mouse CD4 FITC
|
11-0041
|
GK1.5
|
FC
|
Anti-Mouse CD4 Functional Grade Purified
|
16-0041
|
GK1.5
|
FC, FA
|
Anti-Mouse CD4 PE
|
12-0041
|
GK1.5
|
FC
|
Anti-Mouse CD4 PE-Cyanine5
|
15-0041
|
GK1.5
|
FC
|
Anti-Mouse CD4 PE-Cyanine7
|
25-0041
|
GK1.5
|
FC
|
Anti-Mouse CD4 PerCP-eFluor® 710
|
46-0041
|
GK1.5
|
FC
|
Anti-Mouse CD4 Purified
|
14-0041
|
GK1.5
|
FC, IHC, IP
|
Anti-Human CD4 Alexa Fluor® 488
|
53-0048
|
OKT4 (OKT-4)
|
FC
|
Anti-Human CD4 APC
|
17-0048
|
OKT4 (OKT-4)
|
FC
|
Anti-Human CD4 APC-eFluor® 780
|
47-0048
|
OKT4 (OKT-4)
|
FC
|
Anti-Human CD4 Biotin
|
13-0048
|
OKT4 (OKT-4)
|
FC
|
Anti-Human CD4 eFluor® 450
|
48-0048
|
OKT4 (OKT-4)
|
FC
|
Anti-Human CD4 eFluor® 605NC
|
93-0048
|
OKT4 (OKT-4)
|
FC
|
Anti-Human CD4 eFluor® 660
|
50-0048
|
OKT4 (OKT-4)
|
FC
|
Anti-Human CD4 FITC
|
11-0048
|
OKT4 (OKT-4)
|
FC
|
Anti-Human CD4 Functional Grade Purified
|
16-0048
|
OKT4 (OKT-4)
|
FC, IP
|
Anti-Human CD4 PE
|
12-0048
|
OKT4 (OKT-4)
|
FC
|
Anti-Human CD4 PerCP-Cyanine5.5
|
45-0048
|
OKT4 (OKT-4)
|
FC
|
Anti-Human CD4 Purified
|
14-0048
|
OKT4 (OKT-4)
|
FC, IP
|
Anti-Rat CD4 APC
|
17-0040
|
OX35
|
FC
|
Anti-Rat CD4 FITC
|
11-0040
|
OX35
|
FC
|
Anti-Rat CD4 PE
|
12-0040
|
OX35
|
FC
|
Anti-Rat CD4 PerCP-eFluor® 710
|
46-0040
|
OX35
|
FC
|
Anti-Rat CD4 Purified
|
14-0040
|
OX35
|
FC, IHC
|
Anti-Mouse CD4 Biotin
|
13-0043
|
RM4-4
|
FC
|
Anti-Mouse CD4 FITC
|
11-0043
|
RM4-4
|
FC
|
Anti-Human CD25 Alexa Fluor® 488
|
53-0259
|
BC96
|
FC
|
Anti-Human CD25 APC
|
17-0259
|
BC96
|
FC
|
Anti-Human CD25 APC-eFluor® 780
|
47-0259
|
BC96
|
FC
|
Anti-Human CD25 Biotin
|
13-0259
|
BC96
|
FC
|
Anti-Human CD25 eFluor® 450
|
48-0259
|
BC96
|
FC
|
Anti-Human CD25 PE
|
12-0259
|
BC96
|
FC
|
Anti-Human CD25 PE-Cyanine5
|
15-0259
|
BC96
|
FC
|
Anti-Human CD25 PE-Cyanine7
|
25-0259
|
BC96
|
FC
|
Anti-Human CD25 PerCP-Cyanine5.5
|
45-0259
|
BC96
|
FC
|
Anti-Human CD25 Purified
|
14-0259
|
BC96
|
FC
|
Anti-Human/Non-Human Primate CD25 APC
|
17-0257
|
CD25-4E3
|
FC
|
Anti-Human/Non-Human Primate CD25 eFluor® 450
|
48-0257
|
CD25-4E3
|
FC
|
Anti-Human/Non-Human Primate CD25 PE
|
12-0257
|
CD25-4E3
|
FC
|
Anti-Human/Non-Human Primate CD25 PE-Cyanine7
|
25-0257
|
CD25-4E3
|
FC
|
Anti-Human/Non-Human Primate CD25 PE-eFluor® 610
|
61-0257
|
CD25-4E3
|
FC
|
Anti-Human/Non-Human Primate CD25 PerCP-eFluor® 710
|
46-0257
|
CD25-4E3
|
FC
|
Anti-Mouse CD25 Alexa Fluor® 488
|
53-0253
|
eBio3C7 (3C7)
|
FC
|
Anti-Mouse CD25 eFluor® 450
|
48-0253
|
eBio3C7 (3C7)
|
FC
|
Anti-Mouse CD25 Functional Grade Purified
|
16-0253
|
eBio3C7 (3C7)
|
FC, FA
|
Anti-Mouse CD25 Alexa Fluor® 488
|
53-0252
|
eBio7D4 (7D4)
|
FC
|
Anti-Mouse CD25 Biotin
|
13-0252
|
eBio7D4 (7D4)
|
FC
|
Anti-Mouse CD25 eFluor® 660
|
50-0252
|
eBio7D4 (7D4)
|
FC
|
Anti-Rat CD25 APC
|
17-0390
|
OX39
|
FC, IHC
|
Anti-Rat CD25 Biotin
|
13-0390
|
OX39
|
FC, IHC
|
Anti-Rat CD25 Functional Grade Purified
|
16-0390
|
OX39
|
FC, FA
|
Anti-Rat CD25 PE
|
12-0390
|
OX39
|
FC
|
Anti-Rat CD25 PerCP-eFluor® 710
|
46-0390
|
OX39
|
FC
|
Anti-Rat CD25 Purified
|
14-0390
|
OX39
|
FC, IHC
|
Anti-Canine CD25 eFluor® 660
|
50-0250
|
P4A10
|
FC
|
Anti-Canine CD25 FITC
|
11-0250
|
P4A10
|
FC
|
Anti-Canine CD25 PE
|
12-0250
|
P4A10
|
FC
|
Anti-Mouse CD25 Alexa Fluor® 488
|
53-0251
|
PC61.5
|
FC
|
Anti-Mouse CD25 PE-Cyanine5.5
|
35-0251
|
PC61.5
|
FC
|
Anti-Mouse CD25 Alexa Fluor® 700
|
56-0251
|
PC61.5
|
FC
|
Anti-Mouse CD25 APC
|
17-0251
|
PC61.5
|
FC
|
Anti-Mouse CD25 APC-eFluor® 780
|
47-0251
|
PC61.5
|
FC
|
Anti-Helios eFluor® 450
|
48-9883
|
22F6
|
FC
|
Anti-Mouse Dectin-1 PE
|
12-5859
|
bg1fpj
|
FC
|
Anti-Mouse ST2 (IL-33R) PerCP-eFluor® 710
|
46-9335
|
RMST2-2
|
FC
|
Anti-Human CD294 (CRTH2) eFluor® 660
|
50-2949
|
BM16
|
FC
|
Anti-Human AHR eFluor® 660
|
50-9854
|
FF3399
|
FC
|
Human IL-23 Recombinant Protein Carrier-Free
|
34-8239
|
FA
|
|
Anti-Human IL-17AF eFluor® 450
|
48-9179
|
20LJS09
|
FC
|
参考文献
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