中心体扩增与肿瘤

中心体扩增与肿瘤
A causal relationship between centrosome defects (either structural or functional) and cancer development, progression, and aggressive clinical behavior has long been suspected, yet the underlying mechanism(s) have remained enigmatic. However, a recent publication in Nature by Godinho et. al.1 offers an explanation for the link between centrosome amplification and cancers. This group demonstrated that centrosome amplification leads to enhanced Rac1 activity, resulting in compromised cell-cell adhesion and increased invasiveness. This study represents an important step forward in the expanding field of centrosome biology associated with human malignancies.
Shown below is a compilation of the numbers of centrosome-related cancer research publications for various types of cancer2, highlighting the growing interest in this field.
Publication trends of centrosome-related cancer research
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gamma Tubulin antibody (GTX113286) GCP4 antibody (GTX115949) HICE1 antibody (GTX100735)
HAUS6 antibody (GTX118732) HAUS1 (CCDC5) antibody [N1C3] (GTX118733) alpha Tubulin antibody [GT114] (GTX628802)
Representative Publications
Product Name Citation GCP4 antibody (GTX115949) Nat Cell Biol doi: 10.1038/ncb2996. (2014). HICE1 antibody (GTX100735) PNAS 108 (28):11446-51 (2011). HAUS6 antibody (GTX118732) J Biol Chem 286 (34):30097-106 (2011). HAUS1 antibody [N1C3] (GTX118733) J Biol Chem 286 (34):30097-106 (2011). alpha Tubulin antibody [GT114] (GTX628802) J Virol 88 (5):2530-43 (2014).
1. Nature. 2014 Jun 5;510(7503):167-71.
2. Int J Biol Sci. 2011;7(8):1122-44.