半胱氨酰白三烯对脑的致损伤作用
目前认为 , 各种脑损伤 ( 脑缺氧、脑外伤 ) 的继发性损伤或称二次脑损伤 (secondary injury) 因素是造成脑损害发生、发展的重要原因。
这些因素涉及：脑缺氧、钙离子超载、氧自由基堆积、炎性因子的刺激等。其中炎症应答 (inflammatory response) 是脑损伤病理生理过程中的一个重要组成环节，半胱氨酰白三烯 (cysteinyl LTs) 包括LTC4, LTD4 和 LTE4 是一类重要的炎症反应介质 , 是花生四烯酸 5-脂氧合酶 (5-lipoxygenase,5-LOX) 的代谢产物。 CysLTs 通过激活半胱氨酰白三烯受体 ( 包括 CysLT1 和 CysLT2 受体 ), 参与多种炎症病理过程 , 介导平滑肌痉挛 (smooth muscle constriction) 、微血管渗漏 (vascular leak) 等。近年研究证明 , CysLTs 除在哮喘、过敏性鼻炎等炎症性疾病发病过程中起重要作用外 , 也参与脑卒中、脑外伤、脑肿瘤、癫痫等中枢神经系统疾病的病理生理过程。脑缺血后CysLTs 释放增加 , 5-LOX 抑制剂能减少 CysLTs 的产生，从而保护脑缺血性损伤。
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更多产品详情，请联系Cayman代理商-上海金畔生物