细胞因子报告基因细胞/趋势因子测试细胞
细胞因子与免疫系统细胞相互作用可调节宿主对于疾病和感染的反应，并介导正常的细胞过程。InvivoGen提供针对不同细胞因子（干扰素、白细胞介素、TNF和TGF）信号通路的报告基因细胞。所有细胞系的生物活性均经过严格的功能测试分析。另外，InvivoGen也提供一系列细胞因子报告基因细胞，可用于研究在更多严重感染病例中，如SARS-CoV-2引发的高度炎症反应的通路。
| 细胞系 | 产品名称 | 表达系统 | 报告系统 | 货号 |
| INTERFERONREPORTERCELLS | ||||
| B16(mouse) | B16-Blue™IFN-α/β | MousetypeIIFNs(JAK/ISGF3pathway) | SEAP | bb-ifnt1 |
| B16-Blue™IFN-γ | MousetypeIIIFN(JAK/STAT-1pathway) | SEAP | bb-ifng | |
| HEK293(human) | HEK-Blue™IFN-α/β | HumantypeIIFNs(JAK/ISGF3pathway) | SEAP | hkb-ifnab |
| HEK-Blue™IFN-γ | HumantypeIIIFN(JAK/STAT-1pathway) | SEAP | hkb-ifng | |
| HEK-Blue™IFN-λ | HumantypeIIIIFN(JAK/ISGF3pathway) | SEAP | hkb-ifnl | |
| HEK-Dual™IFN-γ | HumantypeIIIFN(JAK/STAT-1pathway) | SEAP/Lucia | hkd-ifng | |
| INTERLEUKINREPORTERCELLS | ||||
| HEK293 (human) | HEK-Blue™IL-1β | Human&mouseIL-1β(NF-κB/AP-1pathway) | SEAP | hkb-il1b |
| HEK-Blue™IL-1R | Human&mouseIL-1α/β(NF-κB/AP-1pathway) | SEAP | hkb-il1r | |
| HEK-Blue™IL-2 | Human&mouseIL-2(STAT-5pathway) | SEAP | hkb-il2 | |
| HEK-Blue™CD122/CD132 | HumanIL-2&IL-15(STAT-5pathway) | SEAP | hkb-il2bg | |
| HEK-Blue™IL-4/IL-13 | HumanIL-4andhuman&mouseIL-13(STAT-6pathway) | SEAP | hkb-il413 | |
| HEK-Blue™IL-5 | Human&mouseIL-5(STAT-5pathway) | SEAP | hkb-il5 | |
| HEK-Blue™IL-6 | HumanIL-6(STAT-3pathway) | SEAP | hkb-hil6 | |
| HEK-Blue™IL-7 | Human&mouseIL-7(STAT-5pathway) | SEAP | hkb-il7 | |
| HEK-Blue™IL-9 | Human&mouseIL-9(STAT-5pathway) | SEAP | hkb-il9 | |
| HEK-Blue™IL-10 | HumanIL-10(STAT-3pathway) | SEAP | hkb-hil10 | |
| HEK-Blue™IL-11 | Human&mouseIL-11(STAT-3pathway) | SEAP | hkb-il11 | |
| HEK-Blue™IL-12 | Human&mouseIL-12(STAT-4pathway) | SEAP | hkb-il12 | |
| HEK-Blue™IL-17 | HumanIL-17A/Fandhuman&mouseIL-17E(NF-κB/AP-1pathway) | SEAP | hkb-il17 | |
| HEK-Blue™IL-17C | Human&mouseIL-17C/EandhumanIL-17A(NF-κB/AP-1pathway) | SEAP | hkb-il17c | |
| HEK-Blue™IL-18 | Human&mouseIL-18(NF-κB/AP-1pathway) | SEAP | hkb-hmil18 | |
| HEK-Blue™IL-22 | Human&mouseIL-22(STAT-3pathway) | SEAP | hkb-hmil22 | |
| HEK-Blue™IL-23 | Human&mouseIL-23(STAT-3pathway) | SEAP | hkb-hmil23 | |
| HEK-Blue™IL-33 | HumanIL-33reportercells(NF-κB/AP-1pathway) | SEAP | hkb-hil33 | |
| HEK-Blue™IL-36 | HumanIL-36reportercells(NF-κB/AP-1pathway) | SEAP | hkb-hil36 | |
| TUMORNECROSISFACTORFAMILYCYTOKINES&TUMORGROWTHFACTORREPORTERCELLS | ||||
| HEK293 (human) | HEK-Blue™CD40L | HumanCD40L(NF-κBpathway) | SEAP | hkb-cd40 |
| HEK-Blue™RANKL | Human&mouseRANKL(NF-κB/AP-1pathway) | SEAP | hkb-rankl | |
| HEK-Blue™TNF-α | Human&mouseTNF-α(NF-κB/AP-1pathway),knockdownofhumanMyD88 | SEAP | hkb-tnfdmyd | |
| HEK-Dual™TNF-α | Human&mouseTNF-α(NF-κB/AP-1pathway),knockdownofhumanMyD88 | SEAP/Lucia | hkd-tnfa | |
| HEK-Blue™TGF-β | HumanTGF-β(TGFBRI/Smad3/4pathway) | SEAP | hkb-tgfb | |
| HEK-Blue™TPO | Human&mouseTPO(STAT5pathway) | |||
| CHEMOKINETESTCELLS | ||||
| THP-1(human) | THP1-Blue™KI-IP10 | LuciaknockedintohumanIP10(CXCL10)(parentalcelllineTHP1-Blue™NF-κB) | SEAP/Lucia | thpb-ip10kilc |
使用INVIVOGEN细胞因子效应器细胞的优点
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细胞因子生物活性的检测
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高灵敏度
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成本效益
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广泛的动态范围
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短暂动手实验
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裸眼视觉化
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适用于药物筛选（普通筛选或高通量筛选，动力学）
详情请联系 Invivogen 全国代理-上海金畔生物科技