HS-276 is a highly selective, orally active inhibitor of TAK1 (Ki: 2.5 nM). HS-276 significantly inhibits TAK1 (IC50: 8.25 nM), CLK2 (IC50: 29 nM), GCK (IC50: 22 nM), ULK2 (IC50: 63 nM), MAP4K5 (IC50. HS-276 can be used to study rheumatoid arthritis (RA).

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

DMSO:45.0 mg/mL (107.3 mM)

IRAK1:264 nM, CSNK1G2:810 nM, CAMKKβ-1:1280 nM, CLK2:29 nM, MLK1:5585 nM, ULK2:63 nM, TAK1:8.25 nM, TAK1:2.5 nM (Ki), MAP4K5:125 nM, NUAK:270 nM, GCK:33 nM