LY-402913CAS号： 334970-65-9分子式： C28H24ClN3O6分子量： 533.96描述纯度储存/保存方法可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
LY-402913 is a selective multidrug resistance protein (MRP1) inhibitor.
|
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 可溶性/溶解性 |
DMSO:50 mg/mL (93.64 mM)
|
| 生物活性 | |
| In vitro(体外研究) |
LY-402913 inhibits MRP1 and reverses drug resistance to MRP1 substrates, such as doxorubicin, in HeLa-T5 cells (EC50=0.90 μM), while showing no inherent cytotoxicity. LY-402913 inhibits ATP-dependent, MRP1-mediated LTC4 uptake into membrane vesicles prepared from the MRP1-overexpressing HeLa-T5 cells (EC50=1.8 μM). LY-402913 also shows selectivity (∼22-fold) against the related transporter, P-glycoprotein, in HL60/Adr and HL60/Vinc cells[2].
|
| In vivo(体内研究) |
When dosed in combination with the oncolytic MRP1 substrate vincristine, LY-402913 delays the growth of MRP1-overexpressing tumors in vivo[2].
|