4-Hydroxyphenylacetic acidCAS号： 156-38-7分子式： C8H8O3分子量： 152.15描述纯度储存/保存方法形态别名外观可溶性/溶解性靶点In vivo(体内研究)
| 产品描述 | |
| 描述 |
4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2. |
| 纯度 |
≥98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 形态 |
Solid
|
| 基本信息 | |
| 别名 |
对羟基苯乙酸；4-羟基苯乙酸；p-hydroxyphenylacetic acid
|
| 外观 |
White to cream or light tan Crystalline Powder
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| 可溶性/溶解性 |
DMSO : 28 mg/mL (184 mM)
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| 生物活性 | |
| 靶点 |
Nrf2
|
| In vivo(体内研究) |
4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1.
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分子结构图
