Arbidol Hydrochloride；盐酸阿比朵尔
货号：
IA2190
品牌：
Jinpan
暂无详情
产品简介
| MDL | MFCD00344795 |
| EC | EINECS 680-680-9 |
| 别名 | Umifenovirhydrochloride,ArbidolHCl |
| 英文名称 | Arbidol Hydrochloride |
| CAS | 131707-23-8 |
| 分子式 | C22H25BrN2O3S·HCl |
| 分子量 | 513.88 |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| 生物活性 | Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells[1][2].Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity[3]. |
| In Vitro | Umifenovir hydrochloride exhibits a wide range and potent antiviral activity against a number of viruses including influenza A, B and C viruses, respiratory syncytial virus, adenovirus, parainfluenza type 5 and rhinovirus type 14, avian coronavirus, infectious bronchitis virus and Marek disease virus, hepatitis B virus and hepatitis C virus[1]. |
| In Vivo | Umifenovir (45-180 mg/kg; p.o.; daily for 5 days) suppresses the transcription of influenza viruses (IFV) -associated inflammatory cytokines[2]. |
| SMILES | Cl.CCOC(=O)C1=C(CSC2=CC=CC=C2)N(C)C2=C1C(CN(C)C)=C(O)C(Br)=C2 |
| 靶点 | Influenza Virus |
| 数据来源文献 | [1]. Boriskin YS, et al. Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr Med Chem. 2008;15(10):997-1005. [2]. Liu Q, et al. Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection. Acta Pharmacol Sin. 2013;34(8):1075-1083. [3]. Wang X, et al. The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 2020;6:28. Published 2020 May 2. |
| 规格 | 50mg 100mg 500mg |
是广谱的抗病毒化合物，能通过阻断病毒与宿主细胞的融合抑制包装病毒进入细胞。