Beclomethasone Dipropionate；丙酸倍氯米松
货号：
IB2150
品牌：
Jinpan
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产品简介
| EC | EINECS 226-886-0 |
| InChIKey | KUVIULQEHSCUHY-XYWKZLDCSA-N |
| InChI | InChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1 |
| PubChem CID | 21700 |
| 别名 | 倍氯米松双丙酸酯; 氯地米松; 二丙酸培氯松 |
| CAS | 5534-09-8 |
| 分子式 | C28H37ClO7 |
| 分子量 | 521.04 |
| 储存条件 | 2-8℃ |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| 生物活性 | Betamethasone dipropionate, the prodrug of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release[1-2]. |
| In Vitro | The Calcipotriol/Betamethasone combination significantly inhibits the secretion of IL-17A and TNF-α in psoriatic skin. Additionally, the two components show additive inhibitory effects on secretion of IL-23 and TNF-α by DCs, of IL-17A and TNF-α by both CD4+ and CD8+ T cells and reduced inflammatory responses in Th17-stimulated keratinocytes[1]. |
| In Vivo | Betamethasone (5 mg/kg, orally) reduces the LPS-induced pulmonary inflammation and production of MMPs. Significantly (P < 0.05) inhibited the decrease of IL-10 level in BAL fluid induced by LPS exposure.Markedly reduced the release of both MMP-2 and MMP-9.[2]. |
| SMILES | CCC(O[C@]1(C(COC(CC)=O)=O)[C@@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)C3(Cl)[C@@H](O)C[C@]12C)=O)=O |
| 靶点 | Glucocorticoid Receptor |
| 细胞实验 | Animal Model: Ten-week-old male Balb/c mice; Dosage: 5 mg/kg (100 μg/ml for 60 min).; Administration: Orally at 24 h and 1 h before the LPS aerosol.[2] |
| 数据来源文献 | [1]. Paola Lovato, et al. Calcipotriol and betamethasone dipropionate exert additive inhibitory effects on the cytokine expression of inflammatory dendritic cell-Th17 cell axis in psoriasis. J Dermatol Sci. 2016 Mar;81(3):153-64. [2]. M Corbel, et al. Comparative effects of betamethasone, cyclosporin and nedocromil sodium in acute pulmonary inflammation and metalloproteinase activities in bronchoalveolar lavage fluid from mice exposed to lipopolysaccharide. Pulm Pharmacol Ther. 1999;12(3):165-71. |
| 规格 | 250mg |
Beclomethasone dipropionate是一种强有效的糖皮质激素