BI-78D3
货号：
IB2400
品牌：
Jinpan
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产品简介
| 有效期 | 2年 |
| MDL | MFCD01313575 |
| 英文名称 | BI-78D3 |
| CAS | 883065-90-5 |
| 分子式 | C13H9N5O5S2 |
| 分子量 | 379.37 |
| 储存条件 | 2-8℃ |
| 纯度 | ≥98% |
| 外观（性状） | Solid |
| 单位 | 瓶 |
| 生物活性 | BI-78D3是一种竞争性的JNK抑制剂，IC50为280 nM，其选择性比对p38α高100倍，对mTOR和PI-3K没有活性。[1] |
| IC50 | JNK: 280 nM [1] |
| In Vitro | BI-78D3 在体外和细胞中剂量依赖性地抑制 JNK 底物的磷酸化。[1] |
| In Vivo | 在动物研究中，BI-78D3 不仅能阻断 JNK 依赖的 Con A 诱导的肝损伤，还能恢复 2 型糖尿病小鼠模型的胰岛素敏感性[1]。 |
| SMILES | O=C1N(C2=CC=C(OCCO3)C3=C2)C(SC4=NC=C([N+]([O-])=O)S4)=NN1 |
| 靶点 | JNK |
| 动物实验 | Liver Injury Model. ConA and BI-78D3 was injected i.v. at 10 mg/kg into 6 to 8 weeks old male BL/6 mice. For partial hepatectomy, mice were anesthetized with isofluorane and subjected to midventral laparotomy followed by removal of the left lateral and median lobes. Animals were killed, blood was collected by cardiac puncture, and livers were surgically removed. Serum was separated and analyzed for alanine-aminotranferase levels.[1] |
| 数据来源文献 | [1] Stebbins JL, et al. Proc Natl Acad Sci U S A. 2008, 105(43):16809-16813. |
| 规格 | 5mg 10mg |
是一种新颖，有效且具有竞争力的JNK抑制剂