对氨基马尿酸
货号：
IA2720
品牌：
Jinpan
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产品简介
| EC | EINECS 200-518-9 |
| MDL | MFCD00007890 |
| 描述 | 是一种诊断剂, 用于肾脏检测, 在肾血浆流量的测定中使用。 |
| InChIKey | HSMNQINEKMPTIC-UHFFFAOYSA-N |
| InChI | InChI=1S/C9H10N2O3/c10-7-3-1-6(2-4-7)9(14)11-5-8(12)13/h1-4H,5,10H2,(H,11,14)(H,12,13) |
| PubChem CID | 2148 |
| 别名 | 4-氨基马尿酸；p-Aminohippuric acid |
| 英文名称 | 4-Aminohippuric Acid |
| CAS | 61-78-9 |
| 分子式 | C9H10N2O3 |
| 分子量 | 194.19 |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| 生物活性 | p-aminohippuric acid (PAH) is a typical substrate of organic anion transport systems.[1] |
| In Vitro | Organic anions are secreted into urine via organic anion transporters across the renal basolateral and apical membranes. human NPT1, which is present in renal apical membrane, mediates the transport of PAH. The K(m) value for PAH uptake was 2.66 mM and the uptake was chloride ion sensitive. PAH transport was inhibited by various anionic compounds.[1] |
| SMILES | O=C(O)CNC(C1=CC=C(N)C=C1)=O |
| 靶点 | Others |
| 动物实验 | For efflux experiments, transfected HEK293 cells were washed in the standard reaction buffer (125 mM Na gluconate, 4.8 mM K gluconate, 5.6 mM D-glucose, 1.2 mM Ca gluconate, 1.2 mM Mg gluconate and 25 mM Hepes (pH 7.4), resuspended in the transport buffer containing 100 m M [3H]PAH (2 m Ci) and incubated for 10 min. The cells were then pelleted by centrifugation at 10,000 rpm for 10 s and efflux was initiated by resuspending the cells in the transport buffer. The reaction was terminated by separating the cells from the medium by a centrifugal filtration technique as described previously[1]. |
| 数据来源文献 | [1]. Uchino H, Tamai I, Yamashita K, Minemoto Y, Sai Y, Yabuuchi H, Miyamoto Ki, Takeda E, Tsuji A. p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1. Biochem Biophys Res Commun. 2000 Apr 2;270(1):254-9. |
| 规格 | 25mg 50mg 100mg 500mg |
是一种诊断剂, 用于肾脏检测, 在肾血浆流量的测定中使用。