BioXCell热销产品—InVivoMAb anti-human CD3(货号:BE0231)

BioXCell热销产品—InVivoMAb anti-human CD3(货号:BE0231)

克隆号UCHT1 (Leu-4)(T3)单克隆抗体与人CD3ε一种属于免疫球蛋白超家族的20 kDa跨膜细胞表面蛋白反应。CD3ε是结合形成TCR复合物的五个多肽链之一。CD3ε在T淋巴细胞NK-T细胞上表达,并在不同程度上在发育中的胸腺细胞上表达。CD3TCR信号T淋巴细胞活化和抗原识别中发挥作用。通过固定化UCHT1 (Leu-4)(T3)抗体交联TCR通常用于体外激活T细胞。

(InVivoMAb anti-human CD3产品图片)


产品详情

产品货号

BE0231

产品规格

1/5/25/50/100mg

抗体亚型

Mouse IgG1, κ

推荐同型对照

InVivoMAb mouse IgG1 isotype control, unknown specificity(货号:BE0083

推荐抗体稀释液

InVivoPure pH7.0 Dilution Buffer(货号:IP0065

免疫原

Human CD3ε

应用

in vivo T cell depletion in humanized mice

ex vivo T cell inhibition for xenographs

Flow cytometry

产品形式

PBS , pH 7.0

Contains no stabilizers or preservatives

内毒素水平

<2eu>μ

g)

使用 LAL gel clotting 测定

纯度

>95% Determined by SDS-PAGE

无菌处理

0.2 μM filtered

生产形式

从组织培养上清液中纯化得到。

纯化形式

Protein G

RRID

AB_2687713

分子量大小

150 kDa

保存条件

抗体原溶液应保存在4°C条件下,不要冷冻保存。

 

已发表参考文献:

in vivo T cell depletion in humanized mice

Wunderlich, M., et al. (2014). “OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues.” Blood 123(24): e134-144.

in vivo T cell depletionn

Woo, J. H., et al. (2010). “Pharmacology of anti-CD3 diphtheria immunotoxin in CD3 positive T-cell lymphoma trials.” Methods Mol Biol 651: 157-175.

Flow cytometry

Rossi, N. E., et al. (2008). “Differential antibody binding to the surface alphabetaTCR.CD3 complex of CD4+ and CD8+ T lymphocytes is conserved in mammals and associated with differential glycosylation.” Int Immunol 20(10): 1247-1258.

 

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