BioXCell热销产品—InVivoMAb anti-human CD3(货号:BE0231)
克隆号UCHT1 (Leu-4)(T3)单克隆抗体与人CD3ε一种属于免疫球蛋白超家族的20 kDa跨膜细胞表面蛋白反应。CD3ε是结合形成TCR复合物的五个多肽链之一。CD3ε在T淋巴细胞NK-T细胞上表达,并在不同程度上在发育中的胸腺细胞上表达。CD3在TCR信号T淋巴细胞活化和抗原识别中发挥作用。通过固定化UCHT1 (Leu-4)(T3)抗体交联TCR通常用于体外激活T细胞。
(InVivoMAb anti-human CD3产品图片)
产品详情
产品货号 |
BE0231 |
产品规格 |
1/5/25/50/100mg |
抗体亚型 |
Mouse IgG1, κ |
推荐同型对照 |
InVivoMAb mouse IgG1 isotype control, unknown specificity(货号:BE0083) |
推荐抗体稀释液 |
InVivoPure™ pH7.0 Dilution Buffer(货号:IP0065) |
免疫原 |
Human CD3ε |
应用 |
in vivo T cell depletion in humanized mice ex vivo T cell inhibition for xenographs Flow cytometry |
产品形式 |
PBS , pH 7.0 Contains no stabilizers or preservatives |
内毒素水平 |
<2eu>μ |
g)
使用 LAL gel clotting 测定
纯度
>95% Determined by SDS-PAGE
无菌处理
0.2 μM filtered
生产形式
从组织培养上清液中纯化得到。
纯化形式
Protein G
RRID
AB_2687713
分子量大小
150 kDa
保存条件
抗体原溶液应保存在4°C条件下,不要冷冻保存。
已发表参考文献:
in vivo T cell depletion in humanized mice |
Wunderlich, M., et al. (2014). “OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues.” Blood 123(24): e134-144. |
in vivo T cell depletionn |
Woo, J. H., et al. (2010). “Pharmacology of anti-CD3 diphtheria immunotoxin in CD3 positive T-cell lymphoma trials.” Methods Mol Biol 651: 157-175. |
Flow cytometry |
Rossi, N. E., et al. (2008). “Differential antibody binding to the surface alphabetaTCR.CD3 complex of CD4+ and CD8+ T lymphocytes is conserved in mammals and associated with differential glycosylation.” Int Immunol 20(10): 1247-1258. |
详情请咨询 BioXcell 中国代理–上海金畔生物