TL2-C29，TLR2信号抑制剂新品上线

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TL2-C29，TLR2信号抑制剂新品上线

法国InvivoGen最新推出人TLR2/1 & TLR2/6, 小鼠TLR2/1 信号抑制剂TL2-C29，为TLR2信号研究的科研人员提供最新工具。

 

TL2-C29 是一种Toll样受体2 (TLR2)的小分子抑制剂 [1]，TLR2在检测来自细菌、真菌、寄生虫和病毒的多种病原相关分子模式（PAMPs）中起着非常重要的作用 [2]。TLR1和TLR6的共受体(co-receptors)对TLR2 信号和配体的特异性有关键影响。细胞表面的TLR2/TLR1和TLR2/TLR6异二聚体可分别结合三酰化和二酰化脂蛋白 [3,4]。TLR2信号是由配体诱导的TLR2异二聚体和衔接蛋白（adapter proteins）的基本细胞质TIR（Toll/IL-1受体）结构域的二聚化启动。随后的信号级联导致促炎症反应。

 

TL2-C29抑制TLR2信号作用机理

TL2-C29，TLR2信号抑制剂新品上线 

 

产品信息

名称：TL2-C29

规格：5mg

货号：inh-c29

别名: C29; TLR2-IN-C29; 3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-benzoic acid

CAS号: 363600-92-4

分子式: C16H15NO4

分子量: 285.3 g/mol

溶解度: 50 mM (14.3 mg/ml) in DMSO

工作浓度: 25 – 200 µM for cell culture assays.

质控:

     · Purity ≥ 95% (NMR)

     · Inhibition of human TLR2/1 and TLR2/6 signaling has been confirmed using cellular assays

     · The absence of bacterial contamination (e.g. lipoproteins and endotoxins) has been confirmed using HEK-Blue™ TLR2 and HEKBlue™ TLR4 cells.

 

 

主要特点:

–人TLR2/1和TLR2/6信号的高效抑制剂

–小鼠TLR2/1信号的高效抑制剂

–无明显细胞毒性

–在细胞试验上验证可抑制NF-κB/AP-1信号

–每个批次纯度均大于≥ 95%，并经过功能性测试

 

InvivoGen实验室数据支持

TL2-C29，TLR2信号抑制剂新品上线 

 

TL2-C29，TLR2信号抑制剂新品上线

 

 

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产品名称

描述

Pam3CSK4 

TLR2/TLR1 Agonist – Synthetic triacylated lipopeptide

Pam2CSK4 

TLR2/TLR6 Agonist – Synthetic diacylated lipopeptide

FSL-1 

TLR2/TLR6 Agonist – Synthetic diacylated lipoprotein

HKLM 

TLR2 Agonist – Heat Killed Listeria monocytogenes

HKPA 

TLR2 Agonist – Heat Killed – Pseudomonas aeruginosa

HEK-Blue™ hTLR2 

Human TLR2 / NF-κB / SEAP reporter HEK293 cells

QUANTI-Blue™ 

Alkaline phosphatase detection medium

HEK-Blue™ hTLR2-TLR1 

Human TLR2+TLR1 / NF-κB / SEAP reporter HEK293 cells

HEK-Blue™ hTLR2-TLR6 

Human TLR2+TLR6 / NF-κB / SEAP reporter HEK293 cells

HEK-Blue™ hTLR2 KO-TLR1/6 

Human TLR2 (KO-TLR1/6) / NF-κB / SEAP reporter HEK293 cells

 

参考文献

1. Mistry, P. et al., 2015. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. PNAS. 112(17):5455-5460.
2. Oliveira-Nascimento L. et al., 2012. The role of TLR2 in infection and Immunity. Front Immunol. 3(79): doi:10.3389/fimmu.2012.00079.
3. Takeuchi O. et al., 2001. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol. 13: 933-940.
4. Takeuchi O. et al., 2002. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol. 169: 10-14

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